Brain wave test may predict TMS success in depressed veterans

NCT ID NCT05008198

Ongoing Knowledge-focused Sponsor: VA Office of Research and Development Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing whether an EEG (a simple brain wave recording) can predict which veterans with treatment-resistant depression will improve with transcranial magnetic stimulation (TMS). About 266 veterans will get EEG scans before, during, and after TMS treatment. The goal is to find a reliable brain signal that tells doctors early on if TMS is working for a particular person.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Transcranial Magnetic Stimulation (TMS)
What this could lead to: If successful, this could help doctors predict who will respond to TMS for depression, saving time and improving treatment choices.
What could go wrong: This is an observational study, not a treatment trial. It aims to find a biomarker, not to prove TMS works. Results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Depression depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEPRESSION

Contacts and locations

Locations

White River Junction VA Medical Center, White River Junction, VT

White River Junction, Vermont, 05001-3833, United States

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