PARKINSON DISEASE (PD)

This study tests a new type of deep brain stimulation (DBS) that automatically adjusts its settings based on real-time brain signals, unlike standard DBS which uses fixed stimulation. Sixty people with Parkinson's disease will have a special neurostimulator implanted and then exp…

This early-stage trial tests whether transplanting 10 million special nerve cells made from stem cells into the brain is safe for people with moderate Parkinson's disease. Ten participants will receive the cells in a single surgery. The main goal is to check for side effects and …

This study tests whether D-serine, a dietary supplement, can slow the progression of Parkinson's disease. One hundred people with early-stage Parkinson's will receive either D-serine or a placebo for 58 weeks. Researchers will measure changes in symptoms and brain scans to see if…

This study tests whether a daily supplement containing a specific probiotic, tryptophan, and branched-chain amino acids can slow the progression of early-stage Parkinson's disease. Researchers will recruit 120 participants and randomly assign them to receive either the supplement…

This study tests a single injection of lab-grown nerve cells made from stem cells to treat early-onset Parkinson's disease. The cells are designed to replace the dopamine-producing neurons that are lost in Parkinson's. The trial has two phases: first, a small safety test in 6-12 …

This early-stage trial tests a new treatment called PDR-001 for Parkinson's disease. It uses a harmless virus to deliver a peptide into a specific brain area, aiming to clear toxic protein clumps that cause the disease. The study will enroll 12 people with early Parkinson's to ch…

This study tests a new radioactive tracer called 18F-mFBG to see if it can detect nerve damage in the heart caused by Lewy body diseases like Parkinson's and Lewy body dementia. About 20 adults will get a PET scan after an injection of the tracer. The goal is to see if the scan c…

This study is testing whether a blood test can detect Parkinson's disease early, before symptoms become severe. Researchers will measure specific proteins (α-synuclein) in tiny particles from nerve cells in the blood of 600 people with Parkinson's and 600 healthy controls. The go…

This study tests whether dual-task training—doing cognitive tasks like counting backwards while performing hand exercises—can improve upper limb function and muscle thickness in people with Parkinson's disease. 38 participants will be assigned to either the training group or rout…

This study tests whether mild electrical stimulation of the ear, combined with physical and speech therapy, can improve symptoms like voice problems, swallowing, and balance in people with Parkinson's disease. 46 participants will receive either active or sham stimulation during …

This study tests two extra therapies added to standard exercise rehab for people with Parkinson's disease: robot-assisted walking training and electrical stimulation of the thigh muscle. Forty participants will be randomly assigned to one of the two groups and undergo treatment f…

This study aims to find out which type of exercise helps people with Parkinson's disease the most. Researchers will compare different supervised exercise programs to see how they affect movement, balance, endurance, and quality of life. The study involves 45 adults with mild to m…

This study explores whether people with Parkinson's disease can improve their quality of life, walking speed, and mobility by managing their own exercise plans at home using telerehabilitation. Researchers will compare self-managed exercise to supervised programs in 30 participan…

This study tests whether a 12-week exercise program that combines balance, treadmill walking with mental tasks, and leg strengthening can improve gait and balance in people with moderate-to-advanced Parkinson's disease. 48 participants will be randomly assigned to either the exer…

This study tests whether adding a mild, non-invasive brain stimulation (tDCS) to a supervised Nordic walking program improves walking speed and balance in people with Parkinson's disease. Forty participants will be randomly assigned to receive either real or fake tDCS during 12 w…

This early study tests whether a leg sleeve called the Cionic Neural Sleeve is safe and easy for people with Parkinson's to use at home. Ten volunteers with walking problems will try the device, which uses mild electrical pulses to help muscles move. The main goal is to see if pe…

This study explores whether a 6-week training program in empathy and self-compassion can improve the quality of life for people with Parkinson's disease and their caregivers. Participants will practice mindfulness, writing, and poetry exercises, and fill out questionnaires before…

This study is testing whether a specially designed amino acid supplement can improve nutrition, reduce oxidative stress, and boost physical and mental health in people with Parkinson's disease. Thirty adults aged 60-80 with Parkinson's will take either the supplement or a placebo…

This early study tests whether gentle ultrasound waves aimed at a deep brain area can safely reduce hand tremors. It will include 12 people with Parkinson's, essential tremor, or dystonic tremor who haven't gotten enough relief from medication. The main goal is to check safety, b…

This study is testing whether special smart socks (DANU) can accurately measure walking and balance in people with Parkinson's disease. Researchers will compare the socks' readings to standard lab equipment. The goal is to see if these socks can help predict falls. The study invo…

This observational study tests whether DANU Smart Socks can accurately measure walking and balance in people with Parkinson's disease. Researchers will compare data from 60 participants (30 with Parkinson's and 30 healthy older adults) during a single lab visit. The goal is to se…

This study uses ultrasound to measure the thickness of abdominal breathing muscles in people with Parkinson's disease. Researchers want to see if muscle thickness is linked to disease severity and how strong a person's exhale is. The study will include 36 Parkinson's patients at …

This study is looking at hearing in people with early-stage Alzheimer's or Parkinson's disease, compared to healthy volunteers. Researchers will use detailed hearing tests to find out how common different types of hearing loss are, especially 'hidden hearing loss' where standard …