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New drug shows promise against multiple Hard-to-Treat cancers

NCT ID NCT04482309

Ongoing Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a drug called trastuzumab deruxtecan (T-DXd) in people with various advanced cancers that have a protein called HER2. The goal is to see if the drug can shrink tumors and control the disease. About 477 participants with cancers like bladder, cervical, ovarian, and pancreatic cancer will receive the drug. The study is open-label, meaning everyone knows they are getting the treatment.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

biliary tract cancer cervical cancer colorectal neoplasm endometrial cancer malignant pancreatic neoplasm ovarian cancer pancreatic neoplasm urinary bladder carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PART 1: BLADDER, BILIARY TRACT, CERVICAL, ENDOMETRIAL, OVARIAN, PANCREATIC CANCER, RARE TUMORS, ANY TUMOR TYPE EXCLUDING BREAST, GASTRIC, COLORECTAL CANCER PART 2: HER2 EXPRESSING/AMPLIFIED SOLID TUMORS EXCLUDING BREAST, GASTRIC, COLORECTAL CANCER

Contacts and locations

Locations

  • Research Site

    Duarte, California, 91010, United States

  • Research Site

    Santa Rosa, California, 95403, United States

  • Research Site

    Chicago, Illinois, 60637, United States

  • Research Site

    Muncie, Indiana, 47303, United States

  • Research Site

    Boston, Massachusetts, 02215, United States

  • Research Site

    Middletown, New Jersey, 07748, United States

  • Research Site

    Harrison, New York, 10604, United States

  • Research Site

    New York, New York, 10029, United States

  • Research Site

    New York, New York, 10065, United States

  • Research Site

    Durham, North Carolina, 27710, United States

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    Houston, Texas, 77030, United States

  • Research Site

    Seattle, Washington, 98195, United States

  • Research Site

    Auchenflower, 4066, Australia

  • Research Site

    Blacktown, 2148, Australia

  • Research Site

    Camperdown, 2050, Australia

  • Research Site

    Heidelberg, 3084, Australia

  • Research Site

    Melbourne, 3000, Australia

  • Research Site

    Nedlands, 6009, Australia

  • Research Site

    Brussels, 1090, Belgium

  • Research Site

    Leuven, 3000, Belgium

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    Liège, 4000, Belgium

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    Porto Alegre, 90035-000, Brazil

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    São Paulo, 01246-000, Brazil

  • Research Site

    Vitória, 29043-272, Brazil

  • Research Site

    Kelowna, British Columbia, V1Y 5L3, Canada

  • Research Site

    Ottawa, Ontario, K1H 8L6, Canada

  • Research Site

    Québec, Quebec, G1J 1Z4, Canada

  • Research Site

    Montreal, H3T 1E2, Canada

  • Research Site

    Brno, 656 53, Czechia

  • Research Site

    Hradec Králové, 500 05, Czechia

  • Research Site

    Olomouc, 77900, Czechia

  • Research Site

    Prague, 150 06, Czechia

  • Research Site

    Prague, 180 81, Czechia

  • Research Site

    Delhi, 110085, India

  • Research Site

    Gurgaon, 122001, India

  • Research Site

    Kolkata, 700160, India

  • Research Site

    Mumbai, 400012, India

  • Research Site

    Milan, 20162, Italy

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    Milan, 20141, Italy

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    Naples, 80131, Italy

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    Rome, 168, Italy

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    Chūōku, 104-0045, Japan

  • Research Site

    Kashiwa, 277-8577, Japan

  • Research Site

    Suita-shi, 565-0871, Japan

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    Amsterdam, 1066CX, Netherlands

  • Research Site

    Delft, 2625 AD, Netherlands

  • Research Site

    Groningen, 9700, Netherlands

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    Bydgoszcz, 85-796, Poland

  • Research Site

    Gdansk, 80-952, Poland

  • Research Site

    Krakow, 31-501, Poland

  • Research Site

    Poznan, 60-355, Poland

  • Research Site

    Warsaw, 02-781, Poland

  • Research Site

    Kaluga, 248007, Russia

  • Research Site

    Moscow, 115419, Russia

  • Research Site

    Moscow, 115478, Russia

  • Research Site

    Moscow, 117997, Russia

  • Research Site

    Moscow, 121205, Russia

  • Research Site

    Moscow, 143423, Russia

  • Research Site

    Moscow, 143442, Russia

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    Saint Petersburg, 195271, Russia

  • Research Site

    Saint Petersburg, 197758, Russia

  • Research Site

    Seoul, 03080, South Korea

  • Research Site

    Seoul, 03722, South Korea

  • Research Site

    Seoul, 06351, South Korea

  • Research Site

    Seoul, 5505, South Korea

  • Research Site

    Barcelona, 8035, Spain

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    Córdoba, 14004, Spain

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    Madrid, 28027, Spain

  • Research Site

    Madrid, 28040, Spain

  • Research Site

    Madrid, 28041, Spain

  • Research Site

    Madrid, 28046, Spain

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    Valencia, 46014, Spain

  • Research Site

    Taichung, 40705, Taiwan

  • Research Site

    Tainan, 736, Taiwan

  • Research Site

    Taipei, 100, Taiwan

  • Research Site

    Taipei, 10449, Taiwan

  • Research Site

    Taipei, 11217, Taiwan

  • Research Site

    Taoyuan, 333, Taiwan

  • Research Site

    Bangkok, 10210, Thailand

  • Research Site

    Bangkok, 10330, Thailand

  • Research Site

    Bangkok, 10400, Thailand

  • Research Site

    Chiang Mai, 50200, Thailand

  • Research Site

    Hat Yai, 90110, Thailand

  • Research Site

    Khon Kaen, 40002, Thailand

  • Research Site

    Muang, 50200, Thailand

  • Research Site

    Ongkharak, 26120, Thailand

  • Research Site

    London, SW2 6JJ, United Kingdom

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    Manchester, M20 4BX, United Kingdom

  • Research Site

    Sutton, SM2 5PT, United Kingdom