New drug cocktail aims to wipe out aggressive prostate cancer before surgery

NCT ID NCT05593497

Recruiting now Disease control Sponsor: VA Office of Research and Development Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 trial tests whether adding the targeted drug capivasertib to standard hormone therapy can shrink or destroy high-risk prostate tumors before surgery. The study enrolls 30 men with PTEN-loss prostate cancer, a marker of resistance to standard treatment. Participants receive the drug combination for 16 weeks, then undergo prostate removal to check for complete or near-complete cancer clearance.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Capivasertib (a targeted drug) combined with abiraterone and leuprolide (hormone therapies)
What this could lead to: If successful, this combination could shrink or eliminate high-risk prostate tumors before surgery, potentially improving long-term outcomes for patients with PTEN loss.
What could go wrong: This is a small early-phase trial with only 30 participants, so results may not apply broadly. The drug combination may cause side effects, and it's unclear if it will outperform standard treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

prostate cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIGH RISK PROSTATE CANCER

Contacts and locations

Locations

James J. Peters VA Medical Center, Bronx, NY
RECRUITING

The Bronx, New York, 10468-3904, United States
Ralph H. Johnson VA Medical Center, Charleston, SC
RECRUITING

Charleston, South Carolina, 29401-5703, United States
South Texas Health Care System, San Antonio, TX
TERMINATED

San Antonio, Texas, 78229-4404, United States
VA Greater Los Angeles Healthcare System, West Los Angeles, CA
RECRUITING

West Los Angeles, California, 90073-1003, United States
VA Portland Health Care System, Portland, OR
RECRUITING

Portland, Oregon, 97207-2964, United States
VA Puget Sound Health Care System Seattle Division, Seattle, WA
RECRUITING

Seattle, Washington, 98108-1532, United States

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