ESOPHAGEAL CANCER

This study is testing whether adding an experimental drug called Q702 to an existing immunotherapy (pembrolizumab) can help control advanced cancers that have stopped responding to previous treatments. The trial will enroll 120 people with advanced esophageal, stomach, liver, or …

This is the first human study testing the safety of an experimental drug called AB598 in people with advanced cancers. The trial will enroll 40 participants with various cancers including lung, stomach, bladder, and breast cancer to determine safe dosage levels and monitor side e…

This study is testing whether adding an immunotherapy drug called sintilimab to standard chemotherapy before radiation treatment helps people with inoperable esophageal cancer live longer and keeps the cancer from coming back. Researchers will compare this new combination approac…

This study is testing a three-step treatment for people with advanced head and neck cancer that can be removed by surgery. First, patients receive a combination of three drugs (carboplatin, nab-paclitaxel, and durvalumab) to try to shrink the cancer. Then, they have surgery. Fina…

This study is testing if a special PET scan taken partway through radiation treatment can help doctors see how the cancer is responding. If the scan shows the tumor is shrinking, doctors could adjust the remaining radiation to better target the cancer and potentially spare more h…

This early-stage trial is testing the safety of a new treatment called ADP-A2M4CD8, which uses a patient's own modified immune cells to fight cancer. The study will enroll 120 adults with one of nine advanced cancers who have specific genetic markers. Researchers will give the ce…

This study compares two radiation therapy methods for treating esophageal cancer: proton beam therapy (a newer, more precise method) and standard intensity-modulated radiation therapy. Researchers want to see if the newer proton therapy helps patients live longer without their ca…

This early-phase study aims to find the safest, most effective dose of proton beam radiation when given with chemotherapy before surgery for locally advanced esophageal cancer. It will enroll about 30 patients who are candidates for surgery to test this combined approach. The mai…

This is an early-stage study testing the safety and optimal dose of a new treatment called LB1908, a type of CAR-T cell therapy, for adults with advanced cancers of the stomach, esophagus, or pancreas. The therapy involves collecting a patient's own immune cells, engineering them…

This study is testing whether adding an experimental drug called LBL-007 to a standard immunotherapy and chemotherapy combination works better for people with advanced esophageal cancer that cannot be removed by surgery. It will involve about 118 participants who have not yet rec…

This study is testing a personalized approach to control advanced esophageal cancer. It uses a blood test to find patients at high risk of the cancer coming back after standard treatment. Those high-risk patients then receive extra treatment with immunotherapy and chemotherapy to…

This early-stage study is testing whether immune cells from healthy donors, given along with two other drugs, are safe for people with advanced colorectal, stomach, or hard-to-treat blood cancers. The goal is to see if this combination helps the donor immune cells last longer in …

This early-stage trial is testing the safety and finding the right dose of a two-drug combination (naptumomab estafenatox and durvalumab) for people with advanced or metastatic solid tumors. It will enroll about 120 adults with one of many eligible cancer types, including breast,…

This is an early-stage study testing a new antibody drug called IMT-009 in people with advanced solid tumors or lymphomas that have stopped responding to standard treatments. The main goals are to find a safe dose, understand the side effects, and see if the drug helps shrink tum…

This early-stage study tests a personalized cell therapy for people with advanced solid tumors. Doctors collect a patient's own immune cells, genetically modify them in a lab to better recognize and attack cancer, then infuse them back into the patient. The main goals are to chec…

This study tests whether a combination of two drugs (trastuzumab deruxtecan and nivolumab) given for one year after surgery can help prevent cancer from returning in patients with HER2-positive esophageal or gastroesophageal junction cancer. The treatment is for patients who have…

This study is testing a new, swallowable capsule that collects cells from the esophagus to screen for cancer and pre-cancerous conditions. It aims to see if this simple, non-invasive tool is practical and acceptable for use in rural primary care clinics, where access to tradition…

This study is testing whether a special type of scan called PET/MRI can predict how well a patient's esophageal cancer will respond to chemotherapy and radiation given before surgery. Researchers will follow 121 patients with esophageal cancer, using these scans before, during, a…

This study is testing whether drinking cola can help relieve sudden food blockages in the esophagus of people with esophageal cancer. Researchers are comparing cola to standard care in 50 patients to see if it improves the chance of relief within 24 hours. The goal is to find a s…

This study looks back at the medical records of 230 patients to understand how different treatments for brain metastases from stomach or esophageal cancer affect survival. Researchers are comparing surgery, radiation, and combinations of these treatments. The goal is to find whic…

This study collects leftover tissue and blood samples from patients with various cancers to help researchers understand these diseases better. The samples come from patients already having medical procedures, using only material that would otherwise be discarded. Researchers will…