Monthly shot vs. daily pill: which works better for opioid addiction?
NCT ID NCT04375033
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compares a once-monthly injectable buprenorphine to the standard daily sublingual tablet (with naloxone) for treating opioid use disorder in 952 veterans. The goal is to see which formulation better keeps people in treatment and helps them stay opioid-free over 48 weeks. Participants will be randomly assigned to one of the two treatments and followed for a year.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
buprenorphine (injectable or sublingual with naloxone)
What this could lead to
If the monthly injection works better, it could offer a more convenient and effective way to help people stay in treatment and avoid relapse.
What could go wrong
This is a Phase 4 study, so the drugs are already approved; however, the injectable may not prove superior, and individual results vary. Risks include injection site reactions and potential for misuse.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Bay Pines VA Healthcare System, Pay Pines, FL
RECRUITINGBay Pines, Florida, 33744-0000, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Email: •••••@•••••
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CERC (VISN1, West Haven, CT)
RECRUITINGWest Haven, Connecticut, 06516-2770, United States
Contact Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Clement J. Zablocki VA Medical Center, Milwaukee, WI
RECRUITINGMilwaukee, Wisconsin, 53295-0001, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Email: •••••@•••••
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Dayton VA Medical Center, Dayton, OH
RECRUITINGDayton, Ohio, 45428, United States
Contact Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hampton VA Medical Center, Hampton, VA
RECRUITINGHampton, Virginia, 23667, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Huntington VA Medical Center, Huntington, WV
NOT_YET_RECRUITINGHuntington, West Virginia, 25704-9300, United States
Contact Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Louis Stokes VA Medical Center, Cleveland, OH
TERMINATEDCleveland, Ohio, 44106, United States
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Minneapolis VA Health Care System, Minneapolis, MN
TERMINATEDMinneapolis, Minnesota, 55417-2309, United States
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North Florida/South Georgia Veterans Health System, Gainesville, FL
RECRUITINGGainesville, Florida, 32608-1135, United States
Contact Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Philadelphia MultiService Center, Philadelphia, PA
RECRUITINGPhiladelphia, Pennsylvania, 19106, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Email: •••••@•••••
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Phoenix VA Health Care System, Phoenix, AZ
RECRUITINGPhoenix, Arizona, 85012, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Providence VA Medical Center, Providence, RI
TERMINATEDProvidence, Rhode Island, 02908-4734, United States
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Salem VA Medical Center, Salem, VA
RECRUITINGSalem, Virginia, 24153-6404, United States
Contact Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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San Francisco VA Medical Center, San Francisco, CA
RECRUITINGSan Francisco, California, 94121-1563, United States
Contact Email: •••••@•••••
Contact Email: •••••@•••••
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Tuscaloosa VA Medical Center, Tuscaloosa, AL
TERMINATEDTuscaloosa, Alabama, 35404-5015, United States
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VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA
TERMINATEDBoston, Massachusetts, 02130, United States
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VA Connecticut Healthcare System West Haven Campus, West Haven, CT
ACTIVE_NOT_RECRUITINGWest Haven, Connecticut, 06516-2770, United States
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VA Long Beach Healthcare System, Long Beach, CA
RECRUITINGLong Beach, California, 90822, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Email: •••••@•••••
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VA North Texas Health Care System Dallas VA Medical Center, Dallas, TX
RECRUITINGDallas, Texas, 75216-7167, United States
Contact Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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VA Palo Alto Health Care System, Palo Alto, CA
RECRUITINGPalo Alto, California, 94304-1207, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Email: •••••@•••••
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VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA
TERMINATEDPittsburgh, Pennsylvania, 15240, United States
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VA Puget Sound Health Care System Seattle Division, Seattle, WA
RECRUITINGSeattle, Washington, 98108-1532, United States
Contact Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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VA Salt Lake City Health Care System, Salt Lake City, UT
RECRUITINGSalt Lake City, Utah, 84148-0001, United States
Contact Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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White River Junction VA Medical Center, White River Junction, VT
TERMINATEDWhite River Junction, Vermont, 05001-3833, United States
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Wilmington VA Medical Center, Wilmington, DE
RECRUITINGWilmington, Delaware, 19805-4917, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Email: •••••@•••••