New drug combo aims to shrink endometrial tumors

NCT ID NCT05548296

Recruiting now Disease control Sponsor: Acrivon Therapeutics Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase 2 trial tests an experimental drug called ACR-368, alone or with a low dose of gemcitabine, in 350 people with high-grade endometrial cancer. A special test (OncoSignature) helps decide which treatment arm a participant joins. The main goal is to see if the drug shrinks tumors.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ACR-368 (prexasertib) and ultra-low dose gemcitabine
What this could lead to: If successful, this could provide a new treatment option for people with high-grade endometrial cancer, especially those whose tumors are sensitive based on the OncoSignature test.
What could go wrong: This is a Phase 2 trial, so the drug is still experimental. It may not work for everyone, and side effects are possible. The OncoSignature test is also investigational.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

endometrial cancer endometrium adenocarcinoma endometrium neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ENDOMETRIAL ADENOCARCINOMA

Contacts and locations

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Locations

Alaska Women's Cancer Center
COMPLETED

Anchorage, Alaska, 99508, United States
American Oncology Partners of Maryland PA
COMPLETED

Bethesda, Maryland, 20817, United States
Arizona Oncology Associate, PC- HOPE
ACTIVE_NOT_RECRUITING

Tucson, Arizona, 85711, United States
Ascension St. Vicent Hospital, Inc.
RECRUITING

Indianapolis, Indiana, 46260, United States
CRO Aviano
NOT_YET_RECRUITING

Aviano, Italy
Carle Cancer Center
RECRUITING

Urbana, Illinois, 61801, United States
Cedars Sinai Medical Center
RECRUITING

Los Angeles, California, 90048, United States
Centre François Baclesse
RECRUITING

Caen, France
Centre Léon Bérard
RECRUITING

Lyon, France
City of Hope National Medical Center
RECRUITING

Duarte, California, 91010, United States
Cleveland Clinic Foundation
COMPLETED

Cleveland, Ohio, 44195, United States
Dana Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02115, United States
Emory University
RECRUITING

Atlanta, Georgia, 30322, United States
FirstHealth of the Carolinas
ACTIVE_NOT_RECRUITING

Pinehurst, North Carolina, 28374, United States
Florida Gynecologic Oncology/Regional Cancer Center
COMPLETED

Fort Myers, Florida, 33905, United States
Fondazione Pascale Istituto Tumori
NOT_YET_RECRUITING

Naples, Italy
Fox Chase Cancer Center
ACTIVE_NOT_RECRUITING

Philadelphia, Pennsylvania, 19111, United States
Fred Hutchinson Cancer Center
COMPLETED

Seattle, Washington, 98109, United States
Froedtert and Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Fundacion Instituto Valenciano de Oncologia (IVO)
NOT_YET_RECRUITING

Valencia, Spain
Gabrail Cancer Center
COMPLETED

Canton, Ohio, 44718, United States
HCA Midwest
RECRUITING

Kansas City, Missouri, 64132, United States
Hoag Cancer Center
RECRUITING

Newport Beach, California, 92663, United States
Holy Cross Hospital
COMPLETED

Silver Spring, Maryland, 20910, United States
HonorHealth
RECRUITING

Phoenix, Arizona, 85016, United States
Hospital Clínic de Barcelona
RECRUITING

Barcelona, Spain
Hospital Universitario 12 de Octubre
NOT_YET_RECRUITING

Madrid, Spain
Hospital Universitario La Paz
NOT_YET_RECRUITING

Madrid, Spain
Hospital Universitario Puerta de Hierro
NOT_YET_RECRUITING

Barcelona, Spain
Hospital Universitario Ramón y Cajal
NOT_YET_RECRUITING

Madrid, Spain
Humanitas University
NOT_YET_RECRUITING

Pieve Emanuele, Italy
Huntsman Cancer Institute, University of Utah
RECRUITING

Salt Lake City, Utah, 84112, United States
Insitute de Cancérologie de l'Ouest
RECRUITING

Saint-Herblain, France
Institut Català of Oncology (ICO)
NOT_YET_RECRUITING

Barcelona, Spain
Institute Gustave Roussy
RECRUITING

Villejuif, France
Istituto Clinico Cannizzaro Catania
NOT_YET_RECRUITING

Catania, Italy
Istituto Europeo di Oncologia
NOT_YET_RECRUITING

Milan, Italy
John Theurer Cancer Center at Hackensack University Medical Center
RECRUITING

Hackensack, New Jersey, 07601, United States
KEM | Evang. Kliniken Essen-Mitte
NOT_YET_RECRUITING

Essen, Germany
Karmanos Cancer Institute
RECRUITING

Detroit, Michigan, 48201, United States
LSU Health Sciences
RECRUITING

New Orleans, Louisiana, 70112, United States
Laura & Isaac Perlmutter Cancer Center
RECRUITING

New York, New York, 10016, United States
Memorial Sloan-Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
Miami Valley Hospital South
RECRUITING

Centerville, Ohio, 45459, United States
Mount Sinai Comprehensive Cancer Center
RECRUITING

Miami Beach, Florida, 33140, United States
Mount Sinai Health System
RECRUITING

New York, New York, 10128, United States
National Institutes of Health, Clinical Center
ACTIVE_NOT_RECRUITING

Bethesda, Maryland, 20892, United States
New York Presbyterian Hospital-Columbia University Medical Center
COMPLETED

New York, New York, 10032, United States
Northeast Georgia Medical Center
COMPLETED

Gainesville, Georgia, 30501, United States
Northwest Cancer Specialists, P.C.
COMPLETED

Vancouver, Washington, 98684, United States
Northwestern Medicine
RECRUITING

Chicago, Illinois, 60611, United States
Ohio State University
RECRUITING

Hilliard, Ohio, 43026, United States
Oncology Associates of Oregon
COMPLETED

Eugene, Oregon, 97401, United States
Oregon Health & Sciences University
COMPLETED

Portland, Oregon, 97239, United States
Ospedale Mauriziano Torino
NOT_YET_RECRUITING

Turin, Italy
Policlinico Gemelli
NOT_YET_RECRUITING

Roma, Italy
Providence Sacred Heart Medical Center and Children's Hospital
RECRUITING

Spokane, Washington, 99204, United States
Rutgers Cancer Institute of NJ
RECRUITING

New Brunswick, New Jersey, 08903, United States
Sanford Health
RECRUITING

Sioux Falls, South Dakota, 57104, United States
Stanford Cancer Center
RECRUITING

Palo Alto, California, 94304, United States
Stephenson Cancer Center at OU Health
RECRUITING

Oklahoma City, Oklahoma, 73104, United States
Summit Cancer Center
COMPLETED

Spokane, Washington, 99208, United States
Swedish Cancer Center
RECRUITING

Seattle, Washington, 98104, United States
Texas Oncology
COMPLETED

Fort Worth, Texas, 76104, United States
Texas Oncology-Dallas Presbyterian Hospital
COMPLETED

Dallas, Texas, 75231, United States
Trials365, LLC
RECRUITING

Shreveport, Louisiana, 71103, United States
UC Irvine Health
COMPLETED

Orange, California, 92868, United States
UC San Diego Moores Cancer Center
RECRUITING

La Jolla, California, 92037, United States
USC/Norris Comprehensive Cancer Center
COMPLETED

Los Angeles, California, 90033, United States
University of Arkansas for Medical Sciences
RECRUITING

Little Rock, Arkansas, 72205, United States
University of California Los Angeles (UCLA)
RECRUITING

Santa Monica, California, 90404, United States
University of California, Davis Comprehensive Cancer Center
RECRUITING

Sacramento, California, 95817, United States
University of Chicago Medicine
RECRUITING

Chicago, Illinois, 60637, United States
University of Cincinnati Cancer Center
RECRUITING

Cincinnati, Ohio, 45267, United States
University of Colorado
RECRUITING

Aurora, Colorado, 80045, United States
University of Illinois Cancer Center
RECRUITING

Chicago, Illinois, 60612, United States
University of Iowa
RECRUITING

Iowa City, Iowa, 52252, United States
University of Massachusetts Chan Medical School
COMPLETED

Worcester, Massachusetts, 01605, United States
University of North Carolina at Chapel Hill
COMPLETED

Chapel Hill, North Carolina, 27599, United States
University of Rochester Medical Center
RECRUITING

Rochester, New York, 14642, United States
University of South Alabama Mitchell Cancer Institute
COMPLETED

Mobile, Alabama, 36604, United States
University of Texas Southwestern Medical Center
COMPLETED

Dallas, Texas, 75390, United States
University of Texas, MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
University of Virginia Health System
RECRUITING

Charlottesville, Virginia, 22903, United States
Universitätsklinikum Münster, Klinik für Frauenheilkunde und Geburtshilfe
NOT_YET_RECRUITING

Münster, Germany
Universitätsklinikum Ulm, Frauenheilunde und Geburtshilfe
NOT_YET_RECRUITING

Ulm, Germany
Vall d'Hebron Institute of Oncology (VHIO)
RECRUITING

Barcelona, Spain
Virginia Commonwealth University
ACTIVE_NOT_RECRUITING

Richmond, Virginia, 23298, United States
West Penn Hospital
RECRUITING

Pittsburgh, Pennsylvania, 15224, United States
Women & Infants Hospital
RECRUITING

Providence, Rhode Island, 02905, United States

Contact Email: •••••@•••••
Yale Cancer Center
COMPLETED

New Haven, Connecticut, 06520, United States

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