Va Office Of Research And Development

This completed study tested whether a customizable texting program could help veterans with type 2 diabetes improve their blood sugar control. 366 veterans were randomly assigned to receive either standard daily diabetes texts or a more interactive version with check-ins, medicat…

This study tests whether a computer-assisted tool helps mental health providers in rural VA clinics deliver cognitive behavioral therapy (CBT) more effectively for depression and anxiety. About 34 therapists and 167 veterans will take part. Therapists are randomly assigned to use…

This completed study tested a remote, self-guided lifestyle program for 696 veterans with obesity and obstructive sleep apnea. Participants watched videos, completed handouts, and tracked their eating and activity, with optional coaching. The goal was to see if this low-cost appr…

This study tested a weight-loss program called CoachToFit for 257 veterans with serious mental illness (like schizophrenia or bipolar disorder) who were obese. Participants used a smartphone app, an activity tracker, and a Bluetooth scale, and worked with a peer coach. The goal w…

This study looked at whether giving extra education and encouragement to diabetic foot ulcer patients helps them wear their prescribed walking boot more often. The boot is standard care, but many patients don't wear it enough. The study enrolled 18 veterans and measured boot wear…

This study tested a telehealth program for 30 veterans who misuse alcohol and have high blood pressure or other heart risks. The program included four video therapy sessions to reduce drinking, a coaching call to plan heart-healthy steps, and daily text messages for a month. The …

This study tested a program to help veterans with heart disease or rheumatic conditions take their medications as prescribed. Over 5,000 participants received reminders via text or phone calls, with extra support if needed. The goal was to improve medication adherence and reduce …

This study tested whether a 12-week high-intensity exercise program could slow aging and reduce inflammation in 89 older veterans living with HIV. Participants exercised via video conferencing without needing special equipment. The goal was to improve fitness and quality of life,…

This study tested a mental strategy called WOOP (Wish, Outcome, Obstacle, Plan) to help veterans with obesity lose weight. Over 400 veterans were split into two groups: one got the VA's standard weight program (MOVE!) plus WOOP, the other got MOVE! alone. The goal was to see if a…

This study tested a blended collaborative care model that uses telemedicine to integrate mental health treatment into primary care at smaller VA clinics serving rural veterans. Researchers enrolled 318 veterans who screened positive for depression, alcohol use disorder, or PTSD. …

This study tested whether a small wearable sensor, combined with a smart computer program, could detect early signs of worsening heart failure and alert doctors to adjust treatment before a hospital stay is needed. Researchers enrolled 176 veterans with heart failure and randomly…

This small pilot study tested two ways to stimulate the spinal cord—one with a surgically implanted device and one with surface electrodes—combined with a robotic exoskeleton to help people with spinal cord injury walk. Four men with complete paralysis below the chest took part. …

This study looked at whether testosterone therapy can improve bone health in men who have both type 2 diabetes and low testosterone. About 92 male veterans aged 35 to 70 took part. Researchers measured bone strength using special scans and blood tests over 12 months to see if tes…

This study tested whether adding the antibiotic rifampin to standard treatment helps prevent amputations in diabetic patients with foot bone infections. Over 800 veterans participated, receiving either rifampin or a placebo for six weeks. The goal was to see if rifampin improves …

This study tested whether a program of diet, aerobic exercise, and balance training could improve nerve function and balance in people with prediabetes or early type 2 diabetes. About 61 participants were assigned to either the program or standard care. The goal was to see if the…

This study tested a new therapy called TR&ST that involves both a veteran at risk for suicide and their romantic partner. The goal was to see if working together as a couple could reduce suicidal thoughts more than standard VA care. The study included 104 veterans and their partn…

This study tested a checklist to prevent MRSA surgical site infections in over 23,000 veterans undergoing joint replacement or heart surgery. The checklist included using antibiotic ointment and antiseptic baths before surgery, plus antibiotics during surgery. Researchers measure…

This study tested whether a gentle brain stimulation technique called tDCS, combined with cognitive training, could improve thinking skills and reduce relapse in veterans with alcohol use disorder. 45 veterans received either real or sham tDCS during cognitive exercises. The goal…

This study tested whether long-term aerobic walking can slow the progression of Parkinson's disease. 57 people with mild-to-moderate Parkinson's walked for 150 minutes per week at a moderate pace. Researchers measured changes in movement, thinking, driving safety, and brain healt…

People with spinal cord injury (SCI) face higher risks of heart disease and diabetes, partly due to chronic inflammation and poor blood vessel function. Exercise helps but is often not possible. This small study tested whether repeated passive heating (using a water-perfused suit…

This study tested whether a person with chronic paralysis from a spinal cord injury could control hand movements using only their thoughts. The participant, who already had a brain implant from the BrainGate study, used a computer to decode their intended grasp patterns. Those si…

This study tested whether ibudilast, a drug that reduces brain inflammation, can help people addicted to methamphetamine. 176 participants took either ibudilast or a placebo for 6 weeks. Researchers used brain scans and thinking tests to see if the drug improved brain function an…

This study tested whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) could help veterans with alcohol use disorder stay sober for six months. Forty-nine veterans who were already in treatment received either real or sham …

This pilot study tested whether combining neuromuscular electrical stimulation with daily vitamin D could improve bone health in veterans with chronic spinal cord injury. Six participants underwent 9 months of treatment, with bone changes measured by MRI and DXA scans. The goal w…

This study tested whether a pharmacist-led video visit to the home could improve medication use in older Veterans taking many daily drugs. 304 Veterans with at least 2 chronic conditions and 5 daily medications took part. The goal was to reduce potentially inappropriate medicatio…

This completed phase 3 trial tested whether a lifestyle program (diet and exercise) plus the drug metformin could reverse frailty and sarcopenic obesity in 114 older veterans aged 65-85. Participants followed a weight-loss diet and exercised three times a week, while taking metfo…

This study tested whether probenecid, a medicine usually used for gout, can improve heart function and exercise ability in veterans with heart failure. About 99 veterans with a specific type of heart failure took probenecid twice daily for 180 days. Researchers measured changes i…

This study looked at whether having a live-in support partner helps Veterans lose more weight. 300 Veterans with obesity joined a 72-week weight management program, either with a partner or alone. The goal was to see if teamwork leads to better weight loss and maintenance.

This study looked at 1,424 veterans at high risk for heart problems who had major surgery. It compared two approaches to blood transfusion: a liberal strategy (transfusing when hemoglobin drops below 10) versus a restrictive strategy (transfusing only when hemoglobin drops below …

This study tested a treatment called CPT-SMART that combines PTSD therapy, smoking cessation counseling, medication, and financial incentives to help veterans quit smoking. 120 veteran smokers with PTSD were randomly assigned to either the full program or a control group. The goa…

This study tested a group program called Project Life Force (PLF) against standard individual suicide safety planning for 294 veterans at high risk for suicide. PLF is a 10-session group that teaches coping skills and emotional regulation to strengthen safety plans. Researchers t…

This study tested whether a nurse-led program could help veterans with HIV lower their blood pressure and reduce their risk of heart disease. 305 veterans with HIV and high blood pressure took part. The program used video visits and care coordination to help manage blood pressure…

This completed trial tested a special support program for veterans with both bipolar disorder and substance use problems after they leave the hospital. Half of the 138 participants received the program, while the other half got enhanced safety monitoring. The goal was to see if t…

This study tested whether peer specialists—people who have serious mental illness themselves and are trained to help others—can effectively deliver two types of therapy: Cognitive Behavioral Social Skills Training (CBSST) and Social Skills Training (SST). The goal is to help vete…

This phase 2 trial tested whether combining testosterone therapy with a special type of electrical stimulation (long pulse width) could rebuild leg muscle in 12 people with spinal cord injury whose muscles no longer respond to standard electrical stimulation. Participants receive…

This completed study tested a new approach to reduce suicide behavior in high-risk veterans by combining transcranial magnetic stimulation (TMS) with brief cognitive behavioral therapy (BCBT). Fifty-five veterans who had recently attempted suicide or had strong suicidal thoughts …

This study checked whether 3D-printed nasal swabs work as well as standard swabs for diagnosing COVID-19. About 1,179 people who had COVID-19 symptoms or were recently exposed took part. Researchers compared the new swabs' accuracy and safety, like nosebleed risk, to the usual on…

This study tested whether an electronic self-report screening system (eScreening) helps VA clinics detect depression, PTSD, alcohol problems, and suicide risk more quickly and more often in newly enrolled post-9/11 veterans. Researchers compared screening rates and referral times…

This study tested a simple, portable virtual reality balance test (called VETS) to see if it could help diagnose and track cervical spondylotic myelopathy (CSM), a spinal cord condition common in veterans. Eight participants with CSM and a control group performed balance tasks un…

This large study tested whether giving sodium bicarbonate (a type of fluid) or N-acetylcysteine (a supplement) before and after angiography could prevent serious kidney problems, including death or need for dialysis. Over 5,000 high-risk patients with kidney disease took part. Th…

This study tested a household safety intervention for veterans with elevated suicide risk. The program involved discussions about safely storing firearms and medications, plus providing free safety devices. Researchers enrolled 40 veterans from VA healthcare settings to see if th…

This study tested whether a low-salt, heart-healthy diet (DASH diet) can prevent heart failure in veterans with high blood pressure and metabolic syndrome. 71 veterans received counseling and some also got tailored messages via smartphone or email. The goal was to see if the diet…

This study tested a home-based program to help aging veterans with a history of traumatic brain injury (TBI) improve their thinking skills, such as attention and planning. Twenty-nine veterans aged 65 and older used telehealth technology to complete cognitive exercises from home.…

This completed study tested a sound-based therapy for tinnitus (ringing in the ears) in 108 Veterans. Participants used hearing aids that played either notched noise (sound with the tinnitus frequency removed) or broadband white noise. The goal was to see if notched noise could r…

This study tested whether transcranial magnetic stimulation (TMS) — a non-invasive treatment that uses magnetic fields to stimulate specific brain areas — can improve daily functioning in veterans with PTSD. Researchers compared real TMS to a sham (fake) treatment in 59 veterans.…

This pilot study tested whether a TENS device, placed on the forehead, is safe and practical for treating chronic eye pain in 39 veterans. Participants used the device at home for 6 months. The goal was to see if it reduces pain and to prepare for a larger trial.

This study tested a shorter version of Cognitive Processing Therapy (CPT) for Veterans with PTSD. Many Veterans drop out of the standard 12-session therapy, missing the most helpful parts. The goal was to find which therapy components work best and deliver them in fewer sessions …

This study tested two sleep medications, trazodone and eszopiclone, in 673 veterans with PTSD-related insomnia. The goal was to see if these drugs could reduce insomnia symptoms over 12 weeks. Participants were adults aged 18-75 with military-related PTSD and insomnia. The study …

This study tested custom 3D printed insoles for people with diabetes who are at risk of foot ulcers. Thirty participants wore different types of insoles in a lab to see which ones best reduced pressure on the bottom of the feet. The goal was to improve foot health and mobility.

This study tested a telehealth program (CBT-TS) to help 300 veterans on long-term opioids for chronic pain feel more willing to try non-drug treatments like therapy or exercise. The goal was to reduce pain and reliance on opioids. Results will show if changing beliefs about these…

This study tested a self-help tool called EMBER to see if it helps veterans with obesity engage in VA weight management programs. 470 veterans were randomly assigned to receive EMBER or just a list of programs. Researchers tracked whether participants used weight management servi…

This study tested whether a non-invasive, FDA-approved device called cranial electrical stimulation (CES) can reduce chronic pain in veterans with fibromyalgia. Fifty veterans received either real CES or a placebo treatment for several weeks. Researchers used brain scans and pain…

This study tested whether transcranial magnetic stimulation (TMS) can reduce apathy—a severe lack of motivation—in older veterans with mild cognitive impairment (MCI). About 103 participants received either real or fake TMS over 20 sessions. The goal was to see if TMS could impro…

This completed study looked at whether a once-a-week home-based resistance exercise program could help reduce fatigue in veterans aged 50 and older with Long COVID. The study enrolled 21 participants and measured changes in muscle strength and perceived tiredness. The goal was to…

This study tested a new hybrid pump that creates a vacuum to hold prosthetic limbs in place. Twelve people with leg amputations walked in a lab to see if the pump improved comfort and mobility. The goal was to verify the pump works during walking.

This study looked at whether adding cannabidiol (CBD) to prolonged exposure therapy can reduce PTSD symptoms in military veterans. 136 veterans took either CBD or a placebo alongside their therapy sessions. The goal was to see if CBD helps improve treatment outcomes.

This study tested a weight management program called MOVE!+UP, designed specifically for veterans with PTSD who are overweight or obese. The program adds extra support to standard PTSD care to help overcome barriers like stress and unhealthy habits. Researchers compared it to the…

This study tested whether virtual peer support groups, co-led by a mental health clinician and a trained peer specialist, could help veterans with serious mental illness (like schizophrenia or bipolar with psychosis) feel more socially connected and less distressed. Twenty-eight …

This study looked at whether mindfulness training could help veterans with PTSD who struggle with anger and aggression. 61 veterans took part. The goal was to see if learning to focus on the present moment could help them control angry feelings and reduce aggressive behavior.

This completed study tested whether weekly peer-led social groups could help older veterans struggling with depression and loneliness. Eighteen veterans took part in 16 weeks of group meetings. Researchers measured changes in mood, social support, and loneliness using questionnai…

This study tested whether MitoQ, a dietary supplement, can reduce fatigue in people with multiple sclerosis. 45 participants took either 20 mg, 40 mg, or a placebo daily for 12 weeks. Researchers measured changes in fatigue using a standard survey. The goal is to find a safe, sim…

This study looked at whether a 16-week program of aerobic and resistance exercise could improve physical function and reduce inflammation in HIV-infected veterans aged 50 and older. Thirty-three participants completed the program, and researchers measured changes in heart and mus…

This small study tested whether a special laser treatment can help veterans with leg amputations who have painful scars that make wearing their artificial limb hard. Ten veterans received the laser therapy, and researchers measured changes in pain, scar appearance, walking abilit…

This study tested whether personalized health coaching can improve daily life for Veterans suffering from long-term pain and related symptoms. Researchers enrolled 260 Veterans with chronic multisymptom illness (like fibromyalgia) and measured changes in pain and disability. The …

This study tested a brief form of cognitive behavioral therapy (bCBT) for Veterans with anxiety. 225 Veterans from three VA medical centers received either bCBT (in-person or by video) or usual care. The goal was to see if this short therapy helps reduce anxiety symptoms better t…

This study tested whether an online program for insomnia could help veterans with COPD sleep better and feel better. 13 veterans were randomly assigned to either the online insomnia treatment or online education about sleep. The goal was to see if the treatment improved sleep qua…

This study tested a program called Whole Health STEPS for Veterans with mental health concerns who are not in mental health treatment. The program uses a peer support specialist to help Veterans set and work toward wellness goals, with increasing support as needed. The goal was t…

This small study tested whether shining special LED lights on the head could help veterans with mild traumatic brain injury (TBI) and PTSD think more clearly and feel better. Eight veterans received the noninvasive light treatment, and researchers measured changes in memory, atte…

This study tested a structured cognitive rehabilitation program in 77 veterans and active-duty personnel who had mild traumatic brain injury from blasts. The program aimed to improve thinking skills and quality of life. Participants were aged 21 to 50 and had brief loss of consci…

This study tested a program called EMPOWER for veterans who completed trauma-focused therapy for PTSD and saw improvement. The program includes a workbook and four therapist check-ins over 12 weeks to help veterans manage symptoms on their own. Researchers wanted to see if it cou…

This study tested a special wheelchair that lets people with spinal cord injuries stand up and move around at the same time. The goal was to see if using this chair at home and in the community helps them stand more often and feel more satisfied with their daily activities. Twent…

This study tested whether an internet-based walking program with a pedometer could help veterans with COPD who cannot attend hospital rehab become more active. 146 veterans took part, and their daily step counts were measured. The goal was to see if this approach improves physica…

This study tested whether veterans with chronic low back pain can reduce pain and improve daily function by learning self-administered acupressure. About 300 veterans participated, with half using a tablet app to guide daily acupressure sessions for 6 weeks. The goal was to see i…

This study tested a therapy called Cognitive Behavioral Therapy for Work Success (CBTw) in 294 veterans with serious mental illness (like depression, bipolar disorder, or PTSD) who were unemployed. The goal was to help them find and keep competitive jobs, which can improve their …

This study tested whether prazosin, a drug used for high blood pressure and PTSD nightmares, can reduce headaches in veterans and service members who had a mild traumatic brain injury. 89 participants received either prazosin or a placebo for 12 weeks. Researchers tracked headach…

This study tested whether a type of compassion meditation could help Veterans with chronic pain who also have depression or PTSD. 142 Veterans were randomly assigned to either compassion meditation training or a health education group. The goal was to see if meditation could redu…

This study tested a personalized version of cognitive processing therapy (CF-CPT) for veterans with PTSD. 179 veterans participated to see if tailoring therapy to individual needs improves daily functioning, quality of life, and treatment completion compared to standard therapy. …

This study looked at whether 6 months of supervised exercise training could reduce PTSD symptoms and improve physical health in older veterans with PTSD. 80 veterans took part, with one group doing exercise and another receiving health education. The goal was to see if exercise c…

This study tested whether a brief cognitive behavioral therapy program (six 30-minute sessions) can help veterans with chronic musculoskeletal pain improve their daily functioning and reduce pain-related distress. 184 veterans from primary care clinics took part, with some receiv…

This study tested two online programs designed to help people with multiple sclerosis manage spasticity (muscle tightness) in their legs. Participants attended two video classes that included education and stretching exercises. The goal was to see if these programs could reduce t…

This study tested whether adding oxytocin (a natural hormone) to standard talk therapy helps Veterans with PTSD feel better faster and stay in treatment longer. About 180 Veterans took part, receiving either oxytocin or a placebo alongside therapy sessions. The goal was to see if…

This study tested a behavioral sleep treatment in 36 veterans who have PTSD, insomnia, and sleep apnea. The goal was to see if improving sleep also improves quality of life and daily functioning. Participants attended therapy sessions and reported their sleep and well-being throu…

This study tested a rehabilitation program called Live Long Walk Strong in 151 veterans aged 50 and older who had trouble walking. The program focused on improving strength and balance to help them walk faster. Researchers measured walking speed and other skills to see what parts…

This study tested a new program called Mindful Action for Pain (MAP) in 126 veterans with chronic pain. MAP combines mindfulness meditation with techniques from acceptance and commitment therapy to help people better manage pain and improve daily function. The goal was to see if …

This study tested a special type of talk therapy (cognitive-behavioral therapy, or CBT) delivered over telehealth to help veterans who feel lonely and struggle with substance use. The goal was to see if the program was practical and well-liked by participants. Thirty-six veterans…

This study tested a type of talk therapy called Acceptance and Commitment Therapy (ACT) to help veterans with PTSD improve their social support and relationships. 107 veterans took part, and the therapy focused on helping them feel less isolated and more connected to family and f…

This study looked at whether adding a brief writing therapy called Written Exposure Therapy (WET) to a standard 28-day residential addiction program helps veterans with both PTSD and substance use disorders. Fifty-six veterans were randomly assigned to either standard care alone …

This study tested whether adding a virtual coach (phone support) helps veterans with insomnia use a digital cognitive behavioral therapy program for sleep. 244 veterans were randomly assigned to either the digital program with coaching or with minimal contact. The goal was to see…

This study tested a walking program for veterans with opioid use disorder and chronic pain. Sixty veterans receiving medication for opioid addiction took part. The program included pain education and a step-by-step walking plan using a pedometer. The goal was to see if this appro…

This study tested whether magnetic stimulation to the front of the brain could help older veterans exercise more regularly. Participants used Nintendo Wii-Fit at home and those who struggled to meet exercise goals received either real or fake brain stimulation. The goal was to se…

This study tested a program called PEACE, which includes a one-hour educational session, seven follow-up calls, and a mobile app, to help veterans after they leave a psychiatric hospital. The goal was to see if it could reduce suicidal thoughts compared to standard care alone. Th…

This pilot study tested a text-message intervention to help veterans with social anxiety reduce 'safety behaviors' — things like avoiding eye contact or rehearsing sentences — that get in the way of work and social life. 23 veterans in a work therapy program received text prompts…

This pilot study tested a brief virtual mindfulness program called RECLAIM in 36 veterans who had difficulty adjusting to civilian life after service. The program aimed to reduce depressive symptoms and improve community reintegration. Participants completed questionnaires about …

This study looked at whether two types of talk therapy—Behavioral Therapy and Cognitive Therapy—can help Gulf War Veterans who have trouble sleeping. Fifty veterans took part, and their sleep problems were measured using a standard questionnaire. The goal was to see which therapy…

This study tested a 10-week, at-home cognitive training program for 9 veterans with major depression and a recent suicide attempt. The program aimed to improve decision-making and reduce depression through problem-solving exercises delivered via video calls. Early results suggest…

This study tested an app called EMPOWER-ED that provides education and tools to help veterans reduce or stop taking benzodiazepines (like Xanax or Ativan). Long-term use of these drugs can lead to dependence and other risks. The study enrolled 170 veterans who had been taking ben…

This pilot study tested a behavioral program called Compensatory Cognitive Training (CCT) in 21 veterans with PTSD who still had memory and attention problems despite prior treatment. CCT teaches practical strategies to work around cognitive difficulties, like using reminders and…

This pilot study tested a program called Sleep-SMART for veterans aged 60 and older who have both mild cognitive impairment (MCI) and insomnia. The program combines standard insomnia therapy with memory-support strategies to help participants learn and stick with the treatment. R…

This study tested whether a natural brain chemical called pregnenolone can reduce PTSD symptoms in Iraq and Afghanistan veterans. 96 veterans with PTSD took either pregnenolone or a placebo for 10 weeks and had their symptoms checked regularly. The goal was to see if the suppleme…

This study tested a non-drug approach to help people with phantom limb pain—pain felt in a missing limb. Twenty adults with arm or leg amputations learned to change their brain responses using real-time feedback. The goal was to retrain the brain to reduce pain and improve qualit…

This completed VA study tested two ways to help more veterans with chronic insomnia get brief behavioral treatment (BBTI) in primary care clinics. Over 277,000 veterans were included across four VA medical centers. The study compared training providers alone versus training plus …

This study tested whether orofacial myofunctional therapy (OMT) — simple tongue and throat exercises done during the day — can improve breathing during sleep in people with mild-to-moderate sleep apnea. 209 adults with sleep apnea participated, comparing OMT to a placebo exercise…

This study tested whether taking branched-chain amino acids (BCAAs) can improve sleep and thinking in veterans who have had a mild traumatic brain injury. 160 veterans were randomly assigned to receive different doses of BCAAs or a placebo for 12 weeks. The main goal was to see i…

Nearly 90% of people with Parkinson's disease experience speech problems. This study tested a home-based program combining speech exercises and physical activity, delivered via telemedicine, to improve speech intelligibility. 104 veterans with Parkinson's and speech impairment pa…

This study tested whether neuromuscular electrical stimulation (NMES) can help Veterans with blood cancers maintain physical function and reduce fatigue during stem cell transplant. 46 participants used NMES while in the hospital. The goal was to see if this approach could preven…

This study tested a program called Patient Priorities Care for older veterans with multiple chronic conditions. The program helps patients talk with their doctor about what matters most to them and what they are willing to do. The goal was to see if this approach reduces the burd…

This study tested a therapy called ACT-MI for veterans struggling with moral injury—pain from events that went against their values. 74 warzone veterans took part to see if the therapy was acceptable and practical. The goal was to help them live meaningful lives, not to cure a di…

This study tested a problem-solving program delivered by phone and online for Spanish-speaking caregivers of veterans who had a stroke. The program taught caregivers the COPE model (Creativity, Optimism, Planning, Expert Advice) to help them manage caregiving challenges. Research…

This completed study tested two types of telehealth cognitive behavioral therapy (CBT) in 48 veterans with chronic pain who also felt lonely. One therapy focused on loneliness, the other on coping with pain. Researchers measured changes in loneliness, social interactions, and pai…

This completed study tested whether repetitive transcranial magnetic stimulation (rTMS) can relieve pain, headaches, depression, and other symptoms in 204 veterans with Gulf War Illness. Participants received rTMS, a non-invasive brain stimulation, and reported changes in pain, m…

This study tested a short talk therapy called behavioral activation for veterans with traumatic brain injury (TBI) and depression. About 46 veterans took part, with some receiving the therapy plus usual care and others only usual care. The goal was to see if the therapy was pract…

This completed trial tested a personalized version of Cognitive Rehabilitation and Exposure/Sorting Therapy (CREST) for veterans with hoarding disorder. The therapy was delivered at home via telemedicine and home visits over 24 sessions. Researchers compared it to standard case m…

This study tested a therapy called Impact of Killing (IOK) for veterans with PTSD caused by moral injury—distress from killing or being responsible for a death in war. One hundred veterans received either IOK or a standard PTSD therapy over 10 sessions. The goal was to see if IOK…

This study tested a behavioral program to help older veterans with obstructive sleep apnea use their positive airway pressure (PAP) machine more consistently. About 100 veterans who had stopped using their PAP device worked with a sleep coach over several sessions. The goal was t…

This study tested a phone-based program called Caregiver SOS for employed people caring for Veterans with depression, anxiety, PTSD, or brain injury. The program offers six one-hour sessions over 3-4 months to help manage stress and balance work and caregiving. Researchers measur…

This study tested whether an 8-week mindfulness program (MBSR) could improve quality of life, thinking, and mood in 107 people with Parkinson's disease. Participants were randomly assigned to MBSR or a supportive education group, with sessions held online due to COVID-19. The goa…

This study tested a 10-week group therapy program called START-PTSD for 45 veterans with PTSD who had declined standard trauma-focused treatment. The therapy helps veterans identify and gradually reduce 'safety aids'—behaviors like avoiding certain places or using mental distract…

This study looked at whether Tai Chi or a wellness program could help Gulf War Veterans with chronic pain, fatigue, and mood problems. 114 Veterans took part, with sessions done in person or later by video due to COVID-19. The goal was to see if these gentle mind-body approaches …

This study looked at whether giving doctors information about what matters to older Veterans with chronic pain—like how they store medications and what help they get at home—can improve pain care. Researchers talked to 230 Veterans aged 65 and older, their caregivers, and clinici…

This study tested whether a single therapy (Transdiagnostic Behavior Therapy) works as well as separate, disorder-specific therapies for veterans with PTSD, major depression, or panic disorder. 304 veterans participated, and researchers measured symptoms before, during, and after…

This study tested whether trained peer specialists—Veterans who have faced similar challenges—could help other Veterans at high risk for suicide. Over three months, 17 Veterans received one-on-one support focused on building hope, connection, and a sense of purpose. Researchers m…

This study looked at whether a non-invasive brain training method called neurofeedback can help veterans who have had a mild traumatic brain injury and still suffer from chronic headaches, trouble sleeping, and attention problems. 87 veterans were randomly assigned to receive neu…

This study tested whether specially designed shoes (carbon fiber or spring-loaded) could help people with peripheral artery disease (PAD) walk farther and with less pain. Ten veterans with PAD wore the shoes for three months. Researchers measured changes in walking distance and c…

This study tested a workshop called STEP-Home for 221 post-9/11 Veterans who had trouble reintegrating into civilian life. The workshop taught skills like emotional control, problem solving, and attention to improve daily function and reduce anger. It was designed as a non-stigma…

This study tested whether adding a smartphone app (CBT MobileWork-V) to standard cognitive behavioral therapy helps veterans with depression learn and use therapy skills better. Fifteen OEF/OIF/OND veterans with depression took part. The app was designed to make it easier to prac…

This study tested whether adding the sleep medication eszopiclone (Lunesta) to brief behavioral therapy improves sleep quality and CPAP use in veterans with PTSD and complex insomnia. Fifty-three veterans who had trouble sticking with CPAP therapy for sleep apnea took part. The g…

This study tested a behavioral therapy called Intention Treatment for Anomia in 32 stroke survivors with aphasia (language impairment). The therapy uses a left-hand circular gesture to engage the brain's intention mechanisms and improve word retrieval. Researchers looked at how o…

This study looked at how partnered tango dancing affects brain activity in people with Parkinson's disease. Researchers measured brain signals during leg movements before and after dance training. The goal was to see if dance could improve motor control by changing how brain regi…

This study tested two different 2-month training programs to help veterans with psychosis improve their social interactions and quality of life. 113 veterans took part. The goal was to see which training worked better for everyday social situations.

This study tested special exoskeleton footwear designed to assist walking in people aged 40 and older with peripheral artery disease (PAD). Researchers compared different levels of assistance to see which worked best for comfort and walking performance. The study included 47 part…

This study tested whether repeated doses of ketamine, an FDA-approved anesthetic, could speed up the effects of talk therapy (Prolonged Exposure) for PTSD in 75 veterans. Participants received either ketamine or a placebo alongside therapy. The goal was to see if ketamine could r…

This study tested a one-day life skills workshop for veterans with mild traumatic brain injury, chronic pain, and mental health conditions like PTSD and depression. The workshop taught coping strategies to reduce distress and improve reintegration into civilian life. 176 veterans…

This study tested a phone-based coaching program for veterans with type 2 diabetes who feel stressed or overwhelmed by daily self-care tasks like checking blood sugar and taking insulin. The program gave personalized advice and support to help reduce that stress and improve blood…

This completed study tested whether repetitive transcranial magnetic stimulation (rTMS) can improve memory and thinking in 32 veterans aged 55+ with mild cognitive impairment or dementia. Participants received either real rTMS or a sham (fake) treatment. The main goal was to see …

This study looked at whether the drug tolcapone can help veterans with mild traumatic brain injury improve memory and self-regulation. Fifty-five veterans underwent brain scans and cognitive tests while taking either tolcapone or a placebo. The goal was to see if the drug changes…

This study looked at whether cognitive behavioral therapy (CBT) can help veterans with serious mental illnesses like schizophrenia or bipolar disorder manage chronic pain. 47 veterans took part in a 12-session CBT program designed for chronic pain. The goal was to see if the ther…

This study tested whether applying mild electrical stimulation to the skin over the spinal cord could help regulate blood pressure in veterans with spinal cord injury who have chronically low blood pressure. Ten participants with injuries at or above T6 received stimulation at di…

This study tested whether sitting in front of a bright lightbox for an hour each morning could improve sleep, reduce pain, and boost quality of life in 77 veterans with chronic mild traumatic brain injury (mTBI). Participants used either a lightbox or a negative ion generator (pl…

This study tested whether adding a mild electrical brain stimulation called tDCS to physical therapy could improve walking in people who had a stroke. 44 participants who were at least 6 months post-stroke received either real or fake tDCS while doing gait exercises in a virtual …

This study developed and tested a mobile website called LIMIT to help veterans on long-term opioid therapy safely reduce their opioid use while managing chronic pain. 44 veterans participated, using either the LIMIT app or a pain diary app. The goal was to see if the tool is acce…

This study tested a new program called Adjunctive Family-Cognitive Behavioral Therapy (AF-CBT) for veterans with anxiety disorders. It involved 48 veterans and their family members to see if adding family support to standard therapy was acceptable and helpful. The main goal was t…

This study tested a short, skills-based anxiety treatment for veterans in primary care. 177 veterans with anxiety symptoms were randomly assigned to either the new treatment or usual care. The goal was to see if the brief therapy reduces anxiety and improves daily functioning bet…

This study looks at 65 veterans with PTSD who use cannabis frequently. Researchers want to see if reducing cannabis use improves their daily functioning, mental health, and quality of life. No treatment or drug is given—participants simply report their cannabis use and well-being…

This study tested whether a special sound stimulation (a tone pulsed at 40 times per second) could detect and improve brain function in veterans who were exposed to blasts. Researchers measured brain waves before and after the stimulation in 5 veterans. The goal was to see if thi…

This study looked at whether a 12-week indoor cycling program could improve brain blood flow and function in 37 older veterans (ages 65-80) who did not exercise regularly. Researchers measured brain health before and after the exercise program using MRI scans. The goal was to lea…

This pilot study tested whether health coaching can help veterans who recently left the military adjust to civilian life and reduce suicide risk. Researchers worked with 95 veterans to see if the program was practical and well-received. The goal was to prepare for a larger future…

This study examined how veterans with HIV use My HealtheVet (MHV), an online health portal, to manage their condition. Researchers reviewed medical records and interviewed 123 veterans to understand the impact of MHV on HIV care. The goal was to develop and test an intervention t…

This study tested a new approach called DREAM, where Veterans at risk for sleep apnea could go straight to home sleep testing without an initial in-person clinic visit. Over 6,500 Veterans took part to see if this speeds up diagnosis and treatment. The goal is to make sleep apnea…

This study tested whether a training program called Modeling to Learn (MTL) helps clinic staff improve how many veterans start and finish evidence-based treatments for PTSD, depression, and opioid use disorder. The program uses computer simulations to let staff try out changes to…

This study looked at 37 obese adults to understand why the brain's pleasure response to food is weaker in obesity. Researchers tested if insulin resistance in the brain causes this reduced response and if weight loss can improve it. The goal is to learn why weight loss is hard an…

This study followed 227 veterans with swallowing problems (dysphagia) for 8 weeks to see if measuring throat pressure during swallowing can predict who will improve with therapy. Participants did standard strengthening exercises, and researchers compared their pressure readings, …

This study looked at how complementary health approaches like acupuncture, massage, and yoga affect chronic pain in over 3,600 veterans. Researchers compared the effects of practitioner-delivered therapies alone versus combining them with self-care practices. The goal was to unde…

This study looked at what makes it easier or harder for veteran stroke survivors to do arm and hand exercises at home. Researchers gave surveys about mood, confidence, and sleep, then used a wearable tracker to measure exercise. The goal is to find ways to help people stick with …

This study tested whether simple nudges—like an alert in a doctor's daily task list or an email comparing their prescribing habits to peers—could increase the use of two types of heart failure medications (SGLT2 inhibitors and MRAs) that are proven to save lives but are often und…

This study looked at a telemedicine program called TOP that helps rural veterans with PTSD get care without traveling far. Over 500 veterans took part. The goal was to see which method of rolling out the program worked better to reach more patients and improve PTSD symptoms.

This study tested a program where rural hospitals connect with an infectious disease expert through video calls to improve antibiotic use. The goal was to reduce unnecessary antibiotics and fight drug-resistant infections. Eight VA medical centers participated, and the approach h…

This study looked at whether veterans with traumatic brain injury (TBI) and insomnia can reliably measure their internal body clock at home. Thirty-one veterans wore a wrist device for a week and collected saliva samples to track melatonin levels. The goal was to see if these hom…

This study tested a program called Recovery Bridge, where trained peer specialists (people with lived experience of mental illness) helped veterans leaving a psychiatric hospital connect to outpatient care and community life. Fifteen veterans took part to see if the program was f…

This study tested whether a coaching program for primary care doctors at one VA clinic could improve care for veterans with unhealthy alcohol use. The program aimed to help doctors offer more counseling, medications, and referrals to specialty treatment. Researchers tracked chang…

This study monitored the sleep of 48 veterans with trauma-related nightmares using in-home devices. Researchers aimed to understand how nightmares affect sleep and how they change with cognitive-behavioral therapy. The goal is to improve personalized care for veterans suffering f…

This study looked at whether balance and walking problems in people with Parkinson's disease are caused by changes in the inner ear (vestibular system) rather than just a lack of dopamine in the brain. 60 participants with Parkinson's underwent balance tests and brain scans. The …

This study tested whether taking calcium before exercise can help bones get stronger from workouts. Exercise normally causes a drop in blood calcium, which may limit bone benefits. Researchers gave 18 Veterans calcium or a placebo before exercise to see if it improved bone-buildi…

This study tested a career counseling program called Purposeful Pathways for veterans with psychiatric disorders who were struggling to find or keep jobs. The program involved up to 12 weekly sessions focused on career goals, job searching, and building confidence. Researchers wa…

This study looked at whether sending caring postcards from fellow Veterans can reduce loneliness and improve mental health in older Veterans. Nearly 1,000 Veterans aged 50 and older who had missed VA appointments took part. They received up to 10 postcards and completed surveys t…

This study looked at whether a program called MISSION-CJ can help homeless veterans who have both substance use and mental health problems stay out of trouble with the law. 134 veterans took part, and researchers tracked arrests, substance use, housing, and employment. The goal w…

This completed study tested a simple idea: what if doctors and nurses used hand washing as a cue to practice mindfulness? 343 VA physicians and nurses took part. Some received mindfulness education, group discussions, and an optional app, while others did not. The goal was to see…

This study looked at whether measuring the skin's electrical activity can warn of agitation or aggressive behavior in people with dementia. 21 patients from a dementia unit took part. The goal was to see if a warning signal appears before an outburst, which could help caregivers …

This completed study tested whether training rheumatology clinicians in shared decision making helps veterans with rheumatoid arthritis. About 900 patients from VA clinics took part. The training taught doctors to acknowledge treatment options and involve patients in choices. Res…

This study looked at how negative emotions and stress influence alcohol use in 81 women veterans, including those with PTSD. Researchers measured cravings, heart rate, and drinking patterns, and also examined how these effects change across the menstrual cycle. The goal was to be…

This study looked at how to best help emergency room doctors avoid prescribing potentially harmful medications to older veterans. Researchers compared two methods: giving doctors regular reports on their prescribing habits (passive feedback) versus having them actively discuss an…

This study tested whether a brain wave measurement called mismatch negativity (MMN) can help match veterans with mental illness to the most effective cognitive training program. 100 veterans with conditions like schizophrenia, PTSD, or mood disorders participated. The goal was to…

This study tested a new way to control a robotic arm mounted on a power wheelchair. The arm uses a camera to help guide movements, making tasks like grabbing a drink easier. 21 adults who use power wheelchairs and have trouble with everyday tasks took part. They compared the new …

This study tested a 12-week program where trained peer leaders guided older veterans with mobility issues in group exercise sessions twice a week and healthy eating discussions once a week. The goal was to see if this approach could improve diet quality and physical fitness. Thir…

This completed study surveyed 986 transgender Veterans to learn what helps or hinders them from getting gender-affirming treatments like hormone therapy and mental health care through the VA or community providers. The goal is to identify barriers and facilitators so the VA can i…

This study looked at how often thiamine (vitamin B1) deficiency occurs in hospitalized veterans who do not abuse alcohol. Thiamine deficiency can cause symptoms like fatigue, confusion, and weakness, and may be more common in veterans due to food insecurity and chronic illness. R…

This study looked at 368 patients with severe ankle arthritis who chose surgery. Researchers used surveys, step counts, and motion-capture walking tests to compare how well different surgical procedures improved function and quality of life. The goal was to find out which surgery…

This study tested a new way to assess and train balance using a reaching task. Seven people, including stroke survivors and healthy adults, took part. They stood and pointed at a moving target on a screen, which challenged their balance. The goal was to see if this method could s…

This study looked at 622 veterans with chronic lung disease who had COVID-19. Researchers tracked their health outcomes, recovery, and need for rehabilitation services. The goal was to understand which factors lead to more severe illness and what support patients need after recov…

This study tested a special training platform designed to help older veterans and those with disabilities improve their balance and reduce the risk of falling. Researchers enrolled 62 participants and used reaching tasks at the limits of balance to measure and train stability. Th…

This study tested whether giving PTSD therapy several times a week (massed) helps veterans stay in treatment better than once-a-week sessions. Thirty veterans with PTSD were randomly assigned to either massed or weekly therapy. Researchers measured how many completed treatment an…

This study tested a program called SLAC that helps Veterans who drink heavily and have mental health issues like PTSD or depression get connected to alcohol care. 140 Veterans from VA primary care took part. The goal was to see if the program is practical and liked by Veterans an…

This pilot study tested whether a 'Relational Playbook' combined with leadership coaching could help reduce burnout among cardiology teams at six VA hospitals. Ten staff members participated, using the playbook's resources and interventions to improve their work environment. The …

This pilot study tested an 8-week group program called RBSTE designed to help Veterans of Color build coping skills and empowerment in response to race-based stress. Thirty-seven veterans participated to see if the program is feasible and acceptable. The goal is to gather informa…

This study looked at how to help VA clinics refer more veterans to a suicide prevention telehealth program called SP 2.0. Researchers used coaching and team-based quality improvement methods. Only 4 clinics participated, so the results are very limited and not generalizable.

This study tested a program called Collaborative Decision Skills Training (CDST) to help veterans with serious mental illness (like schizophrenia or major depression with psychosis) work more closely with their doctors in making treatment decisions. The program involved eight wee…

This completed study in 49 veterans with early chronic kidney disease (CKD) tested whether diuretics (water pills) can reduce fluid overload and improve heart health. Researchers measured changes in heart stress markers and symptoms like fatigue after 4 weeks of treatment. The go…

This study tested whether brain wave patterns during sleep can detect PTSD and measure how severe it is. Researchers studied 26 veterans with PTSD using EEG recordings. The goal is to create an objective test that goes beyond questionnaires and doctor assessments.

This completed study looked at 416 veterans with low back pain to find out which physical activities cause short-term pain flares and which help long-term recovery. Participants reported their pain flares and disability over time. The goal is to give better activity advice to peo…

This study tested whether a smartphone app could help veterans with serious mental illnesses like schizophrenia and bipolar disorder track their own symptoms. 87 veterans used the app to monitor their activity, sleep, and social interactions. The goal was to see if this data coul…

This study tested a special prosthetic foot that can twist in a way similar to a natural ankle. Fourteen people with below-knee amputations walked in straight lines and circles while the foot's twisting was adjusted. Researchers measured how much force was put on the leg and aske…

This study looked at how to help more veterans with opioid use disorder get effective medication. Researchers combined six pilot projects across 63 VA sites to find the best ways to increase access to these treatments. The goal was to see if a structured support program for healt…

This study looked at whether it's possible and acceptable to screen for hearing loss in the emergency department (ED). Researchers worked with 133 veterans who had mild hearing trouble to see if using a hearing device helped them communicate with doctors and understand discharge …

This study tested a web-based decision support tool called MyPath for women veterans aged 18-44. The tool helps them think about pregnancy goals and birth control before a VA primary care visit. Half of the 465 participants received a link to the tool before their appointment; th…

This study created and tested a mobile app called VetEd for student veterans dealing with mental health issues like depression, PTSD, or anxiety. The goal was to help them manage academics, mental health, and find resources. Researchers worked with 13 veterans to see if the app w…

This small study tested whether real-time neurofeedback—a technique where people learn to control their own brainwaves—could improve memory-related brain activity in older veterans with mild cognitive impairment. Four veterans aged 60 and older participated. The goal was to see i…

This study looked at how to help busy doctors at VA clinics adopt better treatments for three common issues: reducing risky medications in older adults, using blood thinners more safely, and offering talk therapy for insomnia instead of sleep pills. Researchers compared two diffe…

This study tested a way to give veterans their genetic test results that show a higher risk for heart disease. 112 veterans took part. The goal was to see if sharing this information helps them lower their cholesterol and improve their health. The study focused on developing the …

This completed study tested a centralized Bone Health Service model to improve osteoporosis screening in male veterans aged 65 and older. Over 3,500 veterans from primary care teams took part. The goal was to see if a dedicated bone health team could increase screening rates and …

This study tested whether short video messages could encourage veterans who recently left the military and are thinking about suicide to seek mental health treatment. 355 veterans who were not currently in therapy watched four brief videos on a smartphone app. Researchers then ch…

This study tested whether regular support calls can help veterans who are not ready to quit smoking to eventually stop. Over 500 veterans received either four calls a year (enhanced care) or one call a year (standard care). The goal was to see if more calls led to more quit attem…

This study looked at whether brain signals and thinking skills can predict how well Veterans with cocaine addiction respond to a behavioral therapy called contingency management. In this therapy, patients earn chances to win prizes for providing cocaine-free urine samples. The go…

This study tested whether mild electrical brain stimulation (tDCS) could help 72 older adults (65+) learn and remember a complex walking task, like stepping over obstacles. Participants practiced walking while receiving either real or fake (sham) stimulation. The goal was to see …