Immunotherapy combo before chemo-radiation shows promise for esophageal cancer

NCT ID NCT03044613

First seen Apr 09, 2026 · Last updated Jun 13, 2026 · Updated 14 times

Summary

This study tests whether giving immunotherapy drugs (nivolumab alone or with relatlimab) before standard chemoradiation is safe and feasible for people with operable stage II/III esophageal or gastroesophageal junction cancer. About 32 adults will receive the drugs, then chemoradiation, followed by surgery. The goal is to see if this approach changes the tumor's environment and improves survival without causing major delays in surgery.

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Contacts and locations

Locations

  • Alleghany Health Network

    Pittsburgh, Pennsylvania, 15212, United States

  • Baylor University/ Charles A. Sammons Cancer Center

    Dallas, Texas, 75246, United States

  • Johns Hopkins University

    Baltimore, Maryland, 21287, United States

Conditions

Explore the condition pages connected to this study.