New combo aims to outsmart relapsed lung cancer
NCT ID NCT06681220
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests a new combination of two oral drugs, Stenoparib and Temozolomide, in people whose small cell lung cancer has returned after initial treatment. The trial uses a blood test (biomarker) to see who might benefit most from the combo, comparing it to the standard drug Lurbinectedin. About 166 participants will take part to first find the safest dose, then see if the combo improves outcomes.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Stenoparib and Temozolomide combination
What this could lead to
If successful, this could offer a new, biomarker-guided treatment option for people with relapsed small cell lung cancer, potentially improving how long they live without their cancer growing.
What could go wrong
This is an early-phase trial (Phase 1/2) with a small number of participants, so the benefits are uncertain. The drug combination may cause side effects or may not work better than the current standard treatment.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA
RECRUITINGPhiladelphia, Pennsylvania, 19104-4551, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Jesse Brown VA Medical Center, Chicago, IL
NOT_YET_RECRUITINGChicago, Illinois, 60612, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Michael E. DeBakey VA Medical Center, Houston, TX
RECRUITINGHouston, Texas, 77030-4211, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Minneapolis VA Health Care System, Minneapolis, MN
NOT_YET_RECRUITINGMinneapolis, Minnesota, 55417-2309, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Omaha VA Nebraska-Western Iowa Health Care System, Omaha, NE
NOT_YET_RECRUITINGOmaha, Nebraska, 68105-1850, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Richard L. Roudebush VA Medical Center, Indianapolis, IN
RECRUITINGIndianapolis, Indiana, 46202-2884, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Robley Rex VA Medical Center, Louisville, KY
NOT_YET_RECRUITINGLouisville, Kentucky, 40206-1433, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Salisbury W.G. (Bill) Hefner VA Medical Center, Salisbury, NC
RECRUITINGSalisbury, North Carolina, 28144, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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VA Ann Arbor Healthcare System, Ann Arbor, MI
NOT_YET_RECRUITINGAnn Arbor, Michigan, 48105-2303, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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VA Palo Alto Health Care System, Palo Alto, CA
RECRUITINGPalo Alto, California, 94304-1207, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA
RECRUITINGPittsburgh, Pennsylvania, 15240, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••