New scan could predict who benefits from esophageal cancer therapy

NCT ID NCT04359732

Ongoing Knowledge-focused Sponsor: IRCCS San Raffaele Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study explores whether a special PET/MRI scan can predict how well esophageal cancer responds to chemotherapy and radiation given before surgery. Researchers will scan 121 patients during treatment and compare the images with the actual tumor response seen after surgery. The goal is to find imaging markers that identify responders early, potentially guiding more personalized care.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: hybrid PET/MRI scan
What this could lead to: If successful, this could help doctors personalize treatment by identifying which patients respond well to chemo-radiation before surgery.
What could go wrong: This is an observational imaging study, not a treatment trial. It may not change outcomes directly, and results may not apply to all cancer types.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

esophageal cancer Esophageal Neoplasms gastroesophageal junction adenocarcinoma neoplasm of esophagus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ESOPHAGEAL CANCER ESOPHAGEAL NEOPLASMS

Contacts and locations

Locations

Deaprtment of Radiology, IRCCS Ospedale San Raffaele

Milan, 20132, Italy

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