Scientists probe Brain's wiring to boost depression treatment

NCT ID NCT07071259

Recruiting now Knowledge-focused Sponsor: Institut National de la Santé Et de la Recherche Médicale, France Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 08, 2026 · Updated 2 times

Summary

This study aims to better understand how the brain's prefrontal cortex is organized, specifically the part linked to mood and thinking. Researchers will use advanced MRI and TMS-EEG in 34 healthy adults to map connections between brain regions. The goal is to improve targeting of a therapy called rTMS, which is used for severe depression but currently works for only 20-40% of patients.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Transcranial magnetic stimulation (TMS) and high-field MRI
What this could lead to: If successful, this could lead to more precise targeting of brain areas for rTMS therapy, potentially improving depression treatment outcomes.
What could go wrong: This is a small, early-stage study in healthy volunteers, not patients. The findings may not translate directly to clinical practice, and the approach is still experimental.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DORSOLATERAL PREFRONTAL CORTEX EEG HEALTHY PARTICIPANTS MAGNETIC STIMULATION MRI RTMS STIMULATION

Scientists probe Brain's wiring to boost depression treatment

Summary

What this could mean

Get notified about this study

As listed by the trial registrant

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