Engineered immune cells take aim at multiple cancers in early trial

NCT ID NCT03132922

Ongoing Disease control Sponsor: USWM CT, LLC Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase study tests a personalized cell therapy for people with certain cancers (bladder, melanoma, head/neck, ovarian, lung, esophageal, stomach, or sarcoma) whose tumors have a specific marker called MAGE-A4. The treatment involves taking a patient's own immune cells, engineering them to better recognize and attack the cancer, and infusing them back. The main goals are to check safety and see if the therapy shrinks tumors.

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Conditions

The condition(s) this trial relates to.

adenocarcinoma esophageal cancer Esophageal Neoplasms gastric cancer gastric neoplasm gastroesophageal junction adenocarcinoma head and neck cancer Head and Neck Neoplasms melanoma myxoid liposarcoma myxoid/round cell liposarcoma Neoplasm Metastasis non-small cell lung carcinoma ovarian cancer sarcoma synovial sarcoma urinary bladder cancer Urinary Bladder Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ESOPHAGEAL CANCER GASTRIC CANCER GASTROESOPHAGEAL JUNCTION HEAD AND NECK CANCER MELANOMA MYXOID/ROUND CELL LIPOSARCOMA NON-SMALL CELL LUNG CANCER OVARIAN CANCER SYNOVIAL SARCOMA URINARY BLADDER CANCER

Contacts and locations

Locations

Duke University Medical Center, Duke Cancer Institute

Durham, North Carolina, 27710, United States
Fox Chase Cancer Center

Philadelphia, Pennsylvania, 19111, United States
M.D. Anderson Cancer Center

Houston, Texas, 77030, United States
Moffitt Cancer Center

Tampa, Florida, 33612, United States
Ohio State University Wexner Medical Center

Columbus, Ohio, 43210, United States
Princess Margaret Cancer Centre

Toronto, Ontario, M5G1X6, Canada
Roswell Park Cancer Institute

Buffalo, New York, 14263, United States
Tennessee Oncology - Sarah Cannon Research Institute

Nashville, Tennessee, 37203, United States
University of Miami

Miami, Florida, 33136, United States
Washington University

St Louis, Missouri, 63112, United States
Washington University School of Medicine

St Louis, Missouri, 63110, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.