New combo aims to unleash immune system against tough ovarian cancer

NCT ID NCT05200559

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This study tests whether a two-drug combination can help the immune system attack ovarian cancer that has returned after standard treatments. The drugs are E7777, which removes certain immune cells that block the body's defenses, and pembrolizumab, which reactivates cancer-fighting immune cells. About 25 adults with advanced solid tumors, including ovarian cancer, will take part to find the safest dose and see if the tumors shrink.

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Conditions

The condition(s) this trial relates to.

Carcinoma, Ovarian Epithelial cutaneous melanoma endometrial cancer mismatch repair cancer syndrome 1 non-small cell lung carcinoma ovarian carcinoma renal cell carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • UPMC Hillman Cancer Center

    Pittsburgh, Pennsylvania, 15232, United States