New cancer drug enzelkitug enters first human trials
NCT ID NCT05581004
First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 4 times
Summary
This early-phase trial is testing a new drug called enzelkitug, alone or with standard immunotherapies, in people with advanced solid tumors that have not responded to other treatments. The main goals are to check safety, find the right dose, and see if the drug shrinks tumors. About 450 participants with various cancers like lung, melanoma, and breast cancer are being enrolled.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- enzelkitug (a drug, also called RO7502175), given alone or with atezolizumab or pembrolizumab
- What this could lead to
- If it works, this could point toward a new treatment option for several advanced cancers that are hard to treat.
- What could go wrong
- This is a very early (first-in-human) trial, so safety and the right dose are still unknown. Many early cancer drugs do not end up working in larger studies.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Asan Medical Center - PPDS
Seoul, 05505, South Korea
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British Columbia Cancer Agency
Vancouver, British Columbia, V5Z 4E6, Canada
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CHU de Liège
Herstal, 4040, Belgium
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Dana Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Florida Cancer Specialists - Sarasota
Sarasota, Florida, 34232, United States
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GasthuisZusters Antwerpen
Wilrijk, 2610, Belgium
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Het Nederlands Kanker Instituut Antoni Van Leeuwenhoek Ziekenhuis
Amsterdam, 1066 CX, Netherlands
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Hospital Clinico Universitario de Valencia
Valencia, 46010, Spain
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Hospital Universitario 12 De Octubre
Madrid, 28041, Spain
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Hospital Universitario Virgen de la Victoria
Málaga, 29010, Spain
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ICO l?Hospitalet ? Hospital Duran i Reynals
L'Hospitalet de Llobregat, Barcelona, 08908, Spain
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IDS (IDS) Pharmacist South Texas Accelerated Resear Therapeutics, LLC START
San Antonio, Texas, 78229, United States
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Instituto de Investigacion Oncologica Vall dHebron (VHIO) - EPON
Barcelona, 08035, Spain
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Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung City, 807, Taiwan
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Karolinska Universitetssjukhuset Solna
Stokholm, Solna, 17176, Sweden
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Kinghorn Cancer Centre
Darlinghurst, New South Wales, 2010, Australia
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Linear Clinical Research Ltd
Nedlands, Western Australia, 6009, Australia
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Monash Health Monash Medical Centre
Clayton, Victoria, 3168, Australia
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Ottawa Hospital Regional Cancer Centre
Ottawa, Ontario, K1H 8L6, Canada
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Princess Margaret Cancer Centre
Toronto, Ontario, M5G 1Z5, Canada
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Rutgers Cancer Institute of New Jersey
New Brunswick, New Jersey, 08901, United States
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SCRI Oncology Partners
Nashville, Tennessee, 37203, United States
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START MADRID_Hospital Universiario Fundacion Jimenez Diaz
Madrid, 28040, Spain
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Samsung Medical Center - PPDS
Seoul, 06351, South Korea
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Seoul National University Hospital
Seoul, 03080, South Korea
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Severance Hospital Yonsei University Health System - Clinical Trials Center Pharmacy
Seoul, 120-752, South Korea
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Sir Mortimer B Davis Jewish General Hospital
Montreal, Quebec, H3T 1E2, Canada
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Sotiria Thoracic Diseases Hospital of Athens
Athens, 115 27, Greece
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Stanford University
San Francisco, California, 94305, United States
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The West Clinic - Memphis (Union Ave)
Germantown, Tennessee, 38138, United States
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UZ Antwerpen
Edegem, 2650, Belgium
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Universitair Medisch Centrum Groningen
Groningen, 9713 GZ, Netherlands
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University General Hospital ''ATTIKON'' - General Hospital of West Attica H AGIA VARVARA
Chaïdári, Attica, 124 62, Greece
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University Of Colorado
Aurora, Colorado, 80045, United States
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Washington University Medical Center, Division of Oncology
St Louis, Missouri, 63110, United States
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Winship Cancer Institute
Atlanta, Georgia, 30322, United States
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