Can a blast of testosterone shrink hard-to-treat prostate cancer?
NCT ID NCT05011383
First seen Jul 23, 2026 · Last updated Jul 24, 2026 · Updated 1 time
Summary
This trial investigates whether high doses of testosterone can shrink tumors in men with metastatic prostate cancer that no longer responds to standard hormone therapy and has mutations in DNA repair genes like ATM or CDK12. Participants receive monthly injections of high-dose testosterone while continuing standard hormone suppression. The study aims to see if this approach triggers a significant drop in PSA levels, a marker of cancer activity.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- high-dose testosterone (bipolar androgen therapy)
- What this could lead to
- If it works, this could offer a new treatment option for men with metastatic prostate cancer that has stopped responding to standard hormone therapy and carries certain gene mutations.
- What could go wrong
- This is a small, early-phase trial, so results may not apply broadly. High-dose testosterone can cause side effects like worsening cancer growth, heart problems, or mood changes.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Atlanta VA Medical and Rehab Center, Decatur, GA
RECRUITINGDecatur, Georgia, 30033, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Durham VA Medical Center, Durham, NC
RECRUITINGDurham, North Carolina, 27705, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Kansas City VA Medical Center, Kansas City, MO
RECRUITINGKansas City, Missouri, 64128, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Memphis VA Medical Center, Memphis, TN
RECRUITINGMemphis, Tennessee, 38104-2127, United States
Contact Phone: •••-•••-••••
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Michael E. DeBakey VA Medical Center, Houston, TX
NOT_YET_RECRUITINGHouston, Texas, 77030, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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North Florida/South Georgia Veterans Health System, Gainesville, FL
RECRUITINGGainesville, Florida, 32608, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Orlando VA Medical Center, Orlando, FL
RECRUITINGOrlando, Florida, 32803, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Ralph H. Johnson VA Medical Center, Charleston, SC
RECRUITINGCharleston, South Carolina, 29401-5799, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Robley Rex VA Medical Center, Louisville, KY
RECRUITINGLouisville, Kentucky, 40206-1433, United States
Contact Phone: •••-•••-••••
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Rocky Mountain Regional VA Medical Center, Aurora, CO
RECRUITINGAurora, Colorado, 80045, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Salisbury W.G. (Bill) Hefner VA Medical Center, Salisbury, NC
RECRUITINGSalisbury, North Carolina, 28144, United States
Contact Phone: •••-•••-••••
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St. Louis VA Medical Center John Cochran Division, St. Louis, MO
RECRUITINGSt Louis, Missouri, 63106, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Tennessee Valley Healthcare System Nashville Campus, Nashville, TN
RECRUITINGNashville, Tennessee, 37212-2637, United States
Contact Phone: •••-•••-••••
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VA Connecticut Healthcare System West Haven Campus, West Haven, CT
RECRUITINGWest Haven, Connecticut, 06516-2770, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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VA Portland Health Care System, Portland, OR
RECRUITINGPortland, Oregon, 97239, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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VA Puget Sound Health Care System Seattle Division, Seattle, WA
RECRUITINGSeattle, Washington, 98108-1532, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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William S. Middleton Memorial Veterans Hospital, Madison, WI
RECRUITINGMadison, Wisconsin, 53705-2254, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a Two-Drug attack stall resistant prostate cancer?
- A PET scan and a blood test may predict which men with advanced prostate cancer will benefit from targeted therapy
- Can a new daily pill slow advanced prostate cancer?
- Radiation plus hormone therapy may slow resistant prostate cancer
- Targeted radiation zaps prostate cancer cells in new trial
- Real-World data may reveal Pluvicto's true impact on advanced prostate cancer survival