New drug INCB123667 enters human trials for Hard-to-Treat cancers

NCT ID NCT05238922

Ongoing Disease control Sponsor: Incyte Corporation Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 22, 2026 · Updated 2 times

Summary

This early-stage trial is testing a new drug called INCB123667, taken as a tablet, in people with advanced solid tumors that have not responded to standard treatments. The study will first test the drug alone, then in combination with other cancer therapies. The main goals are to check safety, find the right dose, and see early signs of whether the drug can shrink tumors.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: INCB123667 (a drug taken as a tablet)
What this could lead to: If successful, this could point toward a new treatment option for people with advanced solid tumors that have stopped responding to standard therapies.
What could go wrong: This is an early Phase 1 trial focused on safety and dosing, so it is very uncertain whether the drug will work. Side effects are unknown, and the study is not designed to prove effectiveness.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

breast neoplasm carcinoma of esophagus Carcinoma, Ovarian Epithelial Digestive System Neoplasms endometrial cancer fallopian tube cancer gastric carcinoma gastroesophageal junction adenocarcinoma hormone receptor-positive breast cancer metastatic malignant neoplasm neoplasm ovarian cancer primary peritoneal carcinoma triple-negative breast carcinoma uterine cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SOLID TUMORS

Contacts and locations

Locations

Aichi Cancer Center Hospital

Aichi, 464 8681, Japan
Allegheny Health Network

Pittsburgh, Pennsylvania, 15224, United States
Carolina Bio-Oncology Institute, Pllc

Huntersville, North Carolina, 28078, United States
Centre Hospitalier Universitaire Vaudois (Chuv)

Lausanne, 01011, Switzerland
Centre Leon Berard

Lyon, 69008, France
Centro Ricerche Cliniche Di Verona

Verona, 37134, Italy
City of Hope Medical Center

Duarte, California, 91010, United States
City of Hope-Lennar Foundation Cancer Center

Irvine, California, 92618, United States
Emory University

Atlanta, Georgia, 30322, United States
Erasmus Medical Center

Rotterdam, 3015 GD, Netherlands
Fondazione Irccs Istituto Nazionale Dei Tumori

Milan, 20133, Italy
Guys Hospital

London, SE1 9RT, United Kingdom
Imperial College Healthcare Nhs Trust - Hammersmith Hospital

London, W12 0HS, United Kingdom
Inselspital Universitatsklinik Fur Medizinische Onkologie

Bern, CH-3010, Switzerland
Institut Bergonie

Bordeaux, 33076, France
Institut Gustave Roussy

Villejuif, 94800, France
Irccs Istituto Clinico Humanitas

Rozzano, 20089, Italy
Istituto Nazionale Tumori Irccs Fondazione Pascale

Naples, 80131, Italy
Memorial Sloan Kettering Cancer Center

New York, New York, 10022, United States
Mount Sinai Medical Center Comprehensive Cancer Center

Miami Beach, Florida, 33140, United States
National Cancer Center Hospital

Tokyo, 104-0045, Japan
National Cancer Center Hospital East

Chiba-ken, 277-0882, Japan
Netherlands Cancer Institute Antoni Van Leeuwenhoek Ziekenhuis

Amsterdam, 1066 CX, Netherlands
New York Presbyterian/Weill Cornell

New York, New York, 10065, United States
Northern Centre For Cancer Care

Newcastle upon Tyne, NE7 7DN, United Kingdom
Ny Cancer and Blood Specialists

Shirley, New York, 11967, United States
Oncological Institute of Southern Switzerland

Bellinzona, 06500, Switzerland
Panoncology Trials Pan American Center For Oncology Trials, Llc

Rio Piedras, 00935, Puerto Rico
Policlinico Universitario Agostino Gemelli Universita Cattolica Del Sacro Cuore

Rome, 00168, Italy
Rocky Mountain Cancer Centers-Sky Ridge

Lone Tree, Colorado, 80124, United States
Saitama Medical University International Medical Center

Hidaka-shi, 350-1298, Japan
Tennessee Oncology

Nashville, Tennessee, 37203, United States
Texas Oncology-Fort Worth South Henderson

Fort Worth, Texas, 76104, United States
The Cancer Institute Hospital of Jfcr

Tokyo, 135-0063, Japan
Universitaire Du Cancer de Toulouse Institut Claudius Regaud Iuct-Oncopole

Toulouse, 31059, France
University of Pennsylvania Abramson Cancer Center

Philadelphia, Pennsylvania, 19104, United States
University of Pittsburgh Cancer Institute Cancer Services

Pittsburgh, Pennsylvania, 15213, United States
University of Wisconsin

Madison, Wisconsin, 53792, United States
Valkyrie Clinical Trials

Los Angeles, California, 90067, United States
Virginia Cancer Institute

Fairfax, Virginia, 22031, United States
Yale Cancer Center

New Haven, Connecticut, 06510, United States

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