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Withdrawn study sought to unlock back pain mystery

NCT ID NCT04134910

Knowledge-focused Sponsor: VA Office of Research and Development Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled This study
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study aimed to understand how physical therapy affects spinal discs in people with low back pain. Researchers planned to use MRI scans to measure changes in the discs before and after 6 weeks of therapy. The goal was to see if these scans could predict which patients would feel better. However, the study was withdrawn before any participants were enrolled.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Physical therapy
What this could lead to
If successful, this could help identify which back pain patients are most likely to benefit from physical therapy.
What could go wrong
The study was withdrawn before enrolling anyone, so no results are available. It was also small and exploratory, so even if completed, findings might not apply broadly.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Started

Feb 2025

Finished

Feb 2025

Lead sponsor

A government agency

The lead sponsor is a US federal agency other than the NIH.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

30 to 70 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Current activity limiting low back pain * With symptoms of any duration * With or without symptoms extending distal to the buttocks * Medically stable * Candidate for physical therapy Exclusion Criteria: * Documented history of prior spinal surgery * Contraindications to MRI including: * claustrophobia * pregnancy * implanted electronic devices * pacemakers, cochlear implant, insulin pumps, etc * metallic foreign bodies * i.e. shrapnel * documented history of contraindications to gadodiamide (Omniscan) administration: * chronic severe kidney disease * acute kidney injury * impaired elimination of gadolinium based contrast agents * pre-existing renal insufficiency * a prior hypersensitivity reaction to MRI contrast

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Conditions

The condition(s) this trial relates to.

Back Pain intervertebral disk degenerative disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Back pain Intervertebral disc degeneration

Contacts and locations

Locations

  • Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA

    Philadelphia, Pennsylvania, 19104-4551, United States

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