Cloaked clot-buster: platelet coating may sharpen attack on arterial blockages
NCT ID NCT07712445
First seen Jul 17, 2026 · Last updated Jul 17, 2026
Summary
This study tests a new version of the clot-dissolving drug tenecteplase, coated with platelet membranes, to see if it targets blood clots more effectively. Researchers will apply the coated drug to blood clots made from samples taken from people with coronary artery disease and healthy volunteers. The goal is to measure how well the coated drug dissolves clots compared to the standard drug.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- platelet membrane-coated tenecteplase (PM-TNK)
- What this could lead to
- If successful, this could lead to a more targeted clot-dissolving treatment for arterial thrombosis, potentially reducing bleeding risks.
- What could go wrong
- This is a small, early lab-based study using blood samples, not a full clinical trial in patients. The coated drug may not work better in real-world conditions.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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The First Affiliated Hospital with Nanjing Medical University
RECRUITINGNanjing, Jiangsu, 210029, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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