PARKINSON DISEASE (PD)

This early-stage study tests whether human umbilical cord stem cells are safe and tolerable for people with Parkinson's disease. Twenty adults aged 18 to 75 will receive either stem cells or a placebo, and researchers will monitor side effects and any changes in movement symptoms…

This early-stage study tests a new gene therapy called VGN-R08b for people with Parkinson's disease who have a specific genetic change (GBA1 mutation). The treatment is given as an injection into the brain's fluid spaces. The main goals are to check safety and see if it can impro…

This study tests whether a non-invasive treatment called remote ischemic conditioning (RIC) can improve sleep and other non-motor symptoms in people with Parkinson's disease. 48 participants with Parkinson's and insomnia will receive either active RIC (using a blood pressure cuff…

This study tests a 16-week home exercise program for 50 people with Parkinson's disease who are not very active. Participants will either do aerobic and resistance training or simple stretching, all guided by a coach via video calls. The goal is to see if the program increases da…

This study tests whether doing two things at once—like moving your arm while thinking—can improve arm function and muscle thickness in people with Parkinson's disease. About 38 participants will either receive dual-task training three times a week for 8 weeks or continue their us…

This study aims to understand how the nerves connecting the gut and brain affect Parkinson's disease. Researchers will compare people with Parkinson's, those at risk, and healthy volunteers. Participants will provide blood, stool, and saliva samples, plus undergo X-rays and colon…

This study will follow 3,000 people with Parkinson's disease over 10 years to learn how the disease changes over time and find early warning signs. Participants will have regular check-ups, tests, and scans, but no new treatments are being tested. The goal is to better understand…

This observational study looks at how a specific brain function called inhibitory control—the ability to stop or change actions—relates to walking adaptability in people with Parkinson's disease. About 50 participants will complete thinking tests, have brain activity recorded wit…

This study tests whether body-worn sensors can help doctors better adjust medication for people with Parkinson's disease who experience motor fluctuations. About 218 participants will wear sensors at home to monitor their movements, and doctors will use that data to fine-tune the…