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New Antibody-Drug conjugate takes aim at Hard-to-Treat gynaecological cancers

NCT ID NCT05527184

Ongoing Disease control Sponsor: AbbVie Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-stage trial is testing a new drug called IMGN151 in 256 adults with recurrent gynaecological cancers, including ovarian, endometrial, and cervical cancers. The drug is an antibody-drug conjugate designed to deliver a cancer-killing agent directly to cells that have a specific marker (folate receptor alpha). The study's main goals are to check safety, find the right dose, and get an early look at whether the drug can shrink tumors.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

IMGN151 (an antibody-drug conjugate that targets folate receptor alpha on cancer cells)

What this could lead to

If it works, this could lead to a new treatment option for people with recurrent gynaecological cancers that have not responded to standard therapies.

What could go wrong

This is a very early Phase 1 trial, so the main goals are safety and dosing, not yet proving effectiveness. The drug may cause side effects or fail to shrink tumors in later studies.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

cervical cancer cervical carcinoma endometrial cancer endometrial carcinoma endometrium neoplasm fallopian tube cancer fallopian tube neoplasm ovarian serous adenocarcinoma primary peritoneal carcinoma Recurrence Uterine Cervical Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CERVICAL CANCER ENDOMETRIAL CANCER FALLOPIAN TUBE CANCER HIGH GRADE SEROUS ADENOCARCINOMA OF OVARY PRIMARY PERITONEAL CARCINOMA

Contacts and locations

Locations

  • AdventHealth Celebration /ID# 269030

    Kissimmee, Florida, 34747, United States

  • Atrium Health Levine Cancer Institute /ID# 269049

    Charlotte, North Carolina, 28204, United States

  • Azienda Ospedaliero Universitaria delle Marche /ID# 269018

    Ancona, 60020, Italy

  • BC Cancer - Kelowna /ID# 268983

    Kelowna, British Columbia, V1Y 5L3, Canada

  • Centre Antoine-Lacassagne /ID# 269000

    Nice, Provence-Alpes-Côte d'Azur Region, 06189, France

  • Centre Hospitalier De L'Universite De Montreal - Hopital Saint-Luc /ID# 268982

    Montreal, Quebec, H2X 3E4, Canada

  • Centre Hospitalier Universite De Sherbrooke - Hôtel-Dieu Hospital /ID# 268981

    Sherbrooke, Quebec, J1G 2E8, Canada

  • Centre Leon Berard /ID# 268993

    Lyon, Rhone, 69373, France

  • City of Hope National Medical Center /ID# 269036

    Duarte, California, 91010, United States

  • Columbia University Irving Medical Center /ID# 269033

    New York, New York, 10032, United States

  • Cross Cancer Institute /ID# 268984

    Edmonton, Alberta, T6G 1Z2, Canada

  • DKD Helios Klinik Wiesbaden /ID# 269011

    Wiesbaden, 65191, Germany

  • Dana-Farber Cancer Institute /ID# 269039

    Boston, Massachusetts, 02215, United States

  • Erasmus Medisch Centrum /ID# 269022

    Rotterdam, South Holland, 3015 CE, Netherlands

  • Florida Cancer Specialists- Sarasota Cattlemen /ID# 269055

    Sarasota, Florida, 34232, United States

  • Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Universita Cattolica /ID# 269020

    Rome, Roma, 00168, Italy

  • Hoag Memorial Hospital Presbyterian /ID# 269047

    Newport Beach, California, 92663, United States

  • Holy Name Medical Center /ID# 269051

    Teaneck, New Jersey, 07666, United States

  • Hospices Civils de Lyon - Centre Hospitalier Lyon-Sud /ID# 268996

    Pierre-Bénite, Rhone, 69310, France

  • Hospital Clínico Universitario de Valencia /ID# 268988

    Valencia, 46010, Spain

  • Hospital MD Anderson Cancer Center Madrid /ID# 268991

    Madrid, 28033, Spain

  • Hospital Universitario La Paz /ID# 268987

    Madrid, 28046, Spain

  • Hospital Universitario Ramón y Cajal /ID# 268992

    Madrid, 28034, Spain

  • Hospital Universitario Reina Sofia /ID# 269656

    Córdoba, Cordoba, 14004, Spain

  • Hospital Universitario Vall de Hebron /ID# 268986

    Barcelona, 08035, Spain

  • Hôpital Vivalia De Libramont /ID# 268979

    Libramont-Chevigny, Luxembourg, 6800, Belgium

  • Institut Català d'Oncologia (ICO) - Badalona /ID# 268990

    Badalona, Barcelona, 08916, Spain

  • Institut Gustave Roussy /ID# 268994

    Villejuif, Île-de-France Region, 94800, France

  • Institut de Cancerologie de Ouest /ID# 268997

    Saint-Herblain, Pays de la Loire Region, 44800, France

  • Karmanos Cancer Institute - Detroit /ID# 269052

    Detroit, Michigan, 48201, United States

  • Long Island Jewish Medical Center /ID# 269035

    New Hyde Park, New York, 11040, United States

  • MD Anderson Houston /ID# 269057

    Houston, Texas, 77030-4000, United States

  • Massachusetts General Hospital /ID# 278119

    Boston, Massachusetts, 02114, United States

  • Mater Misericordiae University Hospital /ID# 269013

    Dublin, D07 R2WY, Ireland

  • Miami Cancer Institute at Baptist Health /ID# 269041

    Miami, Florida, 33176, United States

  • Monash Health - Monash Medical Centre /ID# 268971

    Perth, Western Australia, 6000, Australia

  • Moores Cancer Center /ID# 269040

    La Jolla, California, 92037, United States

  • Mount Sinai Medical Center /ID# 269050

    Miami, Florida, 33140, United States

  • OU Health - Stephenson Cancer Center /ID# 269025

    Oklahoma City, Oklahoma, 73104, United States

  • Roswell Park Cancer Institute /ID# 269043

    Buffalo, New York, 14263, United States

  • Sanford Cancer Center /ID# 269038

    Sioux Falls, South Dakota, 57104, United States

  • Tennessee Oncology Nashville /ID# 269029

    Nashville, Tennessee, 37203, United States

  • The Ohio State University Comprehensive Cancer Center /ID# 269026

    Columbus, Ohio, 43210-1240, United States

  • UCHSC Anschultz Cancer Pavilion /ID# 269056

    Aurora, Colorado, 80045-2517, United States

  • Universitair Medisch Centrum Groningen /ID# 269023

    Groningen, 9713 GR, Netherlands

  • Universitair Medisch Centrum Utrecht /ID# 269024

    Utrecht, 3584 CX, Netherlands

  • Universitair Ziekenhuis Leuven /ID# 268977

    Leuven, Vlaams-Brabant, 3000, Belgium

  • University of Alabama at Birmingham /ID# 269045

    Birmingham, Alabama, 35233, United States

  • University of California Los Angeles Medical Center /ID# 269037

    Los Angeles, California, 90095, United States

  • University of Chicago Medical Center /ID# 269028

    Chicago, Illinois, 60637, United States

  • University of Mississippi Medical Cancer Center /ID# 269046

    Jackson, Mississippi, 39213, United States

  • University of North Carolina Medical Center /ID# 269027

    Chapel Hill, North Carolina, 27514, United States

  • University of Pennsylvania /ID# 269042

    Philadelphia, Pennsylvania, 19104, United States

  • University of Rochester Medical Center /ID# 269044

    Rochester, New York, 14642, United States

  • University of Virginia /ID# 269053

    Charlottesville, Virginia, 22908, United States

  • Washington University School of Medicine - St. Louis /ID# 269048

    St Louis, Missouri, 63130, United States

  • West Penn Hospital /ID# 269054

    Pittsburgh, Pennsylvania, 15224-1722, United States

  • Women & Infants Hospital /ID# 269032

    Providence, Rhode Island, 02905, United States