HCC

This study tests a radiation treatment (Y90) to help grow the liver in people with liver cancer who need surgery but don't have enough healthy liver left. The goal is to make surgery possible and improve survival. About 104 participants will receive either standard or optimized Y…

This study tests a new way to give radiation for liver cancer that uses real-time MRI to guide the beam and adjust the plan during a single treatment session. It aims to improve survival and reduce side effects compared to standard radiation. The trial is for adults with certain …

This study tests whether treating donor livers with a special oxygen-rich cold fluid (HOPE) before transplant can help prevent liver cancer from coming back. About 220 adults with liver cancer and cirrhosis who are waiting for a liver transplant will take part. Half of the donate…

This study tests a combination of drugs (cabozantinib, ipilimumab, nivolumab) and a procedure called TACE in 35 adults with liver cancer that cannot be removed by surgery or treated with a transplant. The goal is to see if this approach can stop the cancer from growing for at lea…

This study tests whether adding two immunotherapy drugs (durvalumab and tremelimumab) to a procedure called Y-90 SIRT (tiny radioactive beads placed in the liver) can shrink intermediate-stage liver cancer that cannot be removed by surgery. About 55 adults with this type of liver…

This study tests a treatment for liver cancer that cannot be removed by surgery. It uses tiny radioactive beads (yttrium-90) alone or combined with immunotherapy (camrelizumab) and/or a targeted drug (apatinib). The goal is to see if these combinations work better than the standa…

This study tests whether adding targeted radiation (SBRT) to standard immunotherapy (atezolizumab plus bevacizumab) can improve survival in people with advanced liver cancer that has spread into the main portal vein. About 40 adults with this aggressive condition will receive the…

This study is testing a new drug, enzelkitug, for people with advanced solid tumors that have spread or cannot be removed by surgery. The trial includes many cancer types like lung, head and neck, melanoma, breast, and others. The main goal is to check the drug's safety and find …

This study tests whether adding targeted radiation (SBRT) to spots where liver cancer has started growing again can help patients continue benefiting from immunotherapy. About 30 adults with advanced liver cancer that has progressed in a few places while on first-line immunothera…

This study tests a new drug, FOG-001, in about 595 people with advanced solid tumors that have not responded to other treatments. The goal is to see if FOG-001 is safe and can shrink tumors or slow their growth. The trial focuses on several cancer types, including colorectal, pro…

This study tests whether contrast-enhanced ultrasound (CEUS) can more accurately show if liver cancer has been killed by a targeted radiation treatment called TARE. Standard CT or MRI scans often take months to give clear results, delaying next steps. Researchers will enroll 30 a…

This study looks at how certain genes increase the risk of liver cancer (hepatocellular carcinoma) in people with nonalcoholic fatty liver disease (NAFLD). Researchers will follow 500 adults aged 45-75 with NAFLD to understand genetic factors and develop a risk score. The goal is…

This study looks at how a person's genes and their environment (like drinking alcohol) work together to cause liver cancer in people with alcohol-related liver disease. Researchers will study 1,000 participants to find new genetic variants that increase cancer risk. The goal is t…

This study tests a program called HCC Liver-Link designed to help Black patients with early-stage liver cancer get faster access to treatments like transplant or surgery. The program includes education, social support, and help connecting to cancer specialists. Forty participants…