New drug combo trial opens for Hard-to-Treat cancers

NCT ID NCT05238922

Recruiting now Disease control Sponsor: Incyte Corporation Source: ClinicalTrials.gov ↗

First seen Nov 03, 2025 · Last updated Apr 28, 2026 · Updated 27 times

Summary

This early-phase study tests a new drug called INCB123667, given alone or with other cancer therapies, for adults with advanced solid tumors that have stopped responding to standard treatments. The main goals are to check safety, find the right dose, and see early signs of tumor shrinkage. About 604 participants will join across multiple centers.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

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Locations

Aichi Cancer Center Hospital
RECRUITING

Aichi, 464 8681, Japan
Allegheny Health Network
NOT_YET_RECRUITING

Pittsburgh, Pennsylvania, 15224, United States
Carolina Bio-Oncology Institute, Pllc
COMPLETED

Huntersville, North Carolina, 28078, United States
Centre Hospitalier Universitaire Vaudois (Chuv)
RECRUITING

Lausanne, 01011, Switzerland
Centre Leon Berard
RECRUITING

Lyon, 69008, France
Centro Ricerche Cliniche Di Verona
RECRUITING

Verona, 37134, Italy
City of Hope Medical Center
RECRUITING

Duarte, California, 91010, United States
City of Hope-Lennar Foundation Cancer Center
RECRUITING

Irvine, California, 92618, United States
Cleveland Clinic
WITHDRAWN

Cleveland, Ohio, 44195, United States
Emory University
COMPLETED

Atlanta, Georgia, 30322, United States
Erasmus Medical Center
RECRUITING

Rotterdam, 3015 GD, Netherlands
Fondazione Irccs Istituto Nazionale Dei Tumori
RECRUITING

Milan, 20133, Italy
Guys Hospital
RECRUITING

London, SE1 9RT, United Kingdom
Imperial College Healthcare Nhs Trust - Hammersmith Hospital
RECRUITING

London, W12 0HS, United Kingdom
Inselspital Universitatsklinik Fur Medizinische Onkologie
RECRUITING

Bern, CH-3010, Switzerland
Institut Bergonie
RECRUITING

Bordeaux, 33076, France
Institut Gustave Roussy
RECRUITING

Villejuif, 94800, France
Irccs Istituto Clinico Humanitas
RECRUITING

Rozzano, 20089, Italy
Istituto Nazionale Tumori Irccs Fondazione Pascale
COMPLETED

Naples, 80131, Italy
Memorial Sloan Kettering Cancer Center
COMPLETED

New York, New York, 10022, United States
Mount Sinai Medical Center Comprehensive Cancer Center
RECRUITING

Miami Beach, Florida, 33140, United States
National Cancer Center Hospital
RECRUITING

Tokyo, 104-0045, Japan
National Cancer Center Hospital East
RECRUITING

Chiba-ken, 277-0882, Japan
Netherlands Cancer Institute Antoni Van Leeuwenhoek Ziekenhuis
RECRUITING

Amsterdam, 1066 CX, Netherlands
New York Presbyterian/Weill Cornell
COMPLETED

New York, New York, 10065, United States
Northern Centre For Cancer Care
RECRUITING

Newcastle upon Tyne, NE7 7DN, United Kingdom
Ny Cancer and Blood Specialists
NOT_YET_RECRUITING

Shirley, New York, 11967, United States
Oncological Institute of Southern Switzerland
RECRUITING

Bellinzona, 06500, Switzerland
Panoncology Trials Pan American Center For Oncology Trials, Llc
RECRUITING

Rio Piedras, 00935, Puerto Rico
Policlinico Universitario Agostino Gemelli Universita Cattolica Del Sacro Cuore
RECRUITING

Rome, 00168, Italy
Rocky Mountain Cancer Centers-Sky Ridge
RECRUITING

Lone Tree, Colorado, 80124, United States
Saitama Medical University International Medical Center
RECRUITING

Hidaka-shi, 350-1298, Japan
Tennessee Oncology
NOT_YET_RECRUITING

Nashville, Tennessee, 37203, United States
Texas Oncology-Fort Worth South Henderson
COMPLETED

Fort Worth, Texas, 76104, United States
The Cancer Institute Hospital of Jfcr
RECRUITING

Tokyo, 135-0063, Japan
Universitaire Du Cancer de Toulouse Institut Claudius Regaud Iuct-Oncopole
RECRUITING

Toulouse, 31059, France
University of Pennsylvania Abramson Cancer Center
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
University of Pittsburgh Cancer Institute Cancer Services
COMPLETED

Pittsburgh, Pennsylvania, 15213, United States
University of Wisconsin
NOT_YET_RECRUITING

Madison, Wisconsin, 53792, United States
Valkyrie Clinical Trials
RECRUITING

Los Angeles, California, 90067, United States
Virginia Cancer Institute
RECRUITING

Fairfax, Virginia, 22031, United States
Yale Cancer Center
COMPLETED

New Haven, Connecticut, 06510, United States

Conditions

Explore the condition pages connected to this study.

SOLID TUMORS SOLID TUMORS