New PET tracer aims to spot Parkinson's in the brain

NCT ID NCT07640542

Recruiting now Diagnosis Sponsor: MODAG GmbH Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 1 time

Summary

This early-phase trial tests a new radioactive tracer called [11C]MODAG-005 that binds to abnormal protein clumps in the brain linked to Parkinson's disease and multiple system atrophy. Nine participants (patients with Parkinson's, MSA, and healthy volunteers) will receive the tracer and undergo PET scans to see if it safely highlights these protein deposits. The goal is to improve diagnosis and distinguish between these similar conditions.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: [11C]MODAG-005 (a radioactive tracer for PET scans)
What this could lead to: If successful, this could lead to a new way to diagnose Parkinson's disease and multiple system atrophy more accurately using brain scans.
What could go wrong: This is a very early, small pilot study with only 9 participants. The tracer may not reliably distinguish between diseases or may have safety issues.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

multiple system atrophy Nerve Degeneration Parkinson disease Shy-Drager Syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEALTHY ADULT PARTICIPANTS MSA - MULTIPLE SYSTEM ATROPHY PARKINSON DISEASE (PD)

Contacts and locations

Locations

Radiologische Klinik, Universitätsklinikum Tübingen, Abt. Nuklearmedizin & Klinische Molekulare Bildgebung
RECRUITING

Tübingen, Baden-Wurttemberg, Germany

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