PARKINSON DISEASE (PD)

This early-stage study tests a new treatment called PDR-001 for people with Parkinson's disease. The therapy uses a harmless virus to deliver a special peptide that targets and clears a harmful protein in the brain linked to Parkinson's. The main goal is to check safety in 12 par…

This early-stage trial tests whether transplanting 10 million special nerve cells made from stem cells into the brain is safe and feasible for people with moderately severe Parkinson's disease. Ten participants aged 30-70 will receive a one-time injection into both sides of the b…

This study tests a single injection of special stem cells (XS411) into the brain of people with early-onset Parkinson's disease. The goal is to see if it is safe and can help control symptoms. About 90 participants will take part, first in a small safety phase and then in a large…

This study tests whether a daily dose of D-serine, a natural amino acid, can reduce symptoms and slow the progression of Parkinson's disease. One hundred people with early-stage Parkinson's will receive either D-serine or a placebo for 58 weeks. Researchers will measure changes i…

This study is testing a new blood test to see if it can detect Parkinson's disease in its earliest stages, even before symptoms appear. Researchers will compare blood samples from 600 people with Parkinson's and 600 healthy volunteers over two years. The goal is to create a simpl…

This study is testing a new radioactive imaging agent called 18F-mFBG to see if it can help diagnose Parkinson's disease and Lewy body dementia by looking at the heart's nerves. About 20 adults with and without these conditions will receive an injection and then have a PET scan. …

This study explores whether people with Parkinson's disease can improve their quality of life, walking speed, and mobility by managing their own exercise plans at home using telerehabilitation. Researchers will compare the results to those from a supervised exercise program. The …

This study tests whether adding robot-assisted walking training or electrical muscle stimulation to standard exercise helps people with Parkinson's disease improve balance, walking, and muscle strength. Forty participants will receive one of the two extra treatments five days a w…

This study tests whether a daily tailored amino acid supplement can improve nutrition, reduce oxidative stress, and boost physical and mental health in adults aged 60–80 with Parkinson's disease. Thirty participants will take either the supplement or a placebo for six months, wit…

This early study tests whether low-intensity focused ultrasound can safely reduce hand tremors in 12 people with Parkinson's disease, essential tremor, or dystonic tremor who haven't responded well to medication. Participants receive a single session of brain stimulation, and res…

This study compares different supervised exercise programs to see which one best improves movement, balance, and quality of life in people with Parkinson's disease. 45 adults with mild to moderate Parkinson's will participate in 8 weeks of exercise, with assessments before, after…

This study tests whether a 12-week program combining physical and mental exercises can improve walking and balance in people with moderate to advanced Parkinson's disease. 48 participants will be randomly assigned to either continue their usual care or add the special exercise pr…

This study tests whether adding motor imagery—a safe mental practice where you imagine doing movements like walking or standing—to standard physical therapy can improve balance and reduce fear of movement in people with Parkinson's disease. About 42 adults aged 40+ with mild to m…

This early study tests whether a wearable leg sleeve, called the Cionic Neural Sleeve, is safe and easy for people with Parkinson's to use at home. Ten participants with walking problems will try the device, which uses mild electrical stimulation to help with movement. The main g…

This study explores whether a 6-week empathy and compassion training program can improve quality of life for people with Parkinson's disease and their caregivers. Participants will practice mindfulness, writing, and poetry exercises. The study aims to see if these skills help wit…

This study tests whether a gentle, non-invasive brain stimulation (tDCS) given during a supervised Nordic walking program can improve walking and balance in people with Parkinson's disease. Forty participants will be randomly assigned to receive either real or fake stimulation wh…

This study uses ultrasound to measure the thickness of belly and side breathing muscles in people with Parkinson's disease. Researchers want to see if muscle thickness is linked to how severe the disease is and how strong a person's exhale is. About 36 adults with mild to moderat…

This study is testing whether special smart socks can accurately measure walking and balance in people with Parkinson's disease. Researchers will compare the socks' readings to lab equipment and track falls over time. The goal is to see if these socks can help predict who might f…

This study tests if special smart socks (DANU) can accurately measure walking and balance in people with Parkinson's. Researchers will compare results from 60 participants (30 with Parkinson's and 30 healthy older adults) during a single lab visit. The goal is to see if sock data…

This study looks at hearing in people with early-stage Alzheimer's or Parkinson's disease, compared to healthy volunteers. The goal is to find out how common certain hearing issues are, especially trouble understanding speech in noisy places even when standard hearing tests are n…