New drug BT8009 targets Hard-to-Treat cancers in early trial

NCT ID NCT04561362

First seen Nov 01, 2025 · Last updated May 16, 2026 · Updated 26 times

Summary

This study tests a new drug called BT8009, alone or with another drug (pembrolizumab), in people with advanced solid tumors that have a protein called Nectin-4. The goal is to see if the drug is safe and shrinks tumors. About 329 adults with cancers like bladder, breast, lung, or ovarian cancer are taking part.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Advent Health

    Orlando, Florida, 34747, United States

  • Centre Eugene Marquis

    Rennes, 35042, France

  • Centre Leon Berard

    Lyon, 69373, France

  • Fondazione IRCCS Istituto Nazionale dei Tumori

    Milan, MI, 20133, Italy

  • Hospital Clinic de Barcelona

    Barcelona, 08036, Spain

  • Hospital Universitario Marques de Valdecilla

    Santander, 39008, Spain

  • Icahn School of Medicine at Mount Sinai

    New York, New York, 10029, United States

  • Institut Bergonie

    Bordeaux, 33076, France

  • Institut Gustave Roussy

    Villejuif, 94805, France

  • Institut Paoli-Calmettes

    Marseille, 13009, France

  • Mary Crowley Cancer Research Center

    Dallas, Texas, 75230, United States

  • Next Oncology - Hospital Quironsalud Madrid

    Pozuelo de Alarcón, 28223, Spain

  • Ocala Oncology Center

    Ocala, Florida, 34474, United States

  • Ospedale San Raffaele

    Milan, 20132, Italy

  • START Madrid Fundacion Jimenez Diaz

    Madrid, 28040, Spain

  • Sarah Cannon Research Institute UK

    London, W1G 6AD, United Kingdom

  • Sarah Cannon Research Institute at HealthONE

    Denver, Colorado, 80218, United States

  • Tennessee Oncology, PLLC

    Nashville, Tennessee, 37203, United States

  • The Christie NHS Foundation Trust

    Manchester, M20 4BX, United Kingdom

  • The University of Texas MD Anderson Cancer Center

    Houston, Texas, 77030, United States

  • Thomas Jefferson University, Sidney Kimmel Cancer Center

    Philadelphia, Pennsylvania, 19107, United States

  • University Health Network, Princess Margaret Cancer Centre

    Toronto, Ontario, M5G IZ5, Canada

  • University Hospitals Cleveland Medical Center

    Cleveland, Ohio, 44106, United States

  • Vall d'Hebron Institute of Oncology

    Barcelona, 08035, Spain

Conditions

Explore the condition pages connected to this study.