Scientists track coke zero sweetener through the body in 24-Hour urine study

NCT ID NCT07694401

Completed Knowledge-focused Sponsor: Czech University of Life Sciences Prague Source: ClinicalTrials.gov ↗

First seen Jul 10, 2026 · Last updated Jul 24, 2026 · Updated 2 times

Summary

This study investigates how the artificial sweetener acesulfame potassium (Ace-K) is processed and eliminated after drinking 500 mL of Coca-Cola Zero Sugar. Ten healthy adults provide urine samples before and repeatedly over 24 hours after drinking either Coke Zero or still water, with a month between each test. Researchers use advanced spectroscopy to measure Ace-K levels and other metabolic changes. The goal is to understand the body's short-term handling of this common sweetener.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Coca-Cola Zero Sugar (containing acesulfame potassium)
What this could lead to: If it works, this could help scientists understand how artificial sweeteners are processed by the body and whether they cause any short-term metabolic changes.
What could go wrong: This is a very small study (10 people) looking only at urine markers over 24 hours. It cannot tell us about long-term health effects or apply to people with health conditions.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEALTHY ADULT PARTICIPANTS

Contacts and locations

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Locations

Czech University of Life Sciences Prague

Suchdol, Prague, 16500, Czechia

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