Inhaled alprazolam race: can it beat IV sedatives?
NCT ID NCT07020988
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This completed phase 1 study tested how quickly an inhaled form of alprazolam (Staccato) affects brain activity compared to intravenous midazolam and nasal diazepam. Fifty-five healthy adults received single doses of each drug in a crossover design. Researchers used EEG brain wave monitoring to measure the time to onset of action. The goal is to see if this inhaled approach could provide a fast, needle-free option for conditions like seizures.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Staccato alprazolam (inhaled), midazolam (intravenous), diazepam (nasal)
- What this could lead to
- If successful, this study could show that inhaled alprazolam works as fast as IV sedatives, potentially offering a needle-free option for rapid seizure control.
- What could go wrong
- This is a very early phase 1 study in only 55 healthy people, not patients. It measures brain wave changes, not real-world seizure stopping. The results may not translate to actual treatment benefits.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for HEALTHY PARTICIPANTS are added.
By submitting, you agree to our Terms of use
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Up0127 1001
Glendale, California, 91206, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a common antifungal change how an experimental drug acts?
- Can a new injection help tackle obesity? a safety trial begins
- Will a new pill formula absorb the same? a trial puts it to the test
- Can a new drug tame Alzheimer's? early trial aims to find out
- Could sitting too much alter your nervous system?
- Could a cancer drug alter Metformin's effects? a trial investigates