New drug targets Hard-to-Treat cancers in early trial

NCT ID NCT07260513

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This early-phase study tests a new drug called GH2616 in about 126 people with advanced solid tumors that have not responded to other treatments. The drug works by blocking a protein (KIF18A) that helps cancer cells divide, which may slow or stop tumor growth. The main goals are to check safety, find the best dose, and see if the drug can shrink tumors.

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Conditions

The condition(s) this trial relates to.

cancer endometrial cancer ovarian serous adenocarcinoma triple-negative breast carcinoma uterine carcinosarcoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Fudan University Shanghai Cancer Center

    Shanghai, Shanghai Municipality, China

  • Peking Union Medical College Hospital

    Beijing, Beijing Municipality, China