New e. coli vaccine enters first human safety trial

NCT ID NCT07122986

Recruiting now ⭐️ VACCINE ⭐️ Sponsor: Pfizer Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

Pfizer is testing several experimental vaccines designed to protect against E. coli bacteria. This early-stage study involves 310 healthy adults aged 18 to 64. The main goal is to check if the vaccines are safe and tolerable, not yet whether they work. Participants will receive two shots six months apart and be monitored for side effects like injection-site pain, fever, and fatigue.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: E. coli vaccine
What this could lead to: If this vaccine proves safe and effective, it could help prevent E. coli infections, which can cause severe diarrhea and kidney damage.
What could go wrong: This is an early Phase 1 trial focused only on safety in healthy adults. It is too soon to know if the vaccine actually prevents infection, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

escherichia coli infection prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEALTHY PARTICIPANTS

Contacts and locations

Locations

Alliance for Multispecialty Research, LLC
RECRUITING

Knoxville, Tennessee, 37909, United States
Alliance for Multispecialty Research, LLC
RECRUITING

Knoxville, Tennessee, 37920, United States
Anaheim Clinical Trials, LLC
RECRUITING

Anaheim, California, 92801, United States
CTI Clinical Research Center
RECRUITING

Cincinnati, Ohio, 45212, United States
Diablo Clinical Research, Inc.
RECRUITING

Walnut Creek, California, 94598, United States
Miami Eye Institute
RECRUITING

Hollywood, Florida, 33024, United States
NYU Langone Health
RECRUITING

New York, New York, 10016, United States
Orange County Research Center
RECRUITING

Lake Forest, California, 92630, United States
Research Centers of America
RECRUITING

Hollywood, Florida, 33024, United States
Senders Pediatrics
RECRUITING

South Euclid, Ohio, 44121, United States
University Eye Specialists, P.C. (Ophthalmologist)
RECRUITING

Maryville, Tennessee, 37803, United States

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