New pill could shrink uterine cancer without surgery

NCT ID NCT05634499

Ongoing Disease control Sponsor: Hoffmann-La Roche Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 10, 2026 · Updated 1 time

Summary

This phase II trial is testing an oral drug called giredestrant in 30 people with grade 1 endometrial cancer. The goal is to see if the drug can shrink or control the cancer over 6 months. Participants take one pill daily for up to 24 cycles, and doctors monitor tumor changes and side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: giredestrant (oral drug)
What this could lead to: If successful, this could offer a non-surgical, hormone-based option to control early-stage endometrial cancer.
What could go wrong: This is a small, early-phase trial with only 30 participants and no comparison group. The drug may not shrink tumors or could cause side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

endometrial cancer endometrial endometrioid adenocarcinoma endometrium neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ENDOMETRIAL CANCER

Contacts and locations

Locations

Englewood Health/Hematology Oncology Practice of Englewood (HOPE)

Englewood, New Jersey, 07631, United States
Istituto Scientifico Romagnolo Per Lo Studio E La Cura Dei Tumori IRST - PPDS

Meldola, Emilia-Romagna, 47014, Italy
Jewish General Hospital

Montreal, Quebec, H3T 1E2, Canada
McGill University Health Centre - Glen Site

Montreal, Quebec, H4A 3J1, Canada
Minnesota Oncology Minneapolis

Minneapolis, Minnesota, 55404, United States
Mount Sinai Medical Center

Miami Beach, Florida, 33140, United States
Narodowy Inst.Onkol.im.Sklodowskiej-Curie Panstw.Inst.Bad Gliwice

Gliwice, 44-101, Poland
Swietokrzyskie Centrum Onkologii

Kielce, 25-734, Poland
Texas Oncology, P.A. - Fort Worth

Fort Worth, Texas, 76104, United States
University of Arkansas for Medical Sciences

Little Rock, Arkansas, 72205, United States
Virginia Oncology Associates

Norfolk, Virginia, 23502, United States
Western Pennsylvania Hospital

Pittsburgh, Pennsylvania, 15224, United States

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