HEALTHY PARTICIPANTS

This study tested a new drug called BGB-45035 for the first time in humans. It looked at safety in healthy volunteers and then in people with autoimmune skin diseases like atopic dermatitis (eczema) and prurigo nodularis (a condition causing intensely itchy bumps). The goal was t…

This early-stage study tested a new drug called AZD6234 in 104 healthy adults with overweight or obesity. The main goal was to check if the drug is safe and how the body processes it. Participants received either the drug or a placebo, and researchers monitored side effects and d…

This early-stage study tested a new drug called AZD4144 in 28 adults with obesity to see if it is safe and how it affects inflammation markers in the blood. Participants took either the drug or a placebo daily for a short time. The goal was to check for side effects and measure c…

This early-stage trial tested an experimental drug called IBI356 in 99 healthy volunteers and people with atopic dermatitis (eczema). The main goal was to check if the drug is safe and how the body processes it. Participants received either a single dose, multiple doses, or a pla…

This study tests whether a daily probiotic supplement (Limosilactobacillus reuteri) can reduce symptoms like heartburn and stomach pain in healthy adults who have occasional upper gut discomfort. About 324 people will take either the supplement or a placebo for 8 weeks and report…

This completed trial tested PeptiSleep, a plant-based supplement made from rice protein, to see if it improves sleep quality in healthy adults. 120 participants took either PeptiSleep or a placebo daily for 6 weeks while wearing a sleep tracker and completing surveys. The study m…

This study tested whether a special electronic syringe (Dentapen) causes less pain and stress during dental numbing shots compared to a regular syringe. Forty healthy adults getting teeth pulled for braces took part. Researchers measured pain using a 0-100 scale and stress by tra…

This study tested whether a 4-week program of eccentric hip exercises using elastic bands could improve hip strength and agility in young male basketball players. Twenty-one healthy athletes aged 15-18 were split into two groups: one did the elastic band exercises plus regular tr…

This pilot study tested whether a daily probiotic and grape extract supplement (in a capsule or chocolate bar) could improve stress and sleep in 40 healthy adults with moderate stress. Participants took the product for 4 weeks, and researchers measured changes in perceived stress…

This early-stage trial tested a single dose of the experimental drug IBI3002 in 52 healthy volunteers and people with mild to moderate asthma. The main goal was to check safety and how the body processes the drug. Researchers monitored side effects and drug levels in the blood ov…

This study tested whether a short, 3-minute neck stretch could lower blood pressure in 25 healthy adults. Participants did a gentle stretch on one side of the neck, and researchers measured blood pressure, tissue stiffness, and heart rate changes. The goal was to see if stretchin…

This study investigates whether type 2 diabetes changes the levels of key growth factors and inflammatory markers in Albumin Platelet-Rich Fibrin (Alb-PRF) membranes—a blood-derived material used to support wound healing and dental tissue repair. Researchers will compare Alb-PRF …

This early-stage study tests an experimental oral drug called LTG-321 in 236 healthy adults aged 18-55. The main goal is to check safety and how the body processes the drug. Researchers will also measure pain tolerance using a cold water test and see if a high-fat meal affects dr…

This early-phase trial tested the safety and how the body processes a new drug called LY03015 in 24 healthy adults from Chinese and Caucasian backgrounds. Participants took a single dose and were monitored for about a month. The study is complete and focused on gathering basic sa…

This study looks at how healthy men absorb, break down, and get rid of a test medicine called AZD4144. Eight men aged 30 to 65 will receive a single dose either by mouth or through a vein. A tiny radioactive tag lets researchers follow the drug's path in the body.

This completed Phase 1 study tested whether a single tablet combining laroprovstat and rosuvastatin works as well as taking the two drugs separately. 44 healthy adults aged 18 to 55 took part in a crossover design, receiving different formulations. The goal was to measure how muc…

This study measured how much of the pain-relief gel Voltaren (diclofenac) ends up in rinse water after washing. 33 healthy adults applied the gel either by hand or with an applicator, then washed or wiped the area. Researchers tested the rinse water to see how much drug was lost.…

This early-stage study looked at how food and two other drugs (itraconazole and carbamazepine) affect the way healthy adults process a new compound called INCB123667. Fifty-one participants took single doses of the compound under different conditions. The goal was to gather safet…

This study compared muscle oxygen levels in the thigh muscle of 34 people with and without knee osteoarthritis. Participants did a simple squat exercise while a device measured oxygen in the muscle. The goal was to understand how knee OA affects muscle function and recovery, whic…

This study looked at whether eating carbohydrates at the end of a pre-exercise meal (instead of at the start) changes how the body burns fat and carbs during exercise and affects cycling performance. Eighteen healthy, trained male athletes ate a standard meal in two different ord…

This early-stage study tested different oral versions of the drug AZD5004 in 65 healthy adults. The goal was to see how the body absorbs and processes each version, and whether taking it with food changes those effects. The study is complete, but results are not yet available.

This study looked at how 12 months of personalized endurance training—swimming, cycling, and running—affects the body and mind of healthy adults who were not regular exercisers. Fifty-eight people aged 19-39 took part, with some training up to 20 hours a week and others serving a…

This study looked at how much of the drug rozanolixizumab appears in breast milk after a single dose. Fifteen healthy lactating women who had already decided to stop breastfeeding took part. Researchers measured drug levels in milk over 7 days to estimate how much a baby might be…

This study looked at how well two different tablet versions of an experimental drug (PF-07220060) enter the bloodstream. It also tested whether taking the drug with food or with a stomach acid medication (rabeprazole) changes absorption. About 113 healthy adults aged 18–65 took p…

This study looked at how two common drugs—carbamazepine (a strong inducer) and itraconazole (a strong inhibitor)—affect the levels of a single dose of AP31969 in the blood of 28 healthy adults. The goal was to understand how these interactions might change the drug's breakdown, w…

This study looked at how a type of ear acupuncture (using tiny press needles) changes brain connections and nerve activity in 40 healthy adults. Researchers used brain scans to see if the acupuncture affects areas linked to emotion and body awareness, similar to vagus nerve stimu…

This study tested whether a short virtual reality (VR) self-help program could increase hope and well-being in young adults aged 18-30. Forty healthy participants completed five sessions, starting with an in-person VR experience followed by self-guided audio and video materials. …

This study looked at what makes it easier or harder for Turkish young people (ages 15-24) to be physically active. Researchers surveyed 318 healthy volunteers about their activity levels, stress, and daytime sleepiness. The goal is to understand these factors so better programs c…

This study looked at 100 children aged 9 to 11 to see if pinch grip strength is related to how well they write. Kids did a handwriting test and had their pinch strength measured with a special gauge. The goal was simply to understand the connection better, not to test any treatme…

This completed Phase 1 trial tested the safety of a new drug called CDX-622 in 85 healthy adults aged 18-55. Participants received either CDX-622 or a placebo (saline) by infusion or injection. The study measured side effects, drug levels in the blood, and immune responses. Since…

This completed Phase 1 study looked at how much of the COVID-19 treatment nirmatrelvir/ritonavir (Paxlovid) gets into breast milk. Eight healthy breastfeeding women took the drug by mouth three times over two days. Researchers collected breast milk samples to measure drug levels,…

This completed Phase 1 study looked at how a single dose of the drug Quemliclustat (with a tiny radioactive tag) is broken down and removed from the body. Eight healthy adult men received the drug by IV and provided blood, urine, and stool samples. The goal was purely to understa…

This study tested how a single upper-body resistance training session, with or without added static stretching, affects blood vessel function, muscle performance, and blood pressure in 27 healthy men. Participants were measured before, right after, and 30 minutes after exercise. …

This completed Phase 1 study looked at how a new drug called elenestinib affects the way the body processes midazolam (a sedative) and a common birth control pill. Twenty healthy adult women took these drugs with and without elenestinib, and researchers measured drug levels in th…

This study looked at how two different versions of the drug LY4064809 enter the bloodstream and how long the body takes to remove them. It involved 24 healthy adults who stayed at a research center for about a month. The goal was to gather information, not to treat any disease.

This study looked at how a high-fat, high-calorie meal changes the amount of two drugs (zibotentan and dapagliflozin) in the blood of healthy people. Twenty-six adults took a single dose of the combined pill once after eating and once on an empty stomach. The goal was to see if f…

This study looked at whether a roller massage (like using a foam roller) can temporarily lower blood pressure in healthy young adults. Researchers measured changes in tissue hardness and blood pressure after a short massage session. The goal was to understand how massage might af…

This study tested a single dose of the drug AZD4144 in 41 adults with severe kidney disease, end-stage kidney disease, and healthy volunteers. Researchers measured how the drug moves through the body and checked for side effects. The goal was to understand how kidney problems aff…

This completed Phase 1 trial tested how a high-fat or low-fat meal changes the way the body absorbs ammoxetine, a potential antidepressant. Eighteen healthy adults each took a single 60 mg dose under three different meal conditions. The goal was to see if food affects drug levels…

This study looked at how taking ammoxetine tablets with or without food changes the drug levels in the body. Fourteen healthy adults participated in a two-period crossover design. The goal was to understand food's impact on drug absorption to guide future dosing recommendations.

This early-stage study tested the safety and tolerability of a new drug called LY4060874 in 121 healthy adults. Participants were monitored for side effects and how the drug moved through their bodies. The study did not aim to treat any disease, but to gather important safety inf…

This early-stage study in 28 healthy adults looks at how food and the drug cobicistat change the way plixorafenib (FORE8394) is processed by the body. Participants take single doses under different conditions—fasted, with low-fat or high-fat meals, and with or without cobicistat.…

This study tested whether a commercially available high-protein yoghurt drink helps muscles recover after intense exercise. 62 healthy adults aged 18-45 took part. Researchers measured amino acid levels in the blood and markers of muscle damage, inflammation, and physical functio…

This completed Phase 1 study looked at how healthy men absorb, process, and eliminate the experimental drug PF-07220060. Twelve participants received the drug by mouth or by injection. Researchers measured the drug and its breakdown products in blood, urine, and stool to understa…

This completed Phase 1 study looked at how the cancer drug capivasertib changes the way the body processes rosuvastatin, a common cholesterol-lowering medicine. Twenty healthy adults took rosuvastatin alone and then with capivasertib to compare drug levels in their blood. The res…

This completed Phase 1 study looked at how the drug MK-8527 moves through the body in people with mild or moderate liver impairment compared to healthy volunteers. Researchers measured drug levels in the blood over time to understand how liver function affects the drug. The study…

This study measured how the number of calories and the time of day you eat affect your body's energy use and blood vessel health. Twenty healthy adults ate test meals while researchers tracked their metabolism and pulse. The goal was to understand how meal choices influence metab…

This study tested whether foam rolling the neck could change blood pressure and improve neck movement in 24 healthy young adults. Participants used a massage roller on the right side of their neck for four short sessions. Researchers measured blood pressure, heart rate, tissue ha…

This study looked at how the experimental prostate cancer drug opevesostat moves through the body in men with moderate liver impairment compared to healthy men. Sixteen male participants received a single dose, and researchers measured drug levels over time. The goal was to under…

This completed phase 1 study tested how quickly an inhaled form of alprazolam (Staccato) affects brain activity compared to intravenous midazolam and nasal diazepam. Fifty-five healthy adults received single doses of each drug in a crossover design. Researchers used EEG brain wav…

This early-stage study tested the safety and how the body processes a single dose of donzakimig in 32 healthy Chinese and Japanese adults. Participants received either the drug or a placebo, and researchers monitored for side effects and drug levels in the blood. The goal was to …

This completed study tested how reliable a digital dynamometer is for measuring handgrip strength in 50 healthy adolescents aged 15-16. Participants performed standardized strength tests for upper and lower limbs, and results were compared across two sessions. The goal is to esta…

This completed study tested whether a mild electrical current applied to the scalp (tDCS) can change how the brain handles stress and imagines future events. Sixty healthy adults underwent brain scans while receiving either real or fake stimulation. The goal was purely to learn m…

This completed Phase 1 study looked at how vimseltinib affects the way the body processes metformin, a common diabetes drug. Twenty-two healthy men took vimseltinib and metformin to measure drug levels and check for side effects. The goal was to understand drug interactions, not …

This study tested different versions of the drug TEV-56286 (emrusolmin) in 47 healthy adults to see how well the body absorbs each form. Participants took a single dose of either a new formulation or a reference capsule, and researchers measured drug levels in the blood. The goal…

This completed early-phase study looked at how healthy adults respond to the rabies vaccine when given alone or with an immune-boosting shot (rabies immune globulin). Thirty participants received different combinations of vaccine and immune globulin to compare antibody levels ove…

This study tested whether real-time feedback from a virtual trainer avatar during VR exercise improves how people feel and how accurately they move. Twenty-eight healthy adults did three short VR exercise sessions with no feedback, verbal feedback, or combined verbal-gestural fee…

This completed Phase 1 study tested how a new drug called AZD5004 interacts with the antifungal itraconazole and with birth control pills in 51 healthy volunteers. The goal was to measure how these drugs affect each other's levels in the body, not to treat any disease. Results wi…

This study compared a new biosimilar drug called CHS-1420 to the original Humira (adalimumab) in 238 healthy Chinese adults. Each person received a single injection of either CHS-1420 or Humira, and researchers measured how the drug moved through their blood over time. The goal w…

This study checked if a new insulin (NKF-INS(A)) is similar to two already-approved insulins (US-NovoLog and EU-NovoRapid). Fifty-four healthy men received a single dose of each insulin in random order. Researchers measured how fast the insulin entered the blood and how it contro…

This study looked at whether a 12-week exercise program (three times a week) could improve thinking skills in healthy adults aged 50 to 80. Researchers measured hormones like leptin and irisin, as well as other brain-related chemicals, before and after the program. The goal was t…

This study looked at how a drug called vimseltinib affects two important proteins (BCRP and OATP1B1) that help move medicines in the body. Twenty healthy men took rosuvastatin, a common cholesterol drug, with and without vimseltinib to see if vimseltinib changes how much rosuvast…

This study looked at how taking the drug Admilparant with or without food changes the amount of drug in the blood. Fifty-six healthy adults took the tablet in two different conditions. The results will help doctors know whether to take this medicine with meals.

This early-phase trial tested whether a 5-day course of an oral NAD+ supplement (LNAD+) could raise NAD+ levels and change biological markers in 60 healthy adults aged 45-75. Participants took either the supplement or a placebo, and researchers measured NAD+ in blood cells and ci…

This study tested a new propellant (HFA-152a) in salbutamol inhalers to see if it works like the current propellant (HFA-134a). Sixty healthy adults aged 18-55 received single doses of salbutamol via both inhalers. The goal was to measure how much drug gets into the blood and how…

This study looked at how an experimental drug called AZD0780 affects the way the body processes metformin, a common diabetes medicine. Fourteen healthy volunteers took both drugs, and researchers measured drug levels in the blood. The goal was purely to gather information on drug…

This study looked at how a single dose of a drug called INCB123667 moves through and leaves the bodies of 9 healthy men. The drug was tagged with a tiny amount of radioactivity to track it in blood, urine, and stool. The goal was to understand how the drug is processed and elimin…

This study looked at how the brain naturally reduces pain when a person feels two painful sensations at the same time. Researchers tested 24 healthy University of Washington students by giving brief painful stimuli to the foot and wrist. The goal was to understand whether attenti…

This study tested how different versions of the experimental drug ziltivekimab move through the body when given as a single injection under the skin. It compared two different formulas and two injection methods: a manual syringe and a pen-injector. The study involved 267 healthy …

This study tested whether taking a daily 5-minute bath in hot water (45°C) for two weeks could help healthy young adults adapt to heat. Researchers measured changes in body temperature, heart rate, and other signs of heat stress in 26 participants. The goal was to see if such a s…

This study tested whether a short, personalized virtual reality (VR) experience could help general practitioners (GPs) feel better and become more flexible in their thinking. Twenty-one healthy GPs took part in a single session where they used a VR headset and then reflected on t…

This study looked at whether a new drug called clofutriben affects how the body handles two common medicines, midazolam and prednisolone. Sixteen healthy adults took clofutriben daily for 16 days along with single doses of the other drugs. The goal was to measure drug levels in t…

This early-stage study tested a new drug called AZD8965 in 147 healthy adults, including Japanese and Chinese participants. The main goal was to check if the drug is safe and how the body processes it, both with and without food. No treatment was given for any disease, so this st…

This study tested whether a 40-second magnetic pulse to the left or right front part of the brain changes how quickly healthy adults react to emotional versus neutral images. Ninety-one participants received either real or fake stimulation and then performed a computer task. The …

This early study tested a new medicine called NNC0650-0013 in 11 healthy men to see if it is safe and how the body processes it. The drug is being developed for type 2 diabetes. Participants received a single injection under the skin or into a vein, and some got a placebo. The st…

This study tested whether a 5-week nature-based therapy program—featuring guided walks and mindfulness in a coastal urban park—could improve stress resilience and quality of life in 100 healthy adults. Participants attended three 60-minute sessions per week and were followed for …

This completed Phase 1 study looked at how a single dose of the insulin drug THDB0206 behaves when injected into the upper arm, abdomen, or thigh. Twenty-seven healthy Chinese adults each received the same dose at all three sites in a random order. The goal was to see if the inje…

This study tested whether the drug tozorakimab enters the body the same way when given by two different injection devices: an autoinjector and a prefilled syringe. 254 healthy adults each received one injection. The goal was to see if the devices deliver the drug consistently, wh…

This completed study tested a new tablet version of the drug semaglutide in 264 healthy volunteers. The goal was to measure how much of the drug gets into the blood with the new tablet compared to the current version. Participants took different doses over 21 weeks to see which f…

This study looked at how breathing in simulated wildfire smoke for just one hour affects healthy adults. Researchers measured a blood marker called p-tau, which is linked to memory problems, and tested thinking skills before and after exposure. The goal was to see if short-term s…

This study looked at whether short daytime naps help adolescent soccer players perform better. Sixteen male players from a Turkish club tried no nap, a 25-minute nap, or a 45-minute nap before agility and sprint tests. The 45-minute nap improved agility and made exercise feel eas…

This study tested two different ultrasound-guided nerve stimulation protocols on 86 healthy adults to see which better improves handgrip strength. Participants received a single session of either high-frequency (100 Hz) or low-frequency (10 Hz) stimulation to the median nerve. Th…

This early-stage study tested the safety of a new drug called ATX101 in 24 healthy adults aged 18 to 50. Participants received a single dose through a vein, and researchers monitored for side effects and how the drug moved through the body. The goal was not to treat any disease, …

This early-stage study involved 18 healthy adults to see how a new tablet version of the drug minzasolmin is absorbed compared to an older capsule form, and whether food changes absorption. Participants took single doses under fasting or fed conditions. The study is complete and …

This early-stage trial tested the safety and tolerability of a single dose of UCB9741 in 40 healthy adults, including both Caucasian and Japanese participants. Half received the drug and half a placebo, with neither participants nor researchers knowing who got what. The study foc…

This completed phase 1 study looked at how three common drugs—an antifungal (itraconazole), an antibiotic (rifampin), and acid reducers (esomeprazole, famotidine)—change the way a new experimental drug (INCB161734) moves through the body. Sixty-three healthy adults aged 18 to 55 …

This study looked at how well two different versions of an experimental oral drug (deuterium deuremidevir) are absorbed by the body. It involved 18 healthy Chinese adults aged 18 to 45. Participants took each version once, and researchers measured drug levels in their blood to co…

This early-stage study tested the safety and how the body handles an inhaled drug called AZD4604 in 56 healthy Japanese and Chinese adults. Participants received either the drug or a placebo as a dry powder inhaler. The goal was only to check for side effects and measure drug lev…

This completed study tested whether a short session of neck stretching or using a massage roller on the neck could improve flexibility not only in the neck but also in the hip. Thirty healthy adults participated, and researchers measured range of motion and tissue stiffness. The …

This study tested how the experimental drug casdatifan interacts with two common medications in 14 healthy adults. Participants received casdatifan alone and then with itraconazole or phenytoin to see how these drugs affect casdatifan levels in the body. The goal was to gather sa…

This early-stage study tested a single dose of a new drug, AZD5148, in 84 healthy adults to see if it is safe and how the body processes it. Participants received the drug either as a shot into a muscle or a vein, or a placebo. The study did not aim to treat any disease, only to …

This early-stage study tested the safety and how the body handles a new drug called AZD6793 in 39 healthy Japanese and Chinese adults. Participants received either the drug or a placebo, and researchers monitored for side effects and drug levels in the blood. The study was comple…

This completed Phase 1 study looked at how the drug MK-5684 behaves in the body of men with severe kidney disease or end-stage renal disease compared to healthy men. Twenty-four participants received a single dose, and researchers measured drug levels in the blood over time. The …

This early-stage study looked at how well two tablet versions of the experimental drug ZN-A-1041 are absorbed compared to a capsule form. It involved 18 healthy adults and also planned to check if food or a stomach-acid drug changes absorption, though that part was canceled. The …

This early-stage study tested a new drug called INCB160058 in 137 healthy adults aged 18 to 55. The main goal was to check the drug's safety and how the body processes it, not to treat any disease. Participants took a single dose by mouth, and researchers monitored side effects a…

This study looked at how a new drug called AZD5004 affects the way the body processes several common medicines, including statins (for cholesterol) and repaglinide (for diabetes), in healthy adults aged 18 to 55. It also checked how another drug, erythromycin, affects AZD5004. Th…

This study looked at how a long-acting painkiller (nalbuphine ER) affects and is affected by two lung fibrosis drugs (pirfenidone and nintedanib) in 132 healthy adults. Researchers measured drug levels in the blood and monitored for side effects. The goal was to see if these drug…

This early-phase trial tested the safety and processing of a new drug called S-740792 in 99 healthy adults. Participants received single or multiple doses of the drug as a liquid or tablet, and some received a placebo. The goal was to gather safety data and understand how the bod…

This early-stage study tested the safety and how the body handles a new drug called PF-06414300 in 63 healthy adults. Participants received either the drug or a placebo in single or multiple doses. The study is complete and focused on measuring side effects and drug levels in the…

This study tested whether eccentric cycling (where you resist the pedals) is better than regular concentric cycling for improving muscle strength and fitness in sedentary adults. Forty-five healthy but inactive people were split into three groups: high-intensity eccentric interva…

This study tested a new tablet version of semaglutide (the drug in Ozempic and Rybelsus) in 121 healthy men. Researchers wanted to see how different amounts of water (50 mL vs 120 mL) and different delays before breakfast (30, 60, or 120 minutes) affect drug levels in the blood. …

This completed study tested the safety of 18 different skin patches on 26 healthy adults. Patches were applied for 24 hours and skin reactions like redness and swelling were checked. The goal was to see if the patches cause irritation, not to treat any disease.

This observational study examined how different ways of carrying a school backpack affect pressure on the soles of the feet in 92 healthy adolescents aged 12–18. Participants stood and walked on a pressure-sensitive mat under four conditions: no backpack, backpack on both shoulde…

This study looked at how immersive virtual reality affects memory and distraction. 16 healthy adults tried to remember word lists while using VR or not. Researchers measured how many words they recalled and how distracted they felt. The goal was to learn more about how VR changes…

This study tested how well healthy adults tolerate immunoglobulin G (IgG) injections given under the skin using different techniques. Researchers measured pain, injection-site reactions, and fluid leakage in 82 participants. The goal was to find the most comfortable and safe way …

This completed Phase 1 study enrolled just 5 healthy men aged 35–55 to see how a single oral dose of the experimental drug INCB099280 (with a tiny radioactive label) is absorbed, broken down, and eliminated. Researchers measured radioactivity in urine and feces and checked drug l…

This study measured blood sugar levels after eating in 20 healthy adults—10 with normal weight and 10 with overweight or obesity. Participants ate white or wholemeal bread with orange juice and butter, and their blood glucose was checked over two hours. The goal was to see if bod…

This early-stage trial tested the safety and tolerability of an experimental drug called AZD2389 in 120 healthy volunteers. Participants received either the drug or a placebo as single or multiple doses. The study focused on monitoring side effects and how the drug moves through …

This completed phase 1 study looked at how the experimental cancer drug camizestrant affects the breakdown of midazolam (a sedative) and how carbamazepine (a seizure drug) affects camizestrant levels. Forty healthy postmenopausal women took part. The goal was to gather safety and…

This completed study tested whether whole-wheat bread enriched with carob molasses pulp and germ can improve blood sugar response and antioxidant capacity in healthy adults. Twenty volunteers aged 19-35 ate both standard and enriched breads, and their blood was tested over three …