New drug targets Hard-to-Treat cancers in major trial

NCT ID NCT06660654

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new drug called raludotatug deruxtecan (R-DXd) in 200 adults with advanced or spreading solid tumors, including certain ovarian, cervical, endometrial, bladder, and kidney cancers. The goal is to see if the drug can shrink tumors or stop them from growing. Participants must have tumors that have gotten worse after prior treatment. This is not a cure, but aims to control the disease.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

cervical cancer endometrial cancer metastatic malignant neoplasm nonpapillary renal cell carcinoma urothelial carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • AO per lEmergenza Cannizzaro

    Catania, 95126, Italy

  • Aichi Cancer Centre

    Nagoya, 464-8681, Japan

  • Asan Medical Center

    Seoul, 05505, South Korea

  • Astera Cancer Care

    East Brunswick, New Jersey, 08816, United States

  • Azienda Ospedaliera S Maria

    Terni, 05100, Italy

  • Cario - Centre Armoricain de Radiothérapie, Imagerie Médicale Et Oncologie

    Plérin, 22190, France

  • Centre Georges-François Leclerc

    Dijon, 21079, France

  • Centre Leon Berard

    Lyon, 69008, France

  • Centre Oscar Lambret

    Lille, 59 000, France

  • Clinical Research Alliance

    Westbury, New York, 11590, United States

  • Federico II Hospital

    Naples, 80131, Italy

  • Fondazione IRCCS Istituto Nazionale dei Tumori

    Milan, 40121, Italy

  • François Baclesse Center

    Caen, 14000, France

  • Grp Hsp Diac Croix Saint Simon

    Paris, 75012, France

  • Gustave Roussy

    Villejuif, 94800, France

  • Herlev og Gentofte Hosp

    Copenhagen, 2100, Denmark

  • Hospital 12 Octubre

    Madrid, 28041, Spain

  • Hospital Universitario Virgen de la Victoria

    Málaga, 29010, Spain

  • Hospital Universitario de A Coruña

    A Coruña, 15006, Spain

  • Hospital de Sant Pau

    Barcelona, 08041, Spain

  • Hunan Cancer Hospital

    Changsha, 410013, China

  • Hyogo Cancer Center

    Akashi, 13-70, Japan

  • IRCCS Dino Amadori - IRST

    Meldola, 47014, Italy

  • IRCCS San Raffaele

    Milan, 20132, Italy

  • Ico - Site René Gauducheau

    Saint-Herblain, 44805, France

  • Institut Claudius Regaud

    Toulouse, 31100, France

  • Irccs Ospedale San Martino

    Genova, 16132, Italy

  • Md Anderson Cancer Centre

    Madrid, 28033, Spain

  • Memorial Sloan-Kettering Cancer Center

    New York, New York, 10065, United States

  • National Cancer Center

    Goyang-si, 10408, South Korea

  • National Cancer Center Hospital

    Chūōku, 104-0045, Japan

  • National Cancer Center Hospital East

    Kashiwa, 277-8577, Japan

  • National Hospital Organization Kyushu Cancer Center

    Fukuoka, 811-1395, Japan

  • Northside Hospital

    Marietta, Georgia, 30060, United States

  • Osaka International Cancer Institute

    Osaka, 541-8567, Japan

  • Saitama Medical University International Medical Center

    Hidaka, 1397-1, Japan

  • Samsung Medical Center

    Seoul, 06351, South Korea

  • Severance Hospital

    Seoul, 03722, South Korea

  • Shanghai Cancer center

    Shanghai, 200000, China

  • The Cancer Institute Hospital of Jfcr

    Kōtoku, Japan

  • The Clínica Universidad de Navarra Madrid

    Madrid, 28027, Spain

  • The University of Texas MD Anderson Cancer Center

    Houston, Texas, 77030, United States

  • UZ Leuven Gynaec onco

    Leuven, 3000, Belgium

  • University of Michigan Comprehensive Cancer Center Michigan Medicine

    Ann Arbor, Michigan, 48109, United States

  • Vall d'Hebron University Hospital

    Barcelona, 08035, Spain

  • West Cancer Center and Research Institute

    Germantown, Tennessee, 38138, United States

  • Women's Cancer Care Associates

    Albany, New York, 12208, United States

  • ZAS Sint-Augustinus

    Wilrijk, 2610, Belgium