New combo therapy shows promise for Hard-to-Treat cancers

NCT ID NCT04078295

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new drug combination (E7389 liposomal formulation plus nivolumab) in 125 people with advanced solid tumors that have not responded to standard treatments. The goal is to find the safest dose and see if the combination can shrink tumors. The study is for people with certain cancers like gastric, esophageal, or small cell lung cancer.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

esophageal cancer gastric cancer neoplasm small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Eisai Trail Site #16

    Sunto-g, Shizuo, Japan

  • Eisai Trial Site #1

    Chuo Ku, Tokyo, Japan

  • Eisai Trial Site #10

    Koto-Ku, Tokyo, Japan

  • Eisai Trial Site #11

    Akashi, Hyōgo, Japan

  • Eisai Trial Site #12

    Kōtoku, Japan

  • Eisai Trial Site #13

    Nagoya, Aichi-ken, Japan

  • Eisai Trial Site #14

    Matsuya, Ehime, Japan

  • Eisai Trial Site #15

    Yokohama, Kanaga, Japan

  • Eisai Trial Site #17

    Suita, Osaka, Japan

  • Eisai Trial Site #18

    Kashiwa, Chiba, Japan

  • Eisai Trial Site #19

    Kitaadachi-gun, Saitama, Japan

  • Eisai Trial Site #2

    Kashiwa, Chiba, Japan

  • Eisai Trial Site #3

    Sendai, Miyagi, Japan

  • Eisai Trial Site #4

    Kurume, Fukuoka, Japan

  • Eisai Trial Site #5

    Osakasa, Osaka, Japan

  • Eisai Trial Site #6

    Chuo Ku, Osaka, Japan

  • Eisai Trial Site #7

    Sakai C, Osaka, Japan

  • Eisai Trial Site #8

    Chuo Ku, Osaka, Japan

  • Eisai Trial Site #9

    Wakayama, Wakaya, Japan