New antibody cocktail takes on tough ovarian cancers
NCT ID NCT04590326
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests an experimental drug called REGN5668, alone or combined with other drugs, in people with ovarian, fallopian tube, peritoneal, or endometrial cancer. The trial has two parts: first to find the safest dose, then to see if the drug shrinks tumors. About 612 participants will take part.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
REGN5668 (a bispecific antibody) alone or combined with cemiplimab, fianlimab, ubamatamab, or sarilumab
What this could lead to
If successful, this could point toward a new treatment option for ovarian and related cancers that have not responded to standard therapy.
What could go wrong
This is an early-phase trial (Phase 1/2) focused on safety and dosing, so it is not yet known if the drug combination will effectively shrink tumors. Side effects may be significant, and the results may not apply to all patients.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Centre Francois Baclesse (CFB)
RECRUITINGCaen, Normandy, 14076, France
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Centre Georges Francois Leclerc
RECRUITINGDijon, Bourgogne-Franche-Comté, 21000, France
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Chao Family Comprehensive Cancer Center
RECRUITINGOrange, California, 92868, United States
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City of Hope Comprehensive Cancer Center
RECRUITINGDuarte, California, 91010, United States
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Ciudad Universitaria
RECRUITINGMadrid, 28040, Spain
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Dana Farber Cancer Institute Brookline Avenue
RECRUITINGBoston, Massachusetts, 02215, United States
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H. Lee Moffitt Cancer Center
COMPLETEDTampa, Florida, 33612, United States
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Hopital Lyon Sud
RECRUITINGPierre-Bénite, Auvergne-Rhône, 69310, France
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Hospital Clinico Universitario Santiago de Compostela
RECRUITINGSantiago de Compostela, A Coruna, 15706, Spain
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Hospital Universitario 12 de Octubre Universidad Complutense de Madrid UCM
RECRUITINGMadrid, 28041, Spain
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Hospital Universitario Fundacion Jimenez
RECRUITINGMadrid, 28040, Spain
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Institut Bergonie
RECRUITINGBordeaux, New Aquitaine, 33076, France
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Institut Catala dOncologia Girona
RECRUITINGGirona, 17007, Spain
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Institut Gustave Roussy
RECRUITINGVillejuif, 94805, France
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Karmanos Cancer Institute
RECRUITINGDetroit, Michigan, 48201, United States
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Massachusetts General Hospital
RECRUITINGBoston, Massachusetts, 02114, United States
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Memorial Sloan Kettering Cancer Center
RECRUITINGNew York, New York, 10065, United States
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Perelman School of Medicine at the University of Pennsylvania
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
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Robert H. Lurie Comprehensive Cancer Center of Northwestern University
RECRUITINGChicago, Illinois, 60611, United States
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Seattle Cancer Care Alliance at South Lake Union - G3630
RECRUITINGSeattle, Washington, 98109, United States
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The City of Hope Orange County Lennar Foundation Cancer Center
RECRUITINGIrvine, California, 92618, United States
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The Ohio State University Wexner Medical Center
RECRUITINGColumbus, Ohio, 43210, United States
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Universitair Ziekenhuis Leuven
RECRUITINGLeuven, Vlaams-Brabant, 3000, Belgium
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University of Chicago Medical Center
RECRUITINGChicago, Illinois, 60637, United States