New obesity drug AZD4144 enters human testing
NCT ID NCT06942923
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This early-stage study tested a new drug called AZD4144 in 28 adults with obesity to see if it is safe and how it affects inflammation markers in the blood. Participants took either the drug or a placebo daily for a short time. The goal was to check for side effects and measure changes in certain inflammatory substances, like interleukin-6. This is a first step in humans, so results will show whether the drug is safe enough for larger studies.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
AZD4144
What this could lead to
If it works, this could point toward a treatment for obesity that also reduces inflammation.
What could go wrong
This is a very early Phase 1 trial with only 28 participants, so it is primarily checking safety, not effectiveness. The drug may not work or could have side effects.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Research Site
Berlin, 14050, Germany