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Immunotherapy before surgery shows promise for certain cancers

NCT ID NCT04795661

Ongoing Disease control Sponsor: Centre Leon Berard Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether giving immunotherapy before surgery can help people with MSI/dMMR tumors. The goal is to shrink or eliminate the tumor before it is removed, potentially improving survival. The trial includes adults with localized, resectable cancers such as colorectal, gastric, or other MSI/dMMR tumors.

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Conditions

The condition(s) this trial relates to.

colon carcinoma esophageal cancer gastric cancer gastroesophageal junction adenocarcinoma neoplasm rectal cancer small intestine adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LOCALIZED RESECTABLE TUMOR MSI/DMMR

Contacts and locations

Locations

  • APHP - Hôpital Saint-Antoine

    Paris, 75571, France

  • APHP Hôpital Saint-Louis

    Paris, 75010, France

  • CHU Amiens Picardie

    Amiens, 80054, France

  • CHU Clermont-Ferrand

    Clermont-Ferrand, 63003, France

  • CHU Poitiers

    Poitiers, 86021, France

  • CHU Saint Etienne

    Saint-Etienne, 42270, France

  • Centre Antoine Lacassagne

    Nice, 06189, France

  • Centre Eugène Marquis

    Rennes, 35042, France

  • Centre Georges-Francois Leclerc

    Dijon, 21079, France

  • Centre Léon Bérard

    Lyon, 69008, France

  • Centre Paul Strauss

    Strasbourg, 67200, France

  • Groupe Hospitalier Diaconesses Croix Saint-Simon

    Paris, 75571, France

  • Hopital Huriez

    Lille, 59037, France

  • Hôpital Européen Georges Pompidou

    Paris, 75015, France

  • Institut Paoli Calmettes

    Marseille, 13273, France

  • Institut de cancérologie Strasbourg Europe

    Strasbourg, 67200, France

  • Institut du Cancer Val d'Aurelle

    Montpellier, 34298, France

  • Institut mutualiste Montsouris

    Paris, 75014, France

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