New stem cell filtering method could make transplants safer for kids
NCT ID NCT04806347
First seen Jun 27, 2026 · Last updated Jul 24, 2026 · Updated 4 times
Summary
This early-phase study tests a new way to do stem cell transplants for children and young adults with blood diseases. Doctors will take stem cells from a family member or closely matched unrelated donor, filter out certain immune cells using a special machine, and then give them to the patient. The goal is to see if this method helps the new stem cells grow without causing severe graft-versus-host disease, a common and dangerous complication.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- TCRαβ+ and CD19+ depleted hematopoietic stem cells
- What this could lead to
- If successful, this approach could offer a safer stem cell transplant option for children with blood diseases who lack a perfect donor match, reducing severe side effects.
- What could go wrong
- This is a very early (Phase 1) and small (12 participants) study, so results may not apply broadly. The procedure carries risks like graft failure, severe GVHD, or infection.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
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Study contacts
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Contact
Email: •••••@•••••
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