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Veterans study links mild brain injury to dementia clues

NCT ID NCT04124029

Recruiting now Knowledge-focused Sponsor: VA Office of Research and Development Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study is looking at 800 veterans to see if mild traumatic brain injury (concussion) increases the risk of dementia later in life. Researchers will test memory, brain waves, brain scans, and proteins in blood and spinal fluid. The goal is to find early warning signs of diseases like Alzheimer's and chronic traumatic encephalopathy (CTE). No treatment is being tested—this is a fact-finding study.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to
If successful, this could help identify early signs of dementia in people with a history of mild brain injury, leading to better monitoring or future treatments.
What could go wrong
This is an observational study, not a treatment trial. It may not prove that brain injury directly causes dementia, and results may take years to apply.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease Brain Concussion Chronic Traumatic Encephalopathy Cognitive Dysfunction Nerve Degeneration traumatic brain injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MILD COGNITIVE IMPAIRMENT MILD TRAUMATIC BRAIN INJURY MODERATE TRAUMATIC BRAIN INJURY

Contacts and locations

Locations

  • VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA

    RECRUITING

    Boston, Massachusetts, 02130-4817, United States

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