Va Office Of Research And Development

This study tests if a computer-based brain training program can help people who survived a stay in the Intensive Care Unit (ICU) recover their thinking and memory skills. Many ICU survivors experience long-term cognitive problems similar to dementia. The study will involve 160 ad…

This study tests whether a personalized letter and proactive phone calls can help veterans with a newly diagnosed lung nodule quit smoking. The program uses the diagnosis as a 'teachable moment' to motivate quitting. Researchers will compare how many veterans use cessation servic…

This study tests a revised version of motivational interviewing, a type of counseling, to see if it can lower suicide attempts and suicidal thoughts in high-risk veterans. About 470 veterans will be randomly assigned to receive this therapy or high-quality usual care. The goal is…

This study tests if a mobile app called Stand Down, with or without extra support from a peer specialist over the phone, can help Veterans who drink heavily cut back. About 234 Veterans who screened positive for hazardous drinking and own a smartphone are taking part. The goal is…

This study tests whether using MRI to guide transcranial magnetic stimulation (TMS) works better than the usual scalp-based method for treating depression. It involves 54 participants, including those with treatment-resistant depression and others with COVID-related distress. The…

This study tests whether a two-step drug treatment can improve bone density in people with long-term spinal cord injury who have bone loss. Participants receive either romosozumab (a bone-building drug) or a placebo for 12 months, followed by denosumab (a bone-strengthening drug)…

This study tests a short therapy called ACT for Life for veterans hospitalized due to suicide risk. The therapy includes 3 to 6 sessions in the hospital and up to 4 follow-up sessions to help veterans build a life worth living and reduce suicide attempts. Researchers will compare…

This study tests whether pentoxifylline, a medicine used since 1984 for leg blood vessel problems, can slow kidney damage and delay death in people with diabetic kidney disease. About 2,376 participants with type-2 diabetes and moderate-to-severe kidney decline are being followed…

This study tests whether a non-invasive brain stimulation technique called rTMS can improve daily functioning in 100 veterans who have both alcohol use disorder and a history of mild traumatic brain injury. Researchers will identify a specific brain target and then stimulate it w…

This study compares two approaches to helping smokers quit: an opt-out method where everyone is automatically referred unless they say no, versus an opt-in method where people must actively sign up. Over 1,300 veterans at VA clinics in New York are taking part. The goal is to see…

This study tests whether levodopa, a drug used for Parkinson's, can slow blood vessel changes in the eyes of people with diabetes. Researchers will give the drug or a placebo to 244 patients with early diabetic retinopathy and measure retinal electrical activity and imaging over …

This study looks at whether game-like features and social rewards can help overweight veterans with high blood pressure become more physically active. About 725 veterans will take part in a 9-month program where they either compete or cooperate to increase their daily steps. The …

This study tests a new mapping method for ventricular tachycardia (VT) ablation that avoids purposely triggering VT. Instead, it uses special software to identify slow-conduction areas during normal heart rhythm. The goal is to see if this approach reduces VT recurrence, death, o…

This study tests whether a team of specialists working together can improve outcomes for frail Veterans having elective surgery. About 35,000 Veterans at three VA hospitals will be randomly assigned to usual care or a multidisciplinary board that reviews each case and makes perso…

This phase 2 study tests pembrolizumab (Keytruda) in 40 men with metastatic castration-resistant prostate cancer that has specific genetic flaws (mismatch repair deficiency or CDK12 inactivation). The goal is to see if the drug can shrink tumors or slow the cancer. Researchers wi…

This study tests whether drinking a protein beverage after leg-strengthening exercises helps stroke survivors rebuild muscle better than exercise alone. About 93 people who had a stroke more than 3 months ago will take part. Researchers will measure changes in thigh muscle size, …

This study looks at whether intermittent fasting (eating only two small meals one day per week) can help overweight veterans maintain weight loss after a 12-week diet and exercise program. Researchers will compare this approach to a standard heart-healthy maintenance plan in 175 …

This study tests a wireless glucose monitoring system (Glucose Telemetry System) in 218 hospitalized veterans with type 2 diabetes who are at high risk for low blood sugar (hypoglycemia). The device sends blood sugar readings from the patient's bedside to a monitor at the nursing…

This study tests whether simvastatin, a drug typically used for cholesterol, can reduce the risk of liver complications in veterans with compensated cirrhosis (scarred but symptom-free liver). About 142 participants will take either simvastatin or a placebo nightly for several ye…

This study tests a program called LOCK, where frontline staff in State Veterans Homes work together in short huddles to identify and reduce fall risks for residents. Over 10,000 Veterans are taking part. The goal is to lower the high rate of falls and improve overall care without…

This study tests a program called TOTAL that uses an educational video and three telemedicine calls to encourage veterans with obesity to start weight loss treatments like the MOVE! program, medications, or surgery. About 440 veterans will take part. The goal is to see if this si…

This study tests whether referring Veterans in early recovery from substance use disorder to work-focused programs (like supported employment) helps them stay sober and function better. About 100 Veterans will be randomly assigned to get the work referral or usual treatment alone…

This study explores whether a simple, non-invasive leg movement test can measure blood vessel health in older adults. Researchers will use ultrasound to track blood flow changes after a passive leg movement, comparing young healthy people and older patients undergoing heart tests…

This study tests a new dry electrode headset that records brain waves (EEG) without needing a specialist to operate it. The goal is to make it easier for Veterans with epilepsy in rural areas to get this key diagnostic test. Researchers will compare the headset's performance to s…

This study tests a special probe that checks blood flow in ulcers left after colon polyp removal. The goal is to see if using this probe to guide treatment can prevent delayed bleeding, especially in patients taking blood thinners or with large polyps. About 180 high-risk adults …

This study looks at whether clopidogrel, a blood thinner, can prevent new silent brain infarctions (small, unnoticed strokes) in people who recently had a stroke or mini-stroke. Researchers will track 134 participants over 24 months using MRI scans and cognitive tests. The goal i…

This large study compares two common colorectal cancer screening methods: colonoscopy and annual fecal immunochemical testing (FIT). Over 50,000 veterans aged 50-75 will be randomly assigned to one of the two screenings and followed for 10 years. The goal is to see which approach…

This study compares a shorter therapy focused on guilt (TrIGR) to a standard PTSD therapy (CPT) in 160 U.S. Veterans. The goal is to see if TrIGR is no less effective at reducing PTSD, depression, and guilt symptoms. Participants are randomly assigned to one of the two treatments…

This study tests whether a non-invasive electrical stimulation device placed on the skin over the spine can help veterans with spinal cord injury improve blood pressure, exercise capacity, and body temperature regulation. Twenty veterans with injuries between the neck and upper b…

This study tests a single cognitive behavioral therapy (CBT) program designed to help veterans who struggle with both anxiety (including PTSD) and hazardous drinking. The goal is to see if treating both issues together improves their daily functioning and reduces symptoms better …

This study looks at whether time-restricted eating (a form of intermittent fasting) is a practical way for veterans with spinal cord injury and obesity to lose weight. Fifteen veterans with paraplegia will try eating all their daily calories within a set window of time for 6 week…

This study tests an 8-week program called Step-CBT that combines physical activity goals with cognitive behavioral therapy for veterans with COPD who also have depression or anxiety. The program is delivered via video calls to make it accessible. Researchers want to see if it is …

This study tests a digital program called OurRelationship for veteran couples experiencing relationship distress. The program includes online modules and coaching sessions over 6-8 weeks. Researchers want to see if it improves relationship satisfaction and reduces stress, anxiety…

This study tests a program called Omnis Salutis for recent veterans with PTSD, depression, anxiety, or substance use disorders. The program teaches veterans to identify their health goals and communicate them to doctors and family. Researchers want to see if it improves social an…

This study tests whether allopurinol, a common gout medication, can improve heart function in African American veterans with resistant hypertension. Participants take allopurinol for 8 weeks, and researchers measure changes in heart function, exercise ability, and quality of life…

This study tests whether a special arm brace that reads muscle signals can help stroke survivors with severe arm weakness recover better during early rehabilitation. Three veterans who had a stroke within the past 6 months will use the device alongside standard therapy. The goal …

This study tests whether nicotinamide riboside (NR), a form of vitamin B3, can improve muscle strength, endurance, and walking speed in older veterans aged 65-85. Participants take NR or a placebo daily for several weeks and undergo exercise tests and muscle biopsies. The goal is…

This study tests a 18-month remote walking program for veterans with lower-limb amputation. The goal is to help them stay active and increase daily steps through coaching, peer support, and self-management. About 95 veterans will participate, and their step counts will be tracked…

This study looks at whether a simple home exercise routine can help veterans who have recently healed from a diabetic foot ulcer. The goal is to improve their ability to walk and move safely without causing the ulcer to come back. The study involves 26 adults aged 50 and older wi…

This study tests whether home-based physical and cognitive exercises, delivered via telemedicine, can reduce chronic pain in people with Parkinson's disease. 166 Veterans will use a stationary bike or smartphone cognitive games from home. The goal is to find an easy, affordable w…

This study tests whether a powered knee exoskeleton called Keeogo can help veterans with knee osteoarthritis walk, climb stairs, and perform daily tasks with less pain compared to standard knee braces. Thirty-two veterans with moderate to severe knee osteoarthritis will try both …

This study tests whether adding a muscle-stimulating device (NMES) to a standard exercise program can strengthen hip muscles and improve balance in older veterans at high risk for falls. About 81 veterans aged 55 and older will take part. The goal is to see if this approach can r…

This study tests whether a gentle electrical stimulation on the skin can improve sleep in veterans with PTSD. The device, similar to a TENS unit, targets two different nerve locations to see which works better. Researchers will measure sleep quality using overnight sleep tests in…

This Phase 3 trial tests whether two easy tests—measuring blood pressure changes when standing and eye reactions to light—can predict which veterans with PTSD will respond to the drug prazosin. The study involves 87 veterans and compares prazosin to a placebo. The goal is to pers…

This study tests whether a progressive exercise program can reduce chronic pain in veteran lung cancer survivors aged 60-80. Nine participants will do treadmill walking, resistance bands, and balance exercises. The goal is to see if exercise can be a safe alternative to opioids f…

This study tests whether a type of talk therapy called Cognitive Behavioral Therapy for Insomnia (CBT-I) can improve sleep and daily functioning in veterans who have both psychosis and insomnia. About 152 veterans are taking part. The goal is to see if better sleep leads to bette…

This study tests whether wearing bright light glasses can improve sleep, thinking, and physical strength in older veterans. The glasses emit a special blue light that may help reset the body's internal clock. Researchers will measure sleep quality, balance, and coordination in 43…

This study tests whether a Dialectical Behavior Therapy (DBT) skills group, added to usual care, helps veterans at high risk for suicide better manage their emotions. About 156 veterans with a history of suicide attempts and current suicidal thoughts will take part. The goal is t…

This study tests whether a 12-week telehealth-supervised exercise program can improve walking ability and quality of life in veterans with peripheral artery disease (PAD). Participants exercise three times a week at a location of their choice. The study measures walking distance,…

This study tests whether partnered dance aerobic exercise can reduce 'OFF-time' (when Parkinson's medication stops working well) and improve thinking skills. Researchers will enroll 82 people with Parkinson's who experience OFF-time. Participants will take dance classes twice a w…

This pilot study tests whether repetitive transcranial magnetic stimulation (rTMS) can reduce alcohol cravings in veterans who also have mild traumatic brain injury or PTSD. Twenty veterans will receive either real or placebo rTMS over 10 sessions in two weeks. The goal is to see…

This study tests whether a stellate ganglion block—a numbing injection in the neck—can quickly reduce PTSD symptoms in veterans. About 410 veterans who still have PTSD after trying standard treatments will receive either the real injection or a sham (fake) one. Researchers will m…

This study tests a device called the Neuromechanical Gait Assist (NMGA) that combines a powered knee brace with muscle stimulation to help people who have difficulty walking after a stroke. Five veterans with leg weakness and a stiff-legged gait will use the device in a lab while…

This study tests a special exercise program for older Veterans with dementia living in VA nursing homes. The program, called PLIÉ, combines gentle movement and mental focus to improve physical function, mood, and social engagement. Staff will be trained to lead the classes, and r…

This study tests whether virtual coaching from fellow veterans can improve quality of life for veterans with multiple chronic conditions. About 298 veterans will be randomly assigned to receive peer health coaching or usual care. The coaching provides education, resources, and su…

This study looks at whether a 20-week program called AgeWISE-AP can help veterans over 60 improve their brain health. The program provides education and personalized planning. Researchers will measure changes in physical activity, memory, mood, sleep, and overall well-being in 13…

This study tests whether a program that educates and supports doctors can help them follow national guidelines for prostate cancer imaging. About 58 VA doctors and staff took part. The goal is to reduce inappropriate scans for low-risk patients and ensure appropriate scans for hi…

This study tests whether a short online training called VA S.A.V.E. helps family and friends of veterans recognize suicide warning signs and connect them to professional help. Over 700 participants who are close to a veteran will take either the training or a general mental healt…

This study looks at whether medical-legal partnerships—where lawyers work closely with healthcare providers—can help veterans with housing problems avoid eviction and homelessness better than standard legal services alone. About 300 veterans will be randomly assigned to either th…

This study aimed to help people with upper limb amputations feel their prosthetic hand as part of their own body. Researchers planned to use nerve stimulation to create touch and position sensations. The study was withdrawn before any participants were enrolled, so no results are…

This study created a large collection of health information and blood samples from 1,275 Veterans who served during the 1990-1991 Gulf War. Researchers will use this data to study long-term health issues. The project also gathered feedback from Veterans to improve how future stud…

This study interviews 14 veterans who served in combat to create a group therapy program for moral injury—the lasting distress from events that violated their values. The goal is to help them reintegrate into civilian life and restore functioning. The research focuses on developi…

This pilot study uses functional MRI to examine brain activity in trauma-exposed veterans with obsessive-compulsive personality traits, known as overcontrol. Overcontrol can strain relationships and increase suicide risk. The study aims to test whether the brain scanning methods …

This study tests whether a job coaching program called Individual Placement and Support (IPS) helps veterans with opioid use disorder find and keep competitive jobs. Researchers will compare IPS to standard vocational rehab in 123 veterans. They also want to see if getting a job …

This study looks at why Veterans with heart failure with preserved ejection fraction (HFpEF) get tired so easily during exercise. Researchers will block nerve signals from leg muscles to see how that affects blood flow and fatigue, both before and after a regular exercise program…

This study aimed to create a self-management program to help veterans with AIS D spinal cord injury improve their well-being. It was designed for veterans who have some movement and sensation but often struggle with emotional and social challenges. However, the study was withdraw…

This study looks at whether a team-based care model can improve how Gulf War Veterans with Gulf War Illness receive treatment. Many veterans are not getting the care they need or are unhappy with their current care. The study involves 281 veterans and measures changes in pain-rel…

This study aimed to understand how physical therapy affects spinal discs in people with low back pain. Researchers planned to use MRI scans to measure changes in the discs before and after 6 weeks of therapy. The goal was to see if these scans could predict which patients would f…

This study looks at how to help VA medical centers offer virtual programs that prevent heart disease, diabetes, and depression in women Veterans. Researchers are testing two different support strategies at 20 VA sites to see which works better. The study does not involve patients…

This study tests whether trained peer specialists can help homeless veterans reduce their use of emergency rooms and hospital stays. Over 24 weeks, 177 veterans will receive 18 coaching sessions focused on whole health. The goal is to see if this support lowers acute care use and…

This study tests a new decision aid tool (OASIS) that helps VA hospitals choose the best strategies to improve screening for liver cancer in patients with cirrhosis. Over 8,000 veterans and clinicians at multiple VA medical centers will participate. The goal is to see if the tool…

This study is testing whether a brain-based biomarker can predict how well stroke survivors recover from spatial neglect—a condition that makes it hard to notice things on one side. Researchers will follow 45 Veterans for 6 months, measuring their daily living skills and neglect …

This study looks at whether a smartphone-based program can help veterans with depression begin and continue mental health treatment. Researchers will analyze medical records to find out who struggles to engage in care, then test an eHealth tool that lets veterans track their mood…

This study tests a new behavioral therapy designed to help veterans with traumatic brain injury (TBI) improve their storytelling and everyday communication. The therapy focuses on both story content and organization. The trial includes 34 veterans and aims to see if the treatment…

This study tests a special education program for veterans with advanced chronic kidney disease. The goal is to help them understand their condition and choose the best type of dialysis, especially home dialysis. About 656 veterans will take part to see if this program improves th…

This study looks at two different methods to help VA clinics adopt a team-based depression care service for veterans living with HIV. The service has been shown to work well and save money, but no VA clinics currently use it. Researchers will compare the two approaches to see whi…

This study aims to find out if changes in blood markers can predict whether exercise helps improve vision. Researchers will compare aerobic exercise to balance training in 14 sedentary adults aged 18 to 89 with vision disorders. The goal is to understand how exercise might protec…

This study was designed to see if a plant-based supplement called PB125 could help veterans with peripheral artery disease (PAD) get more benefit from exercise. The idea was that PB125 might reduce inflammation and oxidative stress, making it easier for patients to walk and exerc…

This study aims to better understand the lung health of veterans who deployed to Southwest Asia and Afghanistan after 9/11. Researchers will measure lung function in 6,200 veterans using breathing tests and track conditions like asthma. The goal is to learn how deployment may aff…

This study is testing whether an EEG (a simple brain wave recording) can predict which veterans with treatment-resistant depression will improve with transcranial magnetic stimulation (TMS). About 266 veterans will get EEG scans before, during, and after TMS treatment. The goal i…

This study compares two methods to help primary care teams deliver better care to Veterans at high risk of hospitalization. One method offers ongoing coaching to individual clinics, while the other uses a learning collaborative where teams share experiences. The goal is to see wh…

This study follows 817 military personnel who served in Iraq to see how war affects mental health, thinking skills, and daily life over time. Participants complete surveys and in-person tests on mood, stress, and memory. The goal is to learn how conditions like PTSD develop and c…

This study looks at whether a structured, time-limited case management program called Critical Time Intervention (CTI) can help homeless veterans stay housed. About 153 veterans across 32 VA sites will take part. The goal is to see if CTI improves housing stability and how much i…

This study tests whether coaching family members through phone calls and a web program can encourage veterans with PTSD to start mental health care. About 122 partners or close family members of veterans will receive either standard coaching or an enhanced version with online tra…

This study was designed to find better ways to manage heart disease in veterans with severe peripheral artery disease (poor leg blood flow) who had leg surgery. It planned to track major heart problems like heart attacks or heart-related death. However, the study was withdrawn be…