HEALTHY PARTICIPANTS

This early-stage study tests a new vaccine called VXB-251 in 240 healthy adults aged 60-83. The vaccine is designed to protect against three viruses that can cause serious lung infections: RSV, hMPV, and PIV3. Researchers will check if the vaccine is safe and how well it triggers…

This early-stage study tests a new drug called AZD0780 in 40 healthy adults with high LDL (bad) cholesterol. Participants receive either the drug or a placebo to see if it safely lowers cholesterol levels. The goal is to gather initial safety and effectiveness data before moving …

This study looks at whether two herbal supplements, CL19183 and CL24212, can help overweight adults lose weight and improve their health. About 150 healthy but overweight people (BMI 25-30) aged 25-55 will take the supplements or a placebo, plus walk 30 minutes daily and follow a…

This early-stage trial is testing whether a new long-acting antiviral medicine called CD388 can be safely given at the same time as the high-dose flu vaccine. About 100 healthy adults aged 18 to 49 will receive either the vaccine plus CD388 or the vaccine plus a placebo. Research…

This study tests the safety of giving repeated annual doses of an experimental drug called CD388 to healthy adults. About 400 people who already tolerated one dose without serious side effects will receive two more doses over two years. Researchers will monitor for side effects a…

This study tests whether a virtual reality (VR) game can teach primary schoolchildren aged 6-12 better hygiene habits to prevent the spread of COVID-19 and other respiratory viruses. Over 2,000 children will either play the VR game for two weeks or receive standard education. Res…

This study tested whether taking 400 mg of magnesium citrate daily for 90 days could improve sleep quality and cognitive function in healthy Saudi adults who reported poor sleep. Researchers compared 41 participants who took the supplement to a control group that took nothing. Th…

This study compares a new surgical approach (gingivalstat) to the standard crown-lengthening surgery for people with a gummy smile due to altered passive eruption. The goal is to see which method keeps the gum line more stable over 6 months. About 22 healthy adults will participa…

This early-stage study is testing a single injection of a new drug called AG-236 in 24 healthy adults aged 18 to 55. The main goal is to see if it is safe and how the body processes it. No treatment for any disease is being tested here.

This early-stage trial in 48 healthy volunteers checks whether a new drug called elecoglipron changes how the body processes two common statins (atorvastatin and rosuvastatin). Participants take the statin alone and later with elecoglipron, and researchers measure drug levels in …

This early-phase trial is testing the safety and tolerability of a new drug called AZD0292 in 18 healthy Japanese adults. Participants receive a single dose of the drug or a placebo by IV infusion. The study aims to understand how the drug moves through the body and whether it ca…

This early-stage study compares two forms of the cholesterol-lowering drug evolocumab in 400 healthy adults aged 18 to 60. Participants receive a single injection of one version, and researchers measure how much drug gets into the blood and how long it stays. The goal is to see i…

This study checks if two different devices for injecting trastuzumab under the skin work the same way in the body. It involves 312 healthy men who will get a single dose. The goal is to see if the drug levels are similar, not to treat any disease.

This early-stage study is testing a new drug, INCA033989, in 72 healthy adults aged 18 to 55. The goal is to see how the drug moves through the body and whether it is safe when given as a shot under the skin or through an IV. No disease is being treated — this is a first step to …

This early-stage study tests a drug called andexanet alfa, which is designed to reverse the effects of common blood thinners like rivaroxaban and apixaban. Researchers will give these blood thinners to 179 healthy volunteers, then give andexanet to see how well it works and how i…

This early-stage study tests whether IBI3033 is safe and how the body processes it. Eight healthy adults in China will receive either the drug or a placebo. The goal is to check for side effects and measure drug levels in the blood, not to treat any disease.

This early-stage trial is testing the safety and how the body handles a single dose of IBI3033 in 32 healthy Chinese adults. Participants receive either the drug or a placebo and are monitored for side effects and drug levels over 12 weeks. Since it involves healthy people, there…

This early-stage study in 32 healthy adults looks at how a new drug called AZD5004 changes the way the body processes two diabetes medications, mitiglinide and pioglitazone. The goal is to understand potential drug interactions, not to treat any disease. Participants take the dru…

This study looks at whether using intermittent pneumatic compression boots after exercise helps collegiate athletes recover faster. Researchers will measure blood lactate levels, ankle range of motion, and vertical jump performance in 38 healthy NCAA athletes. The goal is to see …

This study looks at whether using a heating pad or a foam roller before exercise can help athletes produce more force in their legs during a squat jump. Researchers will measure force production in 38 college athletes aged 18-23. The goal is to see if these simple tools can impro…

This study looks at whether vitamin D levels are linked to certain immune markers in people with active tuberculosis (TB), with or without a chronic fungal lung infection called aspergillosis. Researchers will compare blood samples from 300 adults—including healthy volunteers—to …

This study looks at whether a special education program about patient safety can shift the views of nursing leaders and educators in a Saudi medical city. About 102 head nurses, assistant head nurses, and educators will take a survey before the training, then again 3 and 6 months…

This study looks at how well three different tablet versions of the drug LY4100511 are absorbed by the body in 48 healthy adults. It also checks if taking a common stomach acid medicine (a proton pump inhibitor) changes absorption. The goal is to find the best tablet form for fut…

This pilot study looks at whether listening to self-selected Levantine music can change how sensitive healthy young adults are to pressure pain, compared to silence. Twelve Lebanese university students will have their pain threshold and mood measured before and after each conditi…

This study tests a new drug called QL2106 against an approved drug, Tremfye® (guselkumab), in 190 healthy adults aged 18-45. The goal is to compare how the body processes each drug, their safety, and immune response after a single dose. Participants receive one injection and are …

This study tests whether focused ultrasound to the brain can change how the anesthetic propofol works. Ten healthy adults will receive both real and fake ultrasound while under sedation. Researchers will measure brain signals and response times to see if ultrasound alters anesthe…

This study looks at whether a special breathing warm-up can temporarily strengthen the muscles you use to breathe, helping athletes during exercise. About 28 trained athletes aged 14-30 will try three conditions: a breathing warm-up, a fake warm-up, and no warm-up. Researchers wi…

This study aims to figure out the best schedule for follow-up visits for people who wear contact lenses. Researchers will track 300 healthy adults aged 18 to 40 who are new or experienced lens wearers. The goal is to see if fewer visits can still keep eyes safe and comfortable.

This early-stage trial is testing the safety of a new experimental drug called mRNA-0184 in 52 healthy adults. Participants receive one or more injections of the drug, and researchers monitor for side effects and how the drug moves through the body. Since this is a Phase 1 study,…

This study tests whether doing very short, intense bike sprints—just 10 to 20 seconds, twice a week—can improve cardiorespiratory fitness in inactive adults. Sixty healthy, overweight but otherwise healthy participants will complete 18 sessions over 9 weeks, and their results wil…

This study looks at brain activity and heart patterns in people who have had a stroke and compares them to healthy adults. Researchers use special head sensors and heart monitors to measure differences. The goal is to better understand how stroke changes the brain and heart. No t…

This study tests whether a new biosimilar medicine (CT-P52) works similarly to the approved drug Taltz in the body. It involves 218 healthy adults aged 19 to 55 who receive a single dose of either the biosimilar or Taltz. The main goal is to compare how the drug is absorbed and i…

This Pfizer study aimed to check if new combination tablets of nirmatrelvir/ritonavir (the drug in Paxlovid) work the same as the current marketed version. About 28 healthy adults were to receive single doses of different tablet forms under fasting conditions. However, the study …

This study tests whether four one-hour supervision sessions with a psycho-oncologist can help oncology and hematology clinicians handle difficult patient interactions. The 62 participants are doctors or nurses who will discuss challenging cases and reflect on their feelings. The …

This early-stage study tests a new drug called STAR-0310 in 40 healthy adults to see if it is safe and how the body processes it. Participants receive either the drug or a placebo, and researchers monitor for side effects. This study does not aim to treat any disease; it is a fir…

This study involves 400 healthy adults aged 60-85 to test new computerized measures of thinking and daily function. Participants are randomly assigned to take either the new tests or standard tests over one year. The goal is to see if the new tests are better at detecting changes…

This study compares the effects of Swedish massage versus light touch on brain activity, heart rate, blood pressure, and mood in 30 healthy adults. Participants are randomly assigned to one session of either massage or light touch, and undergo brain scans before and after. The go…

This study tests whether a simple pillow can be as effective as a standard manikin for teaching CPR to healthy adults. 128 participants will be trained using either a pillow or a manikin, and researchers will measure compression depth, number of compressions, and hand position. I…