Brain blood flow secrets revealed? new trial tests how we react to low flow

NCT ID NCT06629090

Recruiting now Knowledge-focused Sponsor: University of Wisconsin, Madison Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 07, 2026 · Updated 3 times

Summary

This study looks at how the brain's blood vessels respond when blood flow drops suddenly. Healthy adults aged 20-40 will undergo MRI scans while doing breathing exercises and a simulated postural change. Some will receive a single dose of prazosin, a blood pressure drug, to see how it affects brain blood flow. The goal is to better understand the brain's natural defenses against low blood flow.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: prazosin
What this could lead to: If successful, this could help researchers understand how the brain regulates blood flow during low-flow states, potentially guiding future treatments for conditions like fainting or stroke.
What could go wrong: This is a small, early-phase study in healthy volunteers, not patients. The results may not apply to real-world conditions or lead directly to treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CEREBROVASCULAR CIRCULATION MAGNETIC RESONANCE IMAGING

Contacts and locations

Locations

University of Wisconsin
RECRUITING

Madison, Wisconsin, 53705, United States

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