New semaglutide pill study: does water amount matter?

NCT ID NCT05996874

Completed Knowledge-focused Sponsor: Novo Nordisk A/S Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested a new tablet version of semaglutide (the drug in Ozempic and Rybelsus) in 121 healthy men. Researchers wanted to see how different amounts of water (50 mL vs 120 mL) and different delays before breakfast (30, 60, or 120 minutes) affect drug levels in the blood. Participants took one tablet daily for 10 days. The goal is to find the best way to take the pill for consistent absorption.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

semaglutide

What this could lead to

If successful, this could help optimize how to take oral semaglutide for better absorption and effectiveness.

What could go wrong

This is an early-phase study in healthy people, not patients. Results may not apply to those with diabetes or other conditions.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEALTHY PARTICIPANTS

Contacts and locations

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Locations

Profil Institut für Stoffwechselforschung GmbH

Neuss, 41460, Germany