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Could a gentle zap to the forehead protect the brain after injury?

NCT ID NCT07044596

Recruiting now Knowledge-focused Sponsor: University of Wisconsin, Madison Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether mild electrical stimulation of a nerve in the forehead can improve blood flow and waste clearance in the brain. Researchers will measure changes in brain fluid flow using MRI and light-based imaging in 55 healthy adults and people with mild traumatic brain injury. The goal is to see if this non-invasive approach could eventually help slow cognitive decline.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
V1 stimulation electrodes (mild electrical stimulation of the trigeminal nerve)
What this could lead to
If it works, this could point toward a non-invasive way to help clear waste from the brain and potentially slow cognitive decline after brain injury.
What could go wrong
This is a small, early-stage study (55 participants) focused on measuring blood flow and fluid changes, not on clinical outcomes. It may not lead to a proven treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Brain Concussion Post-Concussion Syndrome traumatic brain injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MILD TRAUMATIC BRAIN INJURY POST-CONCUSSION SYNDROME

Contacts and locations

Locations

  • University of Wisconsin - Madison

    RECRUITING

    Madison, Wisconsin, 53705, United States

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