HCC

This study is testing whether combining two immunotherapy drugs (durvalumab and tremelimumab) with a targeted internal radiation treatment (Y-90 SIRT) is safe and effective for people with intermediate-stage liver cancer that cannot be removed by surgery. The goal is to see if th…

This study is testing whether adding focused radiation therapy can help control advanced liver cancer that has started to progress in a few spots while patients are on standard immunotherapy. Researchers want to see if zapping these specific progressing areas with radiation can h…

This study is testing a combination of treatments for liver cancer that cannot be removed by surgery. It compares a targeted radiation injection, given alone or with two other drugs (an immunotherapy and a targeted therapy), against the current standard procedure (chemoembolizati…

This study is for people with liver cancer (HCC) who need surgery to remove their tumor but currently don't have enough healthy liver tissue left to safely undergo the operation. Researchers are testing a treatment called Y90 radioembolization, where tiny radioactive beads are in…

This is an early-stage study to test the safety and initial effectiveness of a new drug called RO7502175 for people with advanced solid tumors that have spread or cannot be cured. The drug will be tested both by itself and combined with other approved cancer drugs. The main goals…

This is an early-stage study to test the safety of a new type of immune cell therapy (CAR-T) for people with advanced liver cancer that has come back or hasn't responded to standard treatments. Researchers will give a small number of participants modified immune cells designed to…

This study is testing a new support program designed to help Black patients with early-stage liver cancer get faster access to potentially curative treatments like surgery or transplant. The program provides education, helps with social needs, and connects patients to cancer spec…

This study is testing if adding a precise, high-dose radiation treatment (SBRT) to a standard two-drug immunotherapy regimen can help people with advanced liver cancer that has spread into a major vein. The vein blockage makes the cancer much harder to treat and drastically short…

This early-stage trial is testing a new drug called FOG-001 for people with advanced or spreading cancers that have specific genetic mutations. Researchers want to find the safest dose and see if the drug can shrink tumors or slow cancer growth. The study will include 575 partici…

This study is testing a new, faster way to deliver precise radiation treatment for liver cancer. It uses real-time MRI scans to guide the radiation beam and aims to complete the entire treatment in a single session, without needing a separate planning scan. The main goal is to se…

This international study is testing if a new machine treatment for donor livers can help prevent liver cancer from coming back after a transplant. The machine, called HOPE, pumps a cold, oxygen-rich fluid through the liver before surgery. Researchers will compare this method to t…

This study is testing if a special type of ultrasound, called contrast-enhanced ultrasound (CEUS), can better check if a liver cancer treatment is working. It will compare CEUS to the standard CT or MRI scans that patients already get. The goal is to see if CEUS can give doctors …

This study aims to understand why some people with fatty liver disease develop liver cancer. Researchers will study 500 adults with fatty liver disease to see how specific genes and family history affect cancer risk. The goal is to create a tool to identify high-risk individuals …

This study aims to understand how a person's genes and their alcohol consumption interact to increase the risk of developing liver cancer. Researchers will analyze genetic data from 1,000 people with liver disease to identify specific genetic markers. The goal is to build a bette…