HEALTHY ADULT PARTICIPANTS

This study tested a new drug called BGB-45035 for the first time in humans. It looked at safety in healthy volunteers and then in people with autoimmune skin diseases like atopic dermatitis (eczema) and prurigo nodularis (a condition causing intensely itchy bumps). The goal was t…

This study looked at whether adding probiotics or antibiotics to standard non-surgical gum disease treatment helps improve gum health. Sixty adults with severe periodontitis took part. The goal was to see if probiotics could be a safer alternative to antibiotics, which can cause …

This trial evaluates how easy and effective the Intelligent Fingerprinting Drug Screening System is to use in a clinic. It involves 45 healthy adults: 15 operators who are trained to use the system and 30 donors who provide samples. The study focuses on whether operators can succ…

This study tested whether using a laser instead of a scalpel for gum surgery reduces pain and discomfort. 36 healthy adults with missing teeth and shrunken gums took part. The results showed that laser-treated areas caused significantly less pain and discomfort than the tradition…

This early-stage trial is testing an experimental drug called ACC017 in healthy adults to see if it is safe and how the body processes it. Researchers are giving different single doses to small groups of volunteers, some receiving a placebo, to find a recommended dose for future …

This early-stage study tests the safety of a new drug called EDG-7500 in 24 healthy adults, both Japanese and Caucasian. Participants receive single or multiple doses, and researchers measure how the drug moves through the body. No treatment benefit is expected; the goal is to ga…

This pilot study investigates whether a brief bout of respiratory muscle training can alter the brain's control over tongue muscles in healthy adults. Twenty participants will perform breathing exercises using devices that resist inhalation or exhalation, and researchers will mea…

This study investigates how the artificial sweetener acesulfame potassium (Ace-K) is processed and eliminated after drinking 500 mL of Coca-Cola Zero Sugar. Ten healthy adults provide urine samples before and repeatedly over 24 hours after drinking either Coke Zero or still water…

This study tests whether personalized digital coaching helps people stick to brain-healthy habits like exercise, diet, and sleep. 120 adults at risk for cognitive decline will be assigned to generic education, a digital platform, or the platform plus health coaching. The goal is …

This pilot study tests whether a rusk (a type of crisp bread) enriched with arabinoxylan fiber can improve how the body handles sugar after a meal. Ten healthy adults will eat either the fiber-enriched rusk or a standard rusk, and researchers will measure changes in blood glucose…

This study compares a new generic selegiline skin patch to the brand-name EMSAM® patch in 92 healthy adults. Researchers measure how much drug enters the bloodstream and how well the patch sticks to the skin over 24 hours. The goal is to see if the generic version works just as w…

This study looks at whether frying foods in a blend of palm and canola oils with added surfactants and green tea extract can reduce the rise in blood fats (triglycerides) that happens after eating. Healthy adults eat fried foods made with either the special oil blend or regular p…

This study looked at how a device called Firefly® affects blood flow and oxygen levels in the arm muscles of 10 healthy adults. The device uses mild electrical pulses to stimulate nerves and muscles. Researchers measured changes in blood flow and oxygen while the device was on an…

This study tested whether a mild electrical stimulation on the ear (taVNS) can reduce stress in 60 healthy adults. Participants received either real or fake stimulation before a stressful task. The main goal was to see if it lowered cortisol levels in saliva. Results could help d…

This completed pilot study looked at whether a specific osteopathic technique called lymphatic pump can change immune markers in healthy adults. Thirty-three volunteers received either the active technique or a light touch sham, with blood drawn before and after to measure white …

This study looked at how 12 healthy adults coped emotionally during an 80-kilometer ultra-endurance race. Researchers measured defense mechanisms, emotional intensity, and fatigue before, during, and after the event. The goal was to understand how psychological strategies affect …

This study looked at how 8 healthy adults coped emotionally during a 120-km ultra-endurance race. Researchers measured defense mechanisms and emotional regulation before and during the race, along with physical and mental fatigue. The goal was to understand how these psychologica…

This study looked at whether a mobile app called Stressometer can help measure stress in healthy university students. Thirty students used the app four times a day for two weeks to rate their stress. Researchers then compared those ratings to results from standard stress, anxiety…

This early-stage study tested an experimental oral drug called ARN-75039, being developed to treat Lassa fever, a serious viral illness. The trial involved 94 healthy adults aged 18 to 55 who received either the drug or a placebo to check for side effects and how the drug moves t…

This early-stage trial tested the safety of a new drug called PORT-77 in 156 healthy adults. Participants received either the drug or a placebo, and researchers monitored side effects and how the drug moves through the body. The goal was to gather initial safety information, not …

This study looked at whether a roller massage (like using a foam roller) can temporarily lower blood pressure in healthy young adults. Researchers measured changes in tissue hardness and blood pressure after a short massage session. The goal was to understand how massage might af…

This study looked at how a long, whole-body cold water bath changes stress hormones, immune cells, and other body chemicals in healthy young adults. Researchers measured these markers over two days in 41 participants. The goal was to understand the body's response to cold, not to…

This study looked at whether eating three apples daily for three days changes the activity of gut bacteria in healthy adults. Fifteen volunteers provided stool samples before and after the apple-eating period. Scientists analyzed the samples to see if short-term fruit fiber intak…

This early-stage trial tested the safety and tolerability of a new drug called TBD11 in 124 healthy adults. Participants received either single or multiple doses of TBD11 or a placebo, and some took it with food to see if that changed how the drug behaves. The study is complete a…

This study looked at whether taking two smaller capsules of centanafadine (a potential ADHD medication) works the same as taking one larger capsule. 44 healthy adults took both versions at different times to compare how the drug enters the blood. The goal was to confirm the doses…

This study tested whether wearing minimalist (barefoot-style) shoes for 4 hours a day over 5 months changes foot muscles, stability, and pressure in healthy adults. 90 participants were split into minimalist shoe and regular shoe groups. The goal was to see medium-term effects on…

This study used a tiny radioactive tag to track how the experimental drug PF-07248144 moves through the body. Eight healthy adults took the drug by mouth and later by IV to measure absorption and elimination. The goal was to understand the drug's behavior, not to treat any diseas…

This study in 28 healthy adults checks whether the experimental cancer drug vorasidenib changes how the body processes several common medications, including pain relievers, sedatives, and cholesterol drugs. Participants take the other drugs alone and then again with vorasidenib t…

This early-phase trial tested the safety and tolerability of a new drug called TBD09 in 36 healthy adults. Participants took either TBD09 or a placebo daily for 84 days. The goal was to check for side effects and how the drug moves through the body, not to treat any disease.