PARKINSON DISEASE (PD)

This study compares two types of cognitive-based balance training for people with Parkinson's disease: one using virtual reality (VR) and the other combining balance exercises with mental tasks like counting. Thirty-four participants aged 40-80 will do 16 sessions over 8 weeks. R…

This early-phase trial tests a gene therapy called VGN-R08b in 17 people with Parkinson's disease who have a GBA1 gene mutation. The therapy is injected directly into the brain's fluid spaces to try to improve symptoms. The main goals are to check safety and see if it works.

This early-stage study tests whether stem cells from umbilical cords are safe for people with Parkinson's disease. About 20 adults will receive either the cells or a placebo, and researchers will monitor side effects and any changes in movement. The goal is to see if this approac…

This early-phase trial tests a new radioactive tracer called [11C]MODAG-005 that binds to abnormal protein clumps in the brain linked to Parkinson's disease and multiple system atrophy. Nine participants (patients with Parkinson's, MSA, and healthy volunteers) will receive the tr…

This pilot study will test whether active music therapy (with a therapist) or passive music therapy (just listening to music) can improve exercise ability and motivation in 28 people with Parkinson's disease. Participants will do sit-to-stand and walking tests while receiving mus…

This study tests a 16-week home-based exercise program for people with Parkinson's disease. Fifty participants will either do aerobic and resistance training or just stretching. The goal is to see if the program increases daily physical activity, improves thinking, and enhances q…

This study tests whether wearable body sensors can help doctors better adjust medication for people with Parkinson's disease who experience motor fluctuations. 218 participants will wear the sensors for 7 days before each visit, and only the experimental group's data will guide t…

This study tests a non-invasive treatment called remote ischemic conditioning (RIC) for sleep problems in people with Parkinson's disease. For 7 days, 48 participants will receive either active RIC (using a blood pressure cuff to briefly restrict arm blood flow) or a sham version…

This study investigates whether deep brain stimulation (DBS) of the subthalamic nucleus alters inflammation in people with Parkinson's disease. Researchers will measure inflammatory and neurodegenerative markers in the blood of 90 participants before and after DBS surgery, compar…

This study investigates how stimulating the vagus nerve through the ear affects stomach function and brain activity in people with Parkinson's disease. Participants receive non-invasive electrical stimulation via a device placed on the ear, and researchers measure stomach respons…

This study looks at how dopamine levels affect the ability to keep a steady beat in people with early-stage Parkinson's disease. 34 participants will do simple tapping tasks both on their usual levodopa medication and after skipping it for 12 hours. The goal is to understand whet…

This study looks at whether slowly reducing or stopping a type of bladder medication (antimuscarinics) can improve thinking and quality of life in people with Parkinson's disease. Twenty participants will go through periods of taking their usual dose and periods of tapering off, …

This natural history study will follow 3,000 people with Parkinson's disease over 10 years to understand how the disease progresses and to find early diagnostic markers. Participants will undergo regular check-ups, imaging scans, and lab tests, but no experimental treatments will…

This study looks at how the nerves connecting the gut and brain affect Parkinson's disease. Researchers will compare people with Parkinson's, those at risk, and healthy volunteers. Participants will give blood, stool, and saliva samples, have X-rays and colon exams, and answer qu…

This observational study looks at whether a specific brain function called inhibitory control — the ability to stop or change actions — is linked to how people with Parkinson's disease adjust their walking to step over obstacles. Researchers will measure brain activity with EEG a…