HEALTHY ADULT PARTICIPANTS

This early-stage trial tests a new drug called MTX-439, an antibody that blocks a protein linked to kidney scarring. It will be given to healthy volunteers and people with diabetic kidney disease to check for safety and how the body processes it. The study is small (88 participan…

This study tests CPV-104, a new medicine designed to calm an overactive immune system part that attacks the kidneys in C3 glomerulopathy (C3G), a rare kidney disorder. It is the first time CPV-104 is given to people. The trial includes 39 participants: healthy volunteers receivin…

This study tests a nasal spray called RIG-101 in healthy people and those with asthma. First, it checks safety and tolerability. Then, asthma participants receive the spray daily and are exposed to a cold virus to see if it prevents asthma worsening. The trial is recruiting 82 ad…

This study is testing whether a natural oil pulling mouthwash (GuruNanda) can whiten teeth better than a standard whitening mouthwash or a placebo. 120 healthy adults will use one of three rinses nightly for a period. Researchers will measure tooth shade and stain levels using sp…

This study tests whether a mild electrical pulse to the ear (called taVNS) can reduce nausea in 35 healthy adults. Nausea is triggered by a fatty drink given through a tube. Half the group gets the real stimulation, half gets a fake version. Researchers measure nausea and other s…

This study tests a smartphone-based program designed to improve REM sleep quality. Researchers want to see if better REM sleep can help healthy adults feel less stressed, regulate emotions more easily, and enjoy a higher quality of life. The study will involve 360 participants an…

This early-stage study is testing a new drug called ADX-626 in 44 healthy adults to see if it is safe and how the body processes it. Participants will receive either the drug or a placebo (saline). The study does not aim to treat any disease, but to gather important safety inform…

This early study is testing whether mild electrical or ultrasound stimulation on the skin can change brain activity in healthy adults. Researchers will measure brain waves using a special EEG cap during active and fake (sham) stimulation. The goal is to find reliable markers of b…

This study tests whether a mild, non-invasive electrical stimulation called TI-TES can temporarily change brain activity during sleep, specifically sleep spindles. Up to 24 healthy adults will each have three overnight visits. Researchers will compare brain activity during real s…

This early-stage trial is testing the safety and tolerability of a new drug called NHL907 in 64 healthy adults aged 18 to 60. Participants receive multiple oral doses of NHL907 or a placebo. The study measures side effects and how the drug moves through the body, but does not aim…

This study tests whether a mild, painless electrical stimulation on the ear can change how the stomach and upper gut move in healthy adults. Twelve volunteers will receive both real and fake stimulation in a random order during an 8-hour session. The goal is to see if this simple…

This early-stage trial in 180 healthy adults compares two ways of giving the drug navenibart: by autoinjector or by vial and syringe. The goal is to see if both methods lead to similar drug levels in the blood and have similar safety. Participants receive one dose and are monitor…

This study looks at how eating low or high amounts of fiber changes the compounds in your breath and gut. Twenty healthy adults will try both a low-fiber (10g/day) and a high-fiber (40g/day) diet for three days each, with a three-week break in between. Researchers will measure br…

This study looks at how healthy adults absorb, process, and eliminate certain natural compounds (polyphenols) from a supplement made from artichoke by-products. Sixteen volunteers will follow a low-polyphenol diet and provide blood and urine samples over 48 hours. The goal is to …

This study looks at how stopping smoking for six weeks affects the body's chemistry and gut bacteria in people being treated for substance use disorders. Researchers will compare 100 participants who quit smoking with 50 healthy controls, using blood and stool samples along with …

This study tests a new type of brain stimulation called transcranial Temporal Interference Stimulation (tTIS) in 30 healthy adults. The goal is to understand how it works by applying it over the motor cortex and measuring brain activity. This research could help improve future tr…

This study aims to see how Jägerbombs (a mix of energy drink and alcohol) affect young adults differently than drinking alcohol alone during a binge-drinking session. Researchers will measure reaction time, coordination, vision, stress hormones, and hangover symptoms in 24 health…

This early-stage trial is testing whether a new drug called BV100 changes how the body processes the antibiotic polymyxin B. Sixteen healthy adults will receive polymyxin B alone and then again with BV100 to compare drug levels. The goal is not to treat disease but to gather safe…

This study explores whether a safe, non-invasive brain stimulation technique called transcranial random noise stimulation can temporarily improve language performance. Ninety healthy adults (ages 18-35 or 60-90) will receive both active and placebo stimulation in separate session…

This study is testing a robot called Regen that helps physical therapists guide patients' leg movements during walking. Researchers want to see if the robot is safe, easy to use, and can copy a therapist's movements. Ten healthy adults aged 18 to 50 will walk on a treadmill while…

This study looks at whether breathing slowly (6 breaths per minute) lowers stress more than breathing at a normal pace or just resting. Healthy adults will practice a breathing method, then take a stress test involving cold water and math. Researchers will measure heart rate, str…

This study tests a single dose of ALXN2230 in 48 healthy adults to see if it is safe and how the body processes it. Participants receive either the drug or a placebo by injection. The goal is to check for side effects and measure drug levels in the blood.

This study is testing a new radioactive tracer called [18F]GATT-44 to see how well it can image GABA transporters in the brain using PET scans. The goal is to understand how the tracer moves through the body and binds to brain cells, and to measure the radiation exposure. About 3…

This study looks at how eating kimchi, a fermented cabbage dish, affects the gut microbiome and overall health in healthy adults. Sixty participants will eat either kimchi or non-fermented cabbage daily for three weeks. Researchers will measure changes in gut bacteria, digestion-…

This study aims to translate and test a tool that measures how much parents and future parents know about toxic chemicals in the environment and how those chemicals might affect children's development. Researchers will ask 204 adults to fill out surveys to see if the Turkish vers…

This early-stage study looks at how three common drugs (itraconazole, rifampin, and midazolam) affect the levels of an experimental drug called SIM0270 in the body. About 60 healthy Chinese adults aged 18 to 55 will take part. The goal is to gather safety and drug interaction inf…