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Brain anatomy may influence blood flow regulation

NCT ID NCT05396287

Knowledge-focused Sponsor: University of Wisconsin, Madison Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 07, 2026 · Last updated Jul 08, 2026 · Updated 1 time

Summary

This study investigates how natural variations in brain anatomy affect the brain's ability to regulate blood flow. Healthy adults undergo an MRI while performing two breathing tests—one with increased carbon dioxide and one with low oxygen—to measure changes in brain blood flow. The goal is to compare responses between people with and without a specific anatomical variation (VAH). This research may help scientists better understand individual differences in brain blood flow regulation.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could improve understanding of how brain anatomy affects blood flow regulation, potentially guiding future research on brain health.
What could go wrong
This is an observational study with no treatment, so it will not directly improve health. Results may not apply to people with medical conditions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 80 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2022

Expected to finish

May 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Subjects for this study, will include healthy adults enrolled in the Wisconsin Alzheimer's Disease Research Clinical Core. Both men and women are eligible to participate in this study.

Ages

55 to 69 years

Sex

Anyone

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * BMI ≤38.5 kg/m2 * Nonsmoker * Female subjects: postmenopausal * Currently enrolled in the Wisconsin Alzheimer's Disease Research Clinical Core Exclusion Criteria: * Diagnosis of mild cognitive impairment or Alzheimer's disease * Uncontrolled hypertension * History or evidence of hepatic disease, hematological disease, or peripheral vascular disease * Severe kidney injury requiring hemodialysis * Cardiovascular disease including: severe congestive heart failure, coronary artery disease, ischemic heart disease (stents, coronary artery bypass grafts) and tachycardia * History of clinically significant ischemic or hemorrhagic stroke, or significant cerebrovascular disease * History of HIV/AIDS * Severe untreated obstructive sleep apnea * History of diabetes with HbA1c greater than 9.5% * Major neurologic disorders other than dementia (e.g., multiple sclerosis, amyotrophic lateral sclerosis, brain surgery, etc.) * Current or recent (\<1 year) major psychiatric condition (Axis I) or addictive disorders * Contraindications to MRI

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Brain blood flow Healthy

Contacts and locations

Locations

  • University of Wisconsin-Madison

    Madison, Wisconsin, 53706, United States

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