Can a Parkinson's drug fix brain injury brain fog?
NCT ID NCT02260570
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study looked at whether the drug tolcapone can help veterans with mild traumatic brain injury improve memory and self-regulation. Fifty-five veterans underwent brain scans and cognitive tests while taking either tolcapone or a placebo. The goal was to see if the drug changes brain activity and boosts memory performance.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Tolcapone (Tasmar), a COMT inhibitor drug
What this could lead to
If it works, this could point toward a medication to help improve memory and impulse control after mild traumatic brain injury.
What could go wrong
This is a very early, small trial (55 people) testing brain scans and cognitive tests, not a proven treatment. Tolcapone may not show clear benefits and has known liver risks.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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VA Northern California Health Care System, Mather, CA
Sacramento, California, 95655, United States