New trial aims to delay prostate cancer progression with targeted local therapy

NCT ID NCT04787744

Recruiting now Disease control Sponsor: VA Office of Research and Development Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study for veterans with prostate cancer that has returned in a few spots (oligorecurrence) compares standard systemic therapy alone versus standard therapy plus PET-directed local treatment using surgery or radiation. The goal is to see if adding local therapy delays the cancer from becoming resistant to hormone therapy. About 464 participants will be enrolled across multiple VA centers.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: PET-directed local therapy (surgery or radiation)
What this could lead to: If successful, this approach could help men with recurrent prostate cancer delay the need for stronger hormone therapy and maintain a better quality of life for longer.
What could go wrong: This is a mid-stage trial, so results are not yet proven. Adding local therapy may increase side effects without improving outcomes, and the benefit may vary depending on the number and location of metastases.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

metastatic prostate carcinoma Neoplasm Metastasis prostate cancer prostate carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DE NOVO PROSTATE CANCER METASTATIC PROSTATE CANCER OLIGOMETASTASIS OLIGORECURRENCE PROSTATE CANCER RECURRENT PROSTATE CANCER

Contacts and locations

Locations

Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD
RECRUITING

Baltimore, Maryland, 21201, United States
Bay Pines VA Healthcare System, Pay Pines, FL
RECRUITING

Bay Pines, Florida, 33744, United States
Clement J. Zablocki VA Medical Center, Milwaukee, WI
RECRUITING

Milwaukee, Wisconsin, 53295-1000, United States
Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA
RECRUITING

Philadelphia, Pennsylvania, 19104-4551, United States
Durham VA Medical Center, Durham, NC
RECRUITING

Durham, North Carolina, 27705, United States
East Orange Campus of the VA New Jersey Health Care System, East Orange, NJ
TERMINATED

East Orange, New Jersey, 07018, United States
Edward Hines Jr. VA Hospital, Hines, IL
RECRUITING

Hines, Illinois, 60141-3030, United States
Hunter Holmes McGuire VA Medical Center, Richmond, VA
RECRUITING

Richmond, Virginia, 23249, United States
Kansas City VA Medical Center, Kansas City, MO
TERMINATED

Kansas City, Missouri, 64128-2226, United States
Louis Stokes VA Medical Center, Cleveland, OH
RECRUITING

Cleveland, Ohio, 44106, United States
Michael E. DeBakey VA Medical Center, Houston, TX
RECRUITING

Houston, Texas, 77030, United States
Minneapolis VA Health Care System, Minneapolis, MN
ACTIVE_NOT_RECRUITING

Minneapolis, Minnesota, 55417-2309, United States
Richard L. Roudebush VA Medical Center, Indianapolis, IN
RECRUITING

Indianapolis, Indiana, 46202-2884, United States
VA Ann Arbor Healthcare System, Ann Arbor, MI
RECRUITING

Ann Arbor, Michigan, 48105, United States
VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA
RECRUITING

Boston, Massachusetts, 02130, United States
VA Greater Los Angeles Healthcare System, West Los Angeles, CA
RECRUITING

West Los Angeles, California, 90073, United States
VA Long Beach Healthcare System, Long Beach, CA
RECRUITING

Long Beach, California, 90822, United States
VA NY Harbor Healthcare System, New York, NY
TERMINATED

New York, New York, 10010-5011, United States
Washington DC VA Medical Center, Washington, DC
RECRUITING

Washington D.C., District of Columbia, 20422-0001, United States
William S. Middleton Memorial Veterans Hospital, Madison, WI
RECRUITING

Madison, Wisconsin, 53705-2254, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.