HEALTHY PARTICIPANTS

This early-stage study tested a new daily pill, AZD4144, in 28 adults with obesity to see if it is safe and how it affects body inflammation. Participants took either the drug or a placebo for a short time. The main goals were to check for side effects and measure changes in bloo…

This early-stage study tested a new drug called AZD6234 in 104 healthy adults with overweight or obesity. The main goal was to check if repeated doses are safe and tolerable compared to a placebo. Researchers also measured how the drug moves through the body. This is a first step…

This study tested whether a daily probiotic and grape extract, taken as a capsule or in a chocolate bar, could help healthy adults manage stress and improve sleep. Forty moderately stressed adults took the product for 4 weeks. Researchers measured changes in perceived stress and …

This early-phase trial tested the safety and tolerability of a new drug called IBI356 in 99 participants: healthy volunteers and people with atopic dermatitis (a type of eczema). The study was completed and focused on checking for side effects and how the drug moves through the b…

This study tested whether a short session of static neck stretching can lower blood pressure in healthy adults. 25 volunteers participated, and researchers measured blood pressure, tissue stiffness, and heart rate before and after stretching. The goal was to see if stretching rel…

This early-stage study tested a single dose of a new drug called IBI3002 in 52 healthy adults and people with mild-to-moderate asthma. The main goal was to check if the drug is safe and how the body processes it. Participants were randomly assigned to receive either the drug or a…

This study tested PeptiSleep, a plant-based capsule, in 120 healthy adults over 6 weeks. Participants took either PeptiSleep or a placebo daily and wore a sleep tracker. The goal was to see if PeptiSleep improves sleep quality, morning alertness, and overall well-being.

This study tested whether a special dental syringe called Dentapen causes less pain and stress during numbing shots compared to a regular syringe. Forty healthy people who needed a tooth extraction took part. They rated their pain and had their heart rate monitored to measure str…

This study explored whether being overweight or obese leads to higher blood sugar spikes after eating. Twenty healthy adults (10 normal weight, 10 overweight/obese) ate bread with orange juice and butter, and their blood sugar was measured over two hours. The goal was to understa…

This study measured how a single workout session, with or without stretching, affects blood vessel function and blood pressure in 27 healthy men. Participants did resistance training alone, resistance training plus stretching, or rested. The goal was to see if adding stretching c…

This study looked at how a single dose of the drug INCB099280 is absorbed, broken down, and eliminated from the body. Five healthy men took one pill, and researchers measured the drug and its byproducts in their blood, urine, and stool. The goal was purely to understand the drug'…

This early-stage study tested a single dose of a new drug, AZD5148, in 84 healthy adults to see if it is safe and how the body processes it. Participants received the drug either as a shot into a muscle or through a vein. The study did not aim to treat any disease, but to gather …

This study looked at how a new experimental drug, AZD5004, affects the way the body processes several common medicines, including statins (for cholesterol) and repaglinide (for diabetes). It also checked how another drug, erythromycin (an antibiotic), affects AZD5004. The study i…

This study looked at whether short daytime naps help teenage soccer players perform better. Sixteen male athletes from a Turkish club tried no nap, a 25-minute nap, or a 45-minute nap before agility and sprint tests. The 45-minute nap improved agility and made players feel less t…

This study looked at whether a single session of roller massage can lower blood pressure in healthy young adults. 29 participants received both a roller massage and a control session. The researchers measured changes in blood pressure and tissue hardness to understand how massage…

This study looked at how different cycling workouts affect muscle strength and fitness in 45 sedentary but healthy adults. Participants did either eccentric (resisting the pedal) or concentric (normal pedaling) cycling for 14 weeks. The goal was to see which type of training give…

This study looked at how taking plixorafenib with food or with another drug (cobicistat) changes the amount of plixorafenib in the blood. It involved 28 healthy adults aged 18 to 55. The goal was to gather safety and drug-level information, not to treat any disease.

This study looked at how a short, painless brain stimulation technique called continuous theta burst stimulation (cTBS) changes the way healthy young adults pay attention to emotional pictures, like a crying child or a smiling baby. 91 participants received either real or fake st…

This study looked at how healthy men absorb, process, and eliminate a drug called PF-07220060. Twelve men took the drug by mouth or by mouth plus an injection. Researchers measured the drug in blood, urine, and stool to understand how it travels through the body. This study did n…

This study looked at how the experimental prostate cancer drug opevesostat (MK-5684) moves through the body in men with moderate liver impairment compared to healthy men. Sixteen male participants received a single dose, and researchers measured drug levels over time. The goal wa…

This study looked at how three common medications—itraconazole, rifampin, and acid reducers—change the way the body handles a drug called INCB161734. Sixty-three healthy adults aged 18 to 55 took part. The goal was to measure drug levels and safety, not to treat any disease.

This study looked at how foam rolling the neck area affects blood pressure and neck flexibility in 24 healthy young adults. Researchers measured changes right after rolling and checked if more rolling led to bigger effects. The goal was to learn more about how this simple techniq…

This study tested a new medicine called PF-06414300 in 63 healthy adults aged 18-65. The goal was to see how safe it is and how the body processes it, not to treat any disease. Participants received either the drug or a placebo in single or multiple doses, and researchers monitor…

This study tested whether a store-bought high-protein yogurt drink helps muscles recover after intense exercise. Healthy adults aged 18 to 45 drank either the protein drink, a pure protein drink, or a flavored water placebo. Researchers measured amino acid levels in the blood and…

This study looked at how quickly and completely the experimental drug ziltivekimab enters the body when given as a shot under the skin. Researchers compared three different versions of the drug and two injection methods—a regular syringe and a pen-injector. A total of 267 healthy…

This study looked at how the drug MK-5684 stays in the body of men with severe kidney failure or end-stage kidney disease compared to healthy men. Researchers measured drug levels in the blood over time. The goal was to understand how kidney problems affect the drug, not to treat…

This study looked at whether adding carob molasses and germ to whole-wheat bread can help control blood sugar and increase antioxidants in healthy adults. Twenty volunteers aged 19-35 ate both standard and enriched bread on separate days, and their blood was tested over three hou…

This study looked at how taking a drug called ammoxetine with or without food changes its levels in the blood. Fourteen healthy adults took the drug under both conditions to measure absorption. The goal was to gather information for future dosing, not to treat any disease.

This study looked at how the drug camizestrant affects another drug (midazolam) and how carbamazepine affects camizestrant in 40 healthy postmenopausal women. The goal was to measure drug levels in the blood, not to treat any disease. Results help guide future dosing for patients…

This study looked at how two different versions of the drug LY4064809 enter the bloodstream and how long the body takes to remove them. It involved 24 healthy adults who stayed at a research center for about one month. The goal was to gather information, not to treat any disease.

This early-stage study tested the safety and how the body handles an inhaled drug called AZD4604. It involved 56 healthy Japanese and Chinese volunteers who received either the drug or a placebo. The goal was to check for side effects and measure drug levels in the blood, not to …

This study looked at how a single dose of a drug called INCB123667 is absorbed, broken down, and removed from the body. Nine healthy men took the drug, which had a tiny radioactive tag, so researchers could measure it in blood, urine, and stool. The goal was purely to understand …

This study looked at how the brain naturally reduces pain when a person feels two painful sensations at the same time. Researchers measured pain ratings and attention levels in 24 healthy university students. The goal was to understand whether focusing attention on one pain can h…

This study looked at how capivasertib, a cancer drug, changes the way the body handles rosuvastatin, a cholesterol-lowering statin. Twenty healthy adults took rosuvastatin alone and then with capivasertib to measure differences in drug levels. The goal was to understand potential…

This early-stage study tested a new medicine called NNC0650-0013, which may one day treat type 2 diabetes, in 11 healthy men. The main goal was to check safety and how the drug moves through the body. Participants received a single injection of the drug or a placebo. The study la…

This study tested whether a medicine called tozorakimab enters the body the same way when given by two different injectors (a prefilled syringe or an autoinjector). It involved 254 healthy adults and did not aim to treat any disease. The goal was simply to compare how the drug mo…

This study checked whether a new medicine called CHS-1420 behaves like the approved drug Humira in the body. It involved 238 healthy Chinese adults who received a single dose of either drug. The goal was not to treat any disease, but to see if the two drugs are similar enough for…

This study looked at how the drug casdatifan interacts with two other drugs (itraconazole and phenytoin) in 14 healthy adults. The goal was to measure how these drugs affect the levels of casdatifan in the blood. This information helps doctors understand how to adjust casdatifan …

This early-stage study tested a new drug called INCB160058 in 137 healthy adults aged 18 to 55. The main goal was to check the drug's safety and how the body absorbs and processes it, not to treat any disease. Participants took a single dose of the drug or a placebo, and research…

This study looked at whether a 12-week exercise program (three times a week) could improve thinking skills in healthy adults aged 50 to 80. Researchers measured hormones like leptin and irisin, as well as other markers linked to brain health. The goal was to understand how exerci…

This study tested how quickly an inhaled form of alprazolam (Staccato) starts working compared to two other sedatives given by IV or nasal spray. Fifty-five healthy adults received single doses of each drug on different days while their brain activity was monitored with an EEG. T…

This study looked at how taking admilparant tablets with or without food changes the amount of drug in the blood. It involved 56 healthy adults and was completed by Bristol-Myers Squibb. The goal was to gather information, not to treat any disease.

This study looked at how the drug MK-8527 moves through the body in people with mild or moderate liver impairment compared to healthy volunteers. Researchers measured drug levels in the blood over time to understand how liver function affects the drug. The study involved 18 adult…

This study looked at how the experimental drug AZD0780 changes the way the body processes metformin, a standard diabetes medication. Fourteen healthy adults took both drugs in a fixed order, and researchers measured drug levels and side effects. The goal was purely to gather info…

This study looked at how a long-acting painkiller (nalbuphine ER) interacts with two lung fibrosis drugs (pirfenidone and nintedanib) in 132 healthy adults. Researchers measured drug levels in the blood and checked for side effects. The goal was to see if these drugs can be safel…

This study looked at how two different forms of an experimental drug (deuterium deuremidevir) are absorbed by the body. It involved 18 healthy Chinese adults who took each version once, with a break in between. The goal was to measure drug levels in the blood, not to treat any di…

This study looked at how a gentle electrical current applied to the brain (tDCS) changes stress responses and the ability to imagine future events. Sixty healthy adults aged 18-30 took part in one MRI session while receiving either real or fake stimulation. The goal was to unders…

This study looked at how breathing in simulated wildfire smoke for one hour affects healthy adults' thinking and memory. Researchers measured a blood marker called p-tau217, which is linked to cognitive decline, and compared results after breathing clean air versus smoky air. The…

This study looked at how vimseltinib affects two proteins that help move drugs out of the body. Twenty healthy men took rosuvastatin with and without vimseltinib to see if the combination changed drug levels. The goal was to gather safety and interaction data, not to treat any di…

This study looked at how a drug called elenestinib changes the way the body processes midazolam (a sedative) and a common birth control pill. Twenty healthy adult women took these drugs with and without elenestinib, and had blood tests to measure drug levels. The goal was to gath…

This study tested how well different versions of the drug TEV-56286 are absorbed by the body in 47 healthy adults. Participants took single doses of the drug in different forms, and researchers measured drug levels in the blood. The goal was to compare the new formulations to the…

This study measured how different ways of carrying a school backpack change the pressure on the soles of the feet in 92 healthy adolescents. Participants walked with no backpack, on both shoulders, and on each shoulder alone. The main finding was that carrying a backpack on one s…

This study looked at how much of the drug rozanolixizumab passes into breast milk after a single dose. Fifteen healthy, lactating women who had already decided to stop breastfeeding took part. Researchers collected breast milk samples over 7 days to measure drug levels and estima…

This study looked at how healthy adults' immune systems respond to the rabies vaccine. Thirty participants received the vaccine with or without additional antibodies (RIG) at different times. The goal was to measure antibody levels over a year to better understand immune response…

This study looked at how healthy adults tolerate injections of immunoglobulin G (a type of antibody) given under the skin. Researchers tested different injection conditions to see which caused the least pain and side effects. The goal was to gather safety information, not to trea…

This study looked at how a nature-based therapy program affects stress and quality of life in 100 healthy adults living in Barcelona. Participants took part in activities in a coastal urban natural setting. The goal was to see if this type of therapy can help build resilience to …

This study looked at how different amounts of water and delays before breakfast affect levels of a new semaglutide tablet in the blood. 121 healthy men took the tablet daily for 10 days. The goal was to find the best way to take the medicine for future use.

This study tested a commercially available oral NAD+ supplement in 60 healthy adults aged 45-75. Over 5 days, researchers measured whether the supplement raised NAD+ levels in the blood and inside cells, and whether it changed other biological markers related to health. The study…

This study tested a new propellant (HFA-152a) in salbutamol inhalers to see if it delivers the drug similarly to the current propellant (HFA-134a). Sixty healthy adults aged 18-55 received single doses of 200 or 800 micrograms in a crossover design. The goal was to compare how mu…

This study tested a new formulation of the medicine semaglutide in healthy adults. The goal was to measure how much of the drug gets into the blood with the new tablet compared to the current one. About 264 participants took different doses daily for up to 21 weeks. The study is …

This study looked at how a new tablet form of the drug minzasolmin is absorbed in 18 healthy adults, and whether eating food changes that. Participants took the drug and had blood samples taken to measure drug levels. The goal was to gather information, not to treat any disease.

This early-stage study tested the safety and how the body processes a single dose of donzakimig in 32 healthy Chinese and Japanese adults. Participants received either the drug or a placebo, and researchers monitored side effects and drug levels in the blood. The goal was not to …

This early-stage study tested the safety of a new drug, AZD8965, in 147 healthy adults, including Japanese and Chinese participants. Researchers gave single or multiple doses to see how the body processes the drug and whether food affects it. The goal was to gather safety informa…

This study tested 50 healthy adolescents aged 15-16 to find normal handgrip strength values using a digital device. Participants squeezed a handheld dynamometer as hard as they could, and some repeated the test after 1-2 weeks to check consistency. The goal is to create reference…

This study looked at whether taking a short, daily 5-minute bath in 45°C (113°F) water for two weeks could help healthy adults adapt to heat. 26 people took part. Researchers measured body temperature, heart rate, and other signs to see if this quick method works as well as longe…

This early-stage study tested an experimental drug called AZD2389 in 120 healthy volunteers to see if it is safe and how the body handles it. Participants received either the drug or a placebo, and researchers monitored for side effects and measured drug levels in blood and urine…

This study looked at whether a new drug called clofutriben affects how the body processes two other drugs, midazolam and prednisolone. Sixteen healthy adults took clofutriben daily for 16 days along with single doses of the other drugs. The goal was to measure drug levels in the …

This study looked at how immersive virtual reality affects memory, pain, and anxiety in healthy adults. 16 participants completed word recall tests while using VR. The goal was to see if VR could distract people enough to change their memory of events.

This study tested a single dose of the drug AZD4144 in 41 adults to see how their bodies processed it. Some had severe kidney disease or end-stage kidney disease, while others were healthy. The goal was to understand safety and drug levels, not to treat the disease.

This study explored how the number of calories in a meal and the time of day you eat affect your body's metabolism and blood vessel health. Researchers measured how 20 healthy adults burned energy and how their arteries responded after eating different meals. The goal was to unde…

This study looked at how a high-fat, high-calorie meal changes the amount of two drugs (zibotentan and dapagliflozin) in the blood of 26 healthy adults. Participants took the drugs once with food and once without, and researchers measured drug levels and side effects. The goal wa…

This study looked at whether a 4-week program of elastic band exercises could improve hip strength and agility in 21 healthy young male basketball players aged 15-18. Half the players did the band exercises plus their regular training, while the other half only did their regular …

This early-stage study tested a new drug called AZD6793 in 39 healthy Japanese and Chinese adults to see if it is safe and how the body processes it. Participants received either the drug or a placebo as a liquid by mouth. The goal was to check for side effects and measure drug l…

This early-stage study tested the safety of a new drug called ATX101 in 24 healthy adults. Participants received a single dose through a vein, and researchers monitored for side effects and how the drug moved through the body. The goal was not to treat any disease, but to gather …

This study checked if a new insulin aspart (NKF-INS(A)) is similar to two already-approved insulins (US-NovoLog and EU-NovoRapid). It involved 54 healthy adult men who received a single dose of each insulin in a random order. Researchers used a special technique to measure how th…

This study looked at whether stretching or massaging the neck can also improve flexibility in the hip. Thirty healthy adults received both a neck stretch and a neck massage on separate days. Researchers measured neck and hip movement before and after each treatment to see if ther…

This study looked at how a single dose of a new insulin, THDB0206, is absorbed and works when injected into different body sites. It involved 27 healthy Chinese adults. The goal was to understand if injection location affects how the insulin behaves in the body.

This study checked if certain skin products are safe by applying them to the skin of 26 healthy adults for 24 hours. Researchers looked for reactions like redness, dryness, or swelling. The goal was simply to gather safety information, not to treat or cure any disease.

This study tested a new drug called S-740792 in 99 healthy adults to see if it is safe and how the body handles it. The study also looked at how food and another drug (midazolam) affect S-740792. This is an early-stage trial with no direct treatment benefit for participants.

This study looked at how healthy adult men break down and get rid of a single dose of the experimental drug Quemliclustat. Eight participants received a radioactive-labeled version of the drug so researchers could measure it in blood, urine, and stool. The goal was to understand …

This study looked at how the body absorbs ZN-A-1041 when given as a tablet compared to a capsule. It involved 18 healthy adults who took the drug in different forms. The goal was to see which form works best and how food or stomach acid medicine might affect absorption. No partic…

This study tested two different ways of stimulating the median nerve in the wrist to see which one improves handgrip strength more. 86 healthy adults aged 18-40 received a single 10-minute session of ultrasound-guided nerve stimulation. The goal was to learn which stimulation pat…

This study tested whether a short, personalized virtual reality (VR) experience could help general practitioners feel better and become more flexible in handling stress. Twenty-one healthy doctors used a VR headset for 10 minutes, then reflected on their values and planned action…

This study looked at how a drug called vimseltinib changes the way the body handles metformin, a common diabetes medicine. Twenty-two healthy men took part to measure drug levels and check for side effects. The goal was to gather safety and interaction information, not to treat a…

This study looked at whether getting real-time feedback from a virtual trainer avatar during virtual reality exercise makes people feel better and move more accurately. 28 healthy adults did three short VR workout sessions with different types of feedback (none, verbal only, or v…

This study looked at how eating a high-fat or low-fat meal changes the way the body absorbs a new drug called ammoxetine. Eighteen healthy adults took the drug once under different meal conditions. The goal was to understand if food affects drug levels in the blood, which helps d…

This early-stage study tested the safety and tolerability of a new drug called LY4060874 in 121 healthy adults. Participants were monitored for side effects and how the drug moved through their bodies. The study did not aim to treat any disease, but to gather important safety inf…

This early-stage study tested the safety of a new drug called CDX-622 in 85 healthy adults aged 18 to 55. Participants received either the drug or a placebo, and researchers monitored for side effects, drug levels in the blood, and changes in certain body chemicals. The goal was …

This study looked at how a new drug called AZD5004 interacts with two other medications in healthy volunteers. In one part, participants took AZD5004 with itraconazole (an antifungal) to see if it changed drug levels. In another part, healthy women took AZD5004 with birth control…

This was an early-stage study to check the safety and see how the body processes a new drug called UCB9741. It involved 40 healthy adult volunteers from Caucasian and Japanese backgrounds who received a single injection. The main goal was to monitor for any side effects and measu…