ESOPHAGEAL CANCER

This study tested a two-step surgery for people with esophageal cancer who also had hardened arteries, which can increase the risk of a leak after the main cancer surgery. First, doctors performed a small laparoscopic procedure to prepare the stomach's blood supply. Then, 12-18 d…

This study compared two different minimally invasive surgery approaches for treating esophageal cancer. Researchers wanted to see which method—Ivor-Lewis or McKeown—had fewer complications, shorter recovery times, and better long-term results. The study involved 272 patients with…

This study tested a new three-drug combination (afuresertib, sintilimab, and chemotherapy) for people with advanced solid tumors that had stopped responding to prior immunotherapy. The goal was to find a safe, effective dose and see if this combination could help control cancer g…

This early-phase trial tested a new cell therapy for people with advanced gastrointestinal cancers that had stopped responding to standard treatments. Researchers collected a patient's own immune cells from a tumor, used CRISPR gene editing to remove a molecular 'brake' (CISH), a…

This large, completed Phase 3 trial tested whether adding two new immunotherapy drugs (atezolizumab and tiragolumab) to standard chemotherapy could better control advanced esophageal cancer that cannot be surgically removed. The study involved 461 patients and directly compared t…

This small, early-stage study tested a two-part treatment for advanced esophageal cancer that had spread. First, doctors used a short, intense course of targeted radiation on the main tumor in the esophagus. The goal was to 'wake up' the patient's own immune system to fight the c…

This study tested whether combining two chemotherapy drugs with two targeted antibody drugs was safe and effective for people with advanced HER2-positive stomach or esophageal cancer. It involved 37 adults whose cancer had spread and who had not received these specific drugs befo…

This study tested a new method for adjusting chemotherapy doses to prevent unplanned treatment delays. It involved 52 adults with cancers of the digestive system (like colorectal or stomach cancer) who were receiving a common chemotherapy regimen called FOLFOX. The goal was to se…

This study tested a type of internal radiation treatment called high-dose-rate brachytherapy for several cancers, including cervical, prostate, and breast cancer. Researchers placed temporary radiation sources directly into or near tumors to deliver a strong, focused dose. The ma…

This study tested whether a 4-week pre-surgery program was practical for older adults with esophageal cancer. The program aimed to improve patients' fitness, nutrition, and sleep before their operation to help them recover better. Researchers enrolled 15 patients to see if they c…

This study tested whether a special high-flow nasal oxygen device could help prevent low oxygen levels during sedated endoscopy procedures. It focused on 80 patients at high risk for obstructive sleep apnea who were undergoing stomach or colon exams. Researchers compared breathin…

This study aimed to understand how genetics influence a person's risk of developing esophageal and certain stomach cancers. Researchers collected and analyzed biological samples from over 7,700 participants, including people with cancer and healthy individuals from high- and low-…

This study followed over 30,000 people in China for years after they took part in trials testing vitamin and mineral supplements to prevent stomach and esophageal cancer. The goal was to see if the health benefits from the supplements lasted after people stopped taking them and t…

This study aimed to see if using MRI scans helps doctors more consistently outline esophageal tumors for radiation therapy. Researchers compared how five different radiation oncologists drew tumor boundaries using standard CT/PET scans versus scans that included MRI. The goal was…

This study aimed to understand if a tight, hard-to-pass tumor in the esophagus indicates more advanced cancer. Researchers observed 100 adults with esophageal cancer during their standard diagnostic procedures. They collected data to see if the physical tightness of the tumor see…

This study aimed to find biological markers in blood and tumor tissue that could help predict how patients with esophageal or rectal cancer will respond to treatment before they start it. Researchers collected samples from 160 patients who were scheduled to receive chemotherapy a…

This study tested whether new AI software could help doctors plan radiation therapy more accurately and quickly than traditional manual methods. Researchers compared three ways of outlining organs on CT scans from 500 patients with lung, breast, or esophageal cancer. The goal was…

This study aimed to discover why esophageal cancer is so common in a specific region of Iran. Researchers enrolled 50,000 adults to track their health over time, collecting information on their diet, lifestyle, and environment. The goal was to identify risk factors to help preven…

This study tested whether picture warning labels on alcohol, showing the cancer risks of drinking, are effective. Over 1,000 adults who drink regularly were shown different styles of warning labels online. Researchers measured if the labels caught their attention, changed their p…