Gout drug shows promise for Veterans' heart failure

NCT ID NCT04551222

Completed Disease control Sponsor: VA Office of Research and Development Source: ClinicalTrials.gov ↗

First seen Nov 10, 2025 · Last updated Apr 30, 2026 · Updated 22 times

Summary

This study tested whether probenecid, a medicine usually used for gout, can help veterans with a type of heart failure called heart failure with reduced ejection fraction (HFrEF). The goal was to see if taking probenecid twice a day for 180 days could improve heart function, exercise ability, and quality of life. The study involved 99 veterans and measured results using heart ultrasounds, exercise tests, and questionnaires.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Cincinnati VA Medical Center, Cincinnati, OH

Cincinnati, Ohio, 45220-2213, United States
Hunter Holmes McGuire VA Medical Center, Richmond, VA

Richmond, Virginia, 23249-0001, United States
Louis Stokes VA Medical Center, Cleveland, OH

Cleveland, Ohio, 44106-1702, United States
Providence VA Medical Center, Providence, RI

Providence, Rhode Island, 02908-4734, United States
VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA

Boston, Massachusetts, 02130-4817, United States

Conditions

Explore the condition pages connected to this study.

HEART FAILURE